Capability of novel fluorescence DNA-conjugated CdTe/ZnS quantum dots nanoprobe for COVID-19 sensing

Bardajee, Ghasem Rezanejade; Zamani, Mohammadreza; Mahmoodian, Hossein; Elmizadeh, Hamideh; Yari, Hadi; Jouyandeh, Lavin; Shirkavand, Razieh; Sharifi, Mahdieh

doi:10.1016/j.saa.2021.120702

Cited by 24 publications

(16 citation statements)

References 21 publications

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“…319 When high-energy electrons of QD relax into holes, they emit electromagnetic radiation in the NIR or UV region of the electromagnetic spectrum. 320 This energy gradient is responsible for the attractive properties of QDs such as Stokes shift in fluorescent sensors [321][322][323][324] or photocurrent in photoelectrochemical (PEC) sensors. 286,287,325 Such a Stokes shift enhances the signal to noise ratio which in turn enables high luminescence that can allow the detection of the highly infectious NoV at very low concentrations (4.3 Â 10 5 particles mL À1 ).…”

Section: As Wellmentioning

confidence: 99%

“…322,330 CdTe/ZnS QD nanoprobes employed in FRET-based COVID-19 detection confirm the results of PCR, thus presenting a convenient and cheaper alternative. 324 CdTe QD decorations impart fluorescence to MIPs which can simultaneously detect hepatitis A virus (HAV) and HBV within 20 minutes due to virus-induced quenching. 330 Zinc-doped CdTe QDs can act as supports for the immobilization of black-hole quenchers to inhibit over-valency and allow single-particle detection.…”

Section: Inorganic Nanomaterials In Virus Sensing and Trackingmentioning

confidence: 99%

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Nanomaterials for virus sensing and tracking

Pirzada

Altıntaş

2022

Chem. Soc. Rev.

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Section: As Wellmentioning

confidence: 99%

Section: Inorganic Nanomaterials In Virus Sensing and Trackingmentioning

confidence: 99%

Nanomaterials for virus sensing and tracking

Pirzada

Altıntaş

2022

Chem. Soc. Rev.

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“…Among the candidate materials, quantum dots (QDs) with the features of good dispersion, high quantum yield, stable optical activity, and excellent photoluminescence performance have garnered much interest [ 37 ]. For example, Bardajee et al designed CdTe-ZnS QDs functioned with DNA (QDs-DNA) to specifically recognize the DNA or RNA of the COVID-19 virus via the FRET method [ 38 ]. The QDs-DNA acts as a donor molecule, and the BHQ 2 -DNA was prepared to act as an acceptor molecule in the FRET process, as can be seen in Figure 2 a.…”

Section: Fluorescence Biosensor For Sars-cov-2 Diagnosismentioning

confidence: 99%

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Lin

et al. 2022

Biosensors

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The outbreak of Corona Virus Disease 2019 (COVID-19) has again emphasized the significance of developing rapid and highly sensitive testing tools for quickly identifying infected patients. Although the current reverse transcription polymerase chain reaction (RT-PCR) diagnostic techniques can satisfy the required sensitivity and specificity, the inherent disadvantages with time-consuming, sophisticated equipment and professional operators limit its application scopes. Compared with traditional detection techniques, optical biosensors based on nanomaterials/nanostructures have received much interest in the detection of SARS-CoV-2 due to the high sensitivity, high accuracy, and fast response. In this review, the research progress on optical biosensors in SARS-CoV-2 diagnosis, including fluorescence biosensors, colorimetric biosensors, Surface Enhancement Raman Scattering (SERS) biosensors, and Surface Plasmon Resonance (SPR) biosensors, was comprehensively summarized. Further, promising strategies to improve optical biosensors are also explained. Optical biosensors can not only realize the rapid detection of SARS-CoV-2 but also be applied to judge the infectiousness of the virus and guide the choice of SARS-CoV-2 vaccines, showing enormous potential to become point-of-care detection tools for the timely control of the pandemic.

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“…[ 30 ] Also, due to the high affinity of Cd ions with organic molecules, the biomedical applications of this class of MCQDs have reaped a lot of attention. [ 19 ] However, while having high performance, MCQDs containing Cd and Pb have inherent high toxicity due to the fact that Cd or Pb ions can leak during the degradation of MCQDs in vivo, causing severe toxicity. [ 31 ] For this class of MCQDs, toxicity is the key issue that needs to be addressed more than optical performance or other properties.…”

Section: Properties and Synthesis Of Mcqdsmentioning

confidence: 99%

“…To date, there is still much biomedical research being conducted using Cd‐based QDs and achieved great performances. [ 19,32,90 ]…”

Section: Challenges For Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Metal Chalcogenide Quantum Dots: From Material Design to Biomedical Applications

Piao

Yang

Cui

et al. 2022

Adv Funct Materials

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With the rapid progress in nanomaterials and biochemistry, there has been an explosion of interest in biomolecule-modified quantum dots (QDs) for biomedical applications. Metal chalcogenide quantum dots (MCQDs), as the most widely studied QDs, have attracted tremendous attention in the biomedical field on account of their unique and excellent optical properties and the ease of biomolecular modifications. Herein, important advances in MCQDs over recent years are reviewed, from materials design to biomedical applications. Especially, this review focuses on the challenges encountered in the applications of MCQDs in biomedical fields and how these problems can be solved by rational design of synthesis methods and modifications, which have opened a universal route to develop the functionalized MCQDs. Moreover, recent processes in bioimaging, biosensing, and cancer therapy based on MCQDs are examined, including the rapid detection and diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review provides broad insights into MCQDs in the biomedical field and will inspire material researchers to develop MCQDs in the future.

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Capability of novel fluorescence DNA-conjugated CdTe/ZnS quantum dots nanoprobe for COVID-19 sensing

Abstract: Graphical abstract

Cited by 24 publications

References 21 publications

Nanomaterials for virus sensing and tracking

Nanomaterials for virus sensing and tracking

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Recent Advances in Metal Chalcogenide Quantum Dots: From Material Design to Biomedical Applications

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