Capabilities of 99mTc-pyrphotech single-photon emission computed tomography in combination with myocardial perfusion scintigraphy in the evaluation of inflammatory changes in the heart of patients with persistent atrial fibrillation

Сазонова, С. И.; Лишманов, Ю. Б.; Баталов, Р. И.; Popov, Sergey; Ильюшенкова, Ю. Н.; Роговская, Ю. В.; Idrisov, M. Z.

doi:10.17116/terarkh2014861210-14

Cited by 7 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It allowed getting rid of the intracardiac and intravascular pools and decreasing the number of false-positive results as much as possible. We have used this approach since 2013 [9,10] and it was approved using the large number of patients and proved to be valuable.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac SPECT/CT. Cardiac SPECT study was performed 3 and 24 hours after intravenous infusion of 370 MBq of 99m Tc-Pyrophosphate [9,10]. Scintigraphic images were acquired by hybrid SPECT/CT scanner GE Discovery NM/CT 570c (GE Healthcare, Milwaukee, WI, USA) equipped with solid state cadmium-zinc-telluride detectors.…”

Section: Data Acquisitionmentioning

confidence: 99%

“…Over the last years, the methods of integrated radionuclide diagnostics of myocarditis have been implemented in clinical practice. ese methods are based on the fusion of scintigraphic images obtained with administration of radiopharmaceuticals for inflammation diagnostic ( 99m Tc-HMPAO-autoleukocytes, 99m Tc-Pyrophosphate) and the myocardial perfusion images [9]. Indeed, the efficacy of single-photon emission computed tomography (SPECT) with 99m Tc-Pyrophosphate has been demonstrated for evaluation of latent inflammatory changes in the heart of patients with persistent form of AF [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…ese methods are based on the fusion of scintigraphic images obtained with administration of radiopharmaceuticals for inflammation diagnostic ( 99m Tc-HMPAO-autoleukocytes, 99m Tc-Pyrophosphate) and the myocardial perfusion images [9]. Indeed, the efficacy of single-photon emission computed tomography (SPECT) with 99m Tc-Pyrophosphate has been demonstrated for evaluation of latent inflammatory changes in the heart of patients with persistent form of AF [9,10]. At the same time, these radionuclide imaging approaches are multistage, require administration of two radiopharmaceuticals, and do not allow for accurate anatomic identification of the foci of indicator accumulation beyond the left ventricular (LV) contours.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Ilyushenkova

Сазонова

Zavadovsky

et al. 2020

Cardiology Research and Practice

View full text Add to dashboard Cite

Objectives. This work aimed to study the efficacy of hybrid 99mTc-Pyrophosphate SPECT/CT for diagnosis of latent inflammatory processes in the myocardium of patients with atrial fibrillation (AF). Methods. The study comprised 34 patients aged 44 ± 9 years with AF of unknown etiology referred for radiofrequency ablation. The data were acquired using hybrid 99mTc-Pyrophosphate SPECT/CT. To evaluate and interpret the results of hybrid study and to determine localization of radiopharmaceutical accumulation, scintigraphic and CT images were fused. SPECT/CT results were compared with data of endomyocardial biopsy. Results. Sensitivity, specificity, and accuracy of 99mTc-Pyrophosphate SPECT/CT in diagnosing myocarditis were 91%, 100%, and 94%, respectively. Proposed diagnostic criteria for myocarditis comprised intensity of the radiopharmaceutical accumulation in the myocardium and the ratios of focus/lung, focus/vertebral column, and focus/LV pool. Minimum cutoff values for the histologically verified myocarditis were >1.47 for focus/lung index, >0.11 for focus/vertebral column ratio, and >1.26 for focus/lung index. Conclusions. SPECT/CT-based quantitative assessment of 99mTc-Pyrophosphate accumulation in the myocardium is a highly informative noninvasive method for diagnosis of inflammatory process in the heart in patients with AF of undefined etiology.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Data Acquisitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Ilyushenkova

Сазонова

Zavadovsky

et al. 2020

Cardiology Research and Practice

View full text Add to dashboard Cite

show abstract

“…We have proposed methods for scintigraphic diagnosis of inflammation in the heart using the 99m Tc-pyrophosphate radiopharmaceutical (RP) with a high diagnostic efficiancy [ 17 – 22 ]. In its original mode, however, these techniques cannot be used to visualize inflammation in the TA wall, since the radioactivity of the blood pooled in cavities of large vessels “overlaps” the local RP radioactivity in adjacent tissues [ 17 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Ilyushenkova¹,

Панфилов²,

Саушкин³

et al. 2021

Sovrem Tehnol Med

View full text Add to dashboard Cite

The aim of this study was to develop and test a technique for scintigraphic examination of the thoracic aorta, which allows for visualizing foci of inflammation.Materials and Methods. The study included 15 patients (median age -61 [47; 73] years) with aortic dilatation more than 45 mm and thoracic aortic aneurysm who were candidates for surgical treatment. All patients underwent a chest scintigraphy with 99m Tc-pyrophosphate 48 h before surgery to identify foci of inflammation in the aortic wall. The new technique included intravenous administration of 370 MBq of a radiopharmaceutical (RP), registration of scintigrams at 3 and 6 h after injection of RP in a tomographic mode combined with X-ray computed tomography. After the image reconstruction, subtraction of the later scintigrams from the early ones was performed, followed by analysis of the final images. The results of scintigraphy were compared with the histological data obtained from intraoperative samples of resected aorta.Results. According to the results of this novel scintigraphic technique, artifacts from the radioactivity of the vascular blood pool were eliminated and pathological RP uptake was identified in 5 (33.3±1.5%) out of 15 examined patients. The "focus/vessel lumen" ratio averaged at 1. 47 [1.30; 1.48]. Histological examination of resected aorta samples confirmed the presence of chronic inflammation in 4 (26.7±1.3%) out of 15 patients. Parameters of diagnostic efficiency were: sensitivity -100%, specificity -91%, diagnostic accuracy -93%.Conclusion. The method of scintigraphic diagnostics of inflammatory processes in the aorta using 99m Tc-pyrophosphate, supplemented by subtraction of the late from the early images, makes it possible to eliminate artifacts from the radioactivity of the aortic blood pool and to reveal the pathological RP accumulation indicating the areas of inflammation in the aortic wall.

show abstract

Assessment of radiological techniques application possibility for non-invasive diagnostics of latent inflammatory processes in myocardium in patients with atrial fibrillation

et al. 2016

View full text Add to dashboard Cite

show abstract

Capabilities of 99mTc-pyrphotech single-photon emission computed tomography in combination with myocardial perfusion scintigraphy in the evaluation of inflammatory changes in the heart of patients with persistent atrial fibrillation

Cited by 7 publications

References 12 publications

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Assessment of radiological techniques application possibility for non-invasive diagnostics of latent inflammatory processes in myocardium in patients with atrial fibrillation

Contact Info

Product

Resources

About

Capabilities of 99mTc-pyrphotech single-photon emission computed tomography in combination with myocardial perfusion scintigraphy in the evaluation of inflammatory changes in the heart of patients with persistent atrial fibrillation

Cited by 7 publications

References 12 publications

Diagnostic Efficacy of Cardiac Scintigraphy with 99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Diagnostic Efficacy of Cardiac Scintigraphy with 99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Assessment of radiological techniques application possibility for non-invasive diagnostics of latent inflammatory processes in myocardium in patients with atrial fibrillation

Contact Info

Product

Resources

About

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation