Capability deprivation of people with Alzheimer's disease: An empirical analysis using a national survey

Tellez, Juan; Krishnakumar, Jaya; Bungener, Martine; Galès, Catherine Le

doi:10.1016/j.socscimed.2015.12.032

Cited by 17 publications

(19 citation statements)

References 46 publications

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“…Additionally, oxidative stress and inflammatory pathways are biochemical mechanisms intrinsic to AD pathology and affect mitochondrial function as well as contribute to the loss of synaptic connections and neuronal death . Considering the fact that AD represents a significant burden on the economy, on public health policy, and there is still no cure, efforts are being made worldwide to identify strategies that can delay its onset and progression . Modifiable environmental factors may contribute to cognitive health (thus increasing brain reserve), characterized by structural characteristics of the brain that provide resilience against brain aging and pathology .…”

Section: Introductionmentioning

confidence: 99%

Melatonin induces mechanisms of brain resilience against neurodegeneration

Corpas

Griñán-Ferré

Palomera-Ávalos

et al. 2018

Journal of Pineal Research

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Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions and protective capacity against age-related ailments. The increase in circulating levels of melatonin through dietary supplements intensifies its health benefits. Investigations in animal models have shown that melatonin protects against Alzheimer's disease (AD)-like pathology, although clinical studies have not been conclusive. We hypothesized that melatonin induces changes in the brain that prevent or attenuate AD by increasing resilience. Therefore, we treated healthy nontransgenic (NoTg) and AD transgenic (3xTg-AD) 6-month-old mice with a daily dose of 10 mg/kg of melatonin until 12 months of age. As expected, melatonin reversed cognitive impairment and dementia-associated behaviors of anxiety and apathy and reduced amyloid and tau burden in 3xTg-AD mice. Remarkably, melatonin induced cognitive enhancement and higher wellness level-related behavior in NoTg mice. At the mechanism level, NF-κB and proinflammatory cytokine expressions were decreased in both NoTg and 3xTg-AD mice. The SIRT1 pathway of longevity and neuroprotection was also activated in both mouse strains after melatonin dosing. Furthermore, we explored new mechanisms and pathways not previously associated with melatonin treatment such as the ubiquitin-proteasome proteolytic system and the recently proposed neuroprotective Gas6/TAM pathway. The upregulation of proteasome activity and the modulation of Gas6 and its receptors by melatonin were similarly displayed by both NoTg and 3xTg-AD mice. Therefore, these results confirm the potential of melatonin treatment against AD pathology, by way of opening new pathways in its mechanisms of action, and demonstrating that melatonin induces cognitive enhancement and brain resilience against neurodegenerative processes.

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Section: Introductionmentioning

confidence: 99%

Melatonin induces mechanisms of brain resilience against neurodegeneration

Corpas

Griñán-Ferré

Palomera-Ávalos

et al. 2018

Journal of Pineal Research

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“…All identified questionnaires are constructed for self-completion and use subjective measures to assess capabilities. [28,75], and 8 reported results of actual measurements of health-related capabilities [23,24,27,41,[44][45][46][47]. The remaining (n = 14) articles had a mixed focus: on development/measurement (n = 2) [25,26], development/psychometric properties (n = 9) [29, 30, 36-38, 43, 51, 53, 62], or comparison/psychometric properties (n = 3) [59,60,73].…”

Section: Resultsmentioning

confidence: 99%

Measuring capabilities in health and physical activity promotion: a systematic review

et al. 2021

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Background The capability approach by Amartya Sen and Martha Nussbaum has gained increasing attention in the field of public health. As it combines individual, social and structural factors and shifts the focus of attention from the actual behavior towards available options for health behaviors that people can actually choose from, it may help advance our understanding of complex health issues. Objectives The aim of this article is to identify and describe tools available to measure capabilities within the context of health, with a specific focus on capabilities for health-enhancing physical activity. Method We conducted a systematic literature review using 11 databases covering scientific journal articles published in English or German between the years 2000 and 2020 with a focus on capabilities for health or physical activity. Results We found a total of 51 articles meeting our inclusion criteria. Four articles measured capabilities using qualitative methods, one combined qualitative and quantitative methods, while the rest used quantitative methods. We identified a total 11 different capability questionnaires, all showing moderate to good validity/reliability. Only one questionnaire and one interview-based tool specifically dealt with capabilities for health enhancing physical activity. Conclusion Although we were able to identify measurement tools for capabilities in health, this review has shown that there is no generic tool available for the measurement across all population- and age-groups, and tools focusing on physical activity are scarce. However, our results can be used as guide for future projects that aim at measuring capabilities.

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“…These capabilities were developed into a long questionnaire, which was piloted on a separate sample and then refined (Kinghorn et al 2015). Tellez et al (2016) assess the wellbeing of older people with and without Alzheimer's disease from the point of view of their functionings and latent capabilities. They find that persons with Alzheimer's disease have lower levels, and a smaller set, of capabilities, when compared to persons without the disease, even when the latter have several impairments, thus demonstrating that Alzheimer's disease considerably affects wellbeing among older adults.…”

Section: Direct and Indirect Approachesmentioning

confidence: 99%

Measurement, Data and Country Context

Mitra

2017

Disability, Health and Human Development

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This chapter gives the empirical background to the analysis in Chapters 4, 5 and 6. It first reviews measurement issues with respect to implementing the human development model of Chapter 2. There could be different ways to put the human development model into practice depending on the objective of the exercise and the context. This chapter discusses some ways to operationalize the model and explains the health and wellbeing deprivation measures that are adopted in the rest of this book. It describes the data under use (Living Standards Measurement Study) and the demographic, socioeconomic, and policy contexts for the countries covered in the analysis: Ethiopia, Malawi, Tanzania, and Uganda.Keywords Disability · Capability approach · Human development model · LSMS · Africa · Washington GroupThis chapter gives the empirical background to the analysis in Chapters 4, 5, 6. It first reviews measurement issues with respect to implementing the human development model of Chapter 2. Of course, there could be different ways to operationalize the human development model depending on the objective of the exercise and the context. In Sect. 3.1 below, CHAPTER 3

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Capability deprivation of people with Alzheimer's disease: An empirical analysis using a national survey

Cited by 17 publications

References 46 publications

Melatonin induces mechanisms of brain resilience against neurodegeneration

Melatonin induces mechanisms of brain resilience against neurodegeneration

Measuring capabilities in health and physical activity promotion: a systematic review

Measurement, Data and Country Context

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