CaP cement is equivalent to iliac bone graft in filling of large metaphyseal defects: 2 year prospective randomised study on distal radius osteotomies

Winge, Mona I.; Røkkum, Magne

doi:10.1016/j.injury.2017.11.027

Cited by 10 publications

(14 citation statements)

References 37 publications

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“…Control Beads MPC-Vanc Beads 0 cm 2 2.89 cm 2 0 cm 2 3.85 cm 2 0 cm 2 3.46 cm 2 0 cm 2 4.09 cm 2 0 cm 2 3.52 cm 2 0 cm 2 3.27 cm 2 *MPC-vanc beads significantly increased over control beads for both bacterial strains. interpreting the data.…”

Section: S Aurous Culture Platesmentioning

confidence: 95%

Elution properties of a resorbable magnesium phosphate cement

Roller

Stoker

Cook

2020

Journal of Clinical Orthopaedics and Trauma

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Objective: This study tests the elution capabilities of a magnesium phosphate cement (MPC). Study objectives were to quantify the passive release of magnesium ions from MPC and to assess the effects of antibiotic-loaded MPC on bacterial growth and osteoblast viability. Methods: MPC constructs were created and incubated in fetal bovine serum (FBS). At 2, 4, and 17 weeks, a sample was collected for magnesium ion concentration analysis. Control and vancomycin-loaded (vanc) MPC beads were also created. Zone of inhibition was measured after incubating beads on Staphylococcus aureus agar plates for 24 h. Osteoblasts were seeded onto control and vanc beads and cultured for 9 days. Metabolic activity was measured via a resazurin assay. ANOVA with Tukey HSD post-hoc tests and t-tests were performed. Results: Magnesium ions were eluted at 2 and 4-week time points without significant difference, but demonstrated a significant spike at the 17-week time point. Zones of inhibition for the bacterial species was observed for Vanc-MPC beads, but not control beads. No cytotoxic effects on osteoblasts were noted. Conclusion: MPC has potential to improve bone regeneration based on its ability to passively elute magnesium. Additionally, antibiotic-loaded MPC inhibits bacterial growth while avoiding osteoblast cytotoxicity.

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Section: S Aurous Culture Platesmentioning

confidence: 95%

Elution properties of a resorbable magnesium phosphate cement

Roller

Stoker

Cook

2020

Journal of Clinical Orthopaedics and Trauma

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“…An autograft from the iliac crest is often used, but this may lead to pain and other complications at the donor site [11]. To reduce complications of this kind, the use of a synthetic bone substitute is an option [12,13], while leaving the void open is another option [14].…”

Section: Introductionmentioning

confidence: 99%

Functional outcome after corrective osteotomy for malunion of the distal radius: a randomised, controlled, double-blind trial

Andreasson

Kjellby-Wendt

Olsén

et al. 2020

International Orthopaedics (SICOT)

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Purpose The purpose of this randomised, controlled, double-blind trial was to evaluate functional outcome during the first year after corrective osteotomy for malunited distal radius fractures, with or without filling the osteotomy void. Method Patients were randomised to receive a HydroSet bone substitute or no graft. Cortical contact was maintained and stabilisation of the osteotomy was carried out with a DiPhos R-or RM Plate. To evaluate subjective functional outcome, the Patient-Rated Wrist Evaluation (PRWE), the Quick Disabilities of the Arm, Shoulder and Hand Questionnaire (Q-DASH), the Canadian Occupational Performance Measure (COPM) and the RAND-36 were used. Moreover, range of motion and grip strength were measured by blinded evaluators. Evaluations were made pre-operatively and three, six and 12 months postoperatively. Results There were no significant differences between the groups at any time point post-operatively with respect to any of the PROMs that were used or range of motion or grip strength (p > 0.05). In both groups, there was a significant improvement at the 12-month follow-up compared with pre-operatively for the PRWE, the Q-DASH and the COPM satisfaction scores. The RAND-36 revealed no significant differences except for two domains, in which there was an improvement in the treatment group (p < 0.05). For grip strength and for range of motion in all movement directions, except dorsal extension, there was a significant improvement in both groups (p < 0.05). Conclusion There is no significant difference in functional outcome during the first year after corrective open-wedge distal radius osteotomy, where cortical contact is maintained, regardless of whether or not bone substitute to fill the void is used.

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“… [5] In some circumstances, therapeutic methods should be directed at symptoms rather than results of imaging examination. [6] Some studies reported that the bone loss caused by osteotomy operation must be padded by cartilage, [7] bone, [8] or bone substitute. [1] Here, we report a rare clinical case of an adolescent boy with malunion of distal radius fracture, using autogenous bone graft transfer from the ilium to the distal radius after osteotomy to recover the radiocarpal joint.…”

Section: Introductionmentioning

confidence: 99%

Distal radius fracture malunion in an adolescent patient treated with osteotomy and autologous iliac bone grafting

Liu

et al. 2020

Medicine

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Rationale: Adolescent wrist trauma can cause epiphyseal dysplasia and even distal radius deformity malunion. At present, there is no uniform treatment standard for the malunion of the distal radius of adolescents. Osteotomy and autologous bone grafting are currently one of the effective ways to treat the disease. We treated an adolescent patient with distal radius deformity malunion, and used this surgical method to treat the patient and achieved satisfactory results. Patient concerns: A 16-year-old boy suffered from a serious distal radius deformity after trauma of the left wrist 8 years ago. Diagnoses: Physical examination, X-rays examination, high-resolution computed tomography scan, and 3-dimensional reconstruction images of the affected limb helped us diagnose the distal radius fracture malunion. Interventions: The fracture malunion was treated by osteotomy and autologous iliac bone grafting. Outcomes: At the 2-year follow-up, wrist flexion returned to 68°, wrist dorsiflexion to 55°, radial deviation to 14°, ulnar deviation to 12°, forearm pronation to 75°, supination to 67°. Grip strength increased to 35.1 kg after 2 years of operation, recovered to 87% of the uninjured side. Quick DASH score at 2-year follow-up was 9. No complication, such as nonunion or infection, was observed. Lessons: This rare case provides valuable insights for hand surgeons. High-resolution computed tomography scan and 3-dimensional reconstruction can help us effectively diagnose wrist diseases. Small lesions on the articular surface of the distal radius will change the position and function of the wrist joint, and cause traumatic arthritis of the wrist joint. Therefore, it is very important to reconstruct the normal structure of the distal radius articular surface. Osteotomy and autologous iliac bone grafting are effective treatments for serious distal radius fracture malunion in the adolescent patient. During the operation, care should be taken to protect the osteoepiphysis to avoid bone dysplasia.

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CaP cement is equivalent to iliac bone graft in filling of large metaphyseal defects: 2 year prospective randomised study on distal radius osteotomies

Cited by 10 publications

References 37 publications

Elution properties of a resorbable magnesium phosphate cement

Elution properties of a resorbable magnesium phosphate cement

Functional outcome after corrective osteotomy for malunion of the distal radius: a randomised, controlled, double-blind trial

Distal radius fracture malunion in an adolescent patient treated with osteotomy and autologous iliac bone grafting

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