Capabilities of the Monte Carlo Simulation Codes for Modeling of a Small Animal SPECT Camera

Sadremomtaz, Alireza; Telikani, Zeinab

doi:10.1007/s13139-018-0530-0

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…While SPECT systems based on multi-pinhole collimators have shown high resolution at a good sensitivity in the clinical and preclinical applications [22][23][24][25][26][27][28][29][30][31][32][33], the imperfect detector usage is a challenging problem for circular projections of the holes over the detector surface [34]. To this end, the lofthole collimator, as a new version of pinhole, was utilized for breast SPECT imaging.…”

Section: Introductionmentioning

confidence: 99%

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Saed¹,

Sadremomtaz²,

Mahani³

2022

J. Inst.

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Background: the need for simultaneous high-sensitivity and high-resolution breast SPECT imaging mandates to design and optimize dedicated scanners. Therefore, this work aims to design and optimize a novel breast-dedicated SPECT system with multi-lofthole collimator. Materials and Methods: in this research, a novel breast-dedicated scanner is designed and then optimized. The scanner is equipped with a single full-ring multi-lofthole collimation long with modular NaI(Tl) detectors. The step-and-shoot data acquisition was considered with two steps. Then, an analytic optimization was conducted to balance the existing sensitivity-resolution tradeoff. To do so, several scanner geometries were investigated. The optimal configuration maximized the system sensitivity at a given system resolution. Furthermore, the scanner was also modeled within the GATE simulator. Then, detector energy resolution, septal penetration and scattering, and system sensitivity were calculated. Analytic findings were also compared with the simulated ones. Results: the results showed that high sensitivity of about 2 cps/kBq can be obtained for a diameter of lofthole 3.05 mm with a 75° opening angle. Results of GATE simulations showed clinically acceptable performance of the system offering 9% energy resolution for a point source. The septal penetration and scattering were approximately 0.5% and 0.2%, respectively, for cylindrical water phantom and tungsten as collimator material. Conclusion: the designed SPECT scanner provides promising results in terms of sensitivity and spatial resolution and therefore outperforms the traditional multi-pinhole collimation by a much higher sensitivity at a given system resolution.

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Section: Introductionmentioning

confidence: 99%

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Saed¹,

Sadremomtaz²,

Mahani³

2022

J. Inst.

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“…A preliminary simulation study is essential to work prior to the development of a real MSCC. In many biomedical applications, the simulation becomes a useful tool to validate the systematic performances and to compare with the real experimental results [7][8][9]. Through the simulation study, we could investigate the physical factors affecting the system performance and optimize the geometrical parameters, such as the distance between detectors, the size of the detector, as well as the image reconstruction parameters.…”

Section: Introductionmentioning

confidence: 99%

Analytic simulator and image generator of multiple-scattering Compton camera for prompt gamma ray imaging

Kim

2018

Biomed. Eng. Lett.

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For prompt gamma ray imaging for biomedical applications and environmental radiation monitoring, we propose herein a multiple-scattering Compton camera (MSCC). MSCC consists of three or more semiconductor layers with good energy resolution, and has potential for simultaneous detection and differentiation of multiple radio-isotopes based on the measured energies, as well as three-dimensional (3D) imaging of the radio-isotope distribution. In this study, we developed an analytic simulator and a 3D image generator for a MSCC, including the physical models of the radiation source emission and detection processes that can be utilized for geometry and performance prediction prior to the construction of a real system. The analytic simulator for a MSCC records coincidence detections of successive interactions in multiple detector layers. In the successive interaction processes, the emission direction of the incident gamma ray, the scattering angle, and the changed traveling path after the Compton scattering interaction in each detector, were determined by a conical surface uniform random number generator (RNG), and by a Klein-Nishina RNG. The 3D image generator has two functions: the recovery of the initial source energy spectrum and the 3D spatial distribution of the source. We evaluated the analytic simulator and image generator with two different energetic point radiation sources (Cs-137 and Co-60) and with an MSCC comprising three detector layers. The recovered initial energies of the incident radiations were well differentiated from the generated MSCC events. Correspondingly, we could obtain a multi-tracer image that combined the two differentiated images. The developed analytic simulator in this study emulated the randomness of the detection process of a multiplescattering Compton camera, including the inherent degradation factors of the detectors, such as the limited spatial and energy resolutions. The Doppler-broadening effect owing to the momentum distribution of electrons in Compton scattering was not considered in the detection process because most interested isotopes for biomedical and environmental applications have high energies that are less sensitive to Doppler broadening. The analytic simulator and image generator for MSCC can be utilized to determine the optimal geometrical parameters, such as the distances between detectors and detector size, thus affecting the imaging performance of the Compton camera prior to the development of a real system.

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Accurate Monte Carlo Modeling of Small-Animal Multi-Pinhole SPECT for Non-Standard Multi-Isotope Applications

Lukas

Kluge

Beindorff

et al. 2021

IEEE Trans. Med. Imaging

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Capabilities of the Monte Carlo Simulation Codes for Modeling of a Small Animal SPECT Camera

Cited by 4 publications

References 21 publications

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Design and optimization of a breast-dedicated SPECT scanner with multi-lofthole collimation

Analytic simulator and image generator of multiple-scattering Compton camera for prompt gamma ray imaging

Accurate Monte Carlo Modeling of Small-Animal Multi-Pinhole SPECT for Non-Standard Multi-Isotope Applications

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