“…While cannabis is the most widely used illicit substance globally [10], decades of study have demonstrated that the majority of mainly infrequent users suffer negligible health effects [11,12]. Indeed, patterns of moderate, controlled use predominate for the majority of adult consumers, such that daily cannabis users are often hard to distinguish, in terms of health, social, and economic markers, from individuals who have never used the drug [13,14,15]. Nevertheless, researchers have identified a range of potential harms, particularly in relation to long-term heavy use, while the associated risks of exposure in youth dictate caution and the importance of prevention [16,17,18,19,20,21,22].…”