Capacitive contact lens sensor for continuous non-invasive intraocular pressure monitoring

Chen, Guo Zhen; Chan, Ion Seng; Lam, David Chuen Chun

doi:10.1016/j.sna.2013.08.029

Cited by 113 publications

(132 citation statements)

References 21 publications

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“…The intraocular pressure is a primary indicator of glaucoma, the second leading cause of blindness. Sensors that offer wireless, continuous measurement are crucial because peaks in intraocular pressure might occur during sleep time, and not necessarily during daytime checkup . A flexible bioresorbable piezoresistive sensor implant was used to monitor physiological forces in vivo in mice .…”

Section: Applications Of Pressure Sensors In Monitoring Body Motionmentioning

confidence: 99%

Flexible Pressure Sensors for Objective Assessment of Motor Disorders

Amit

Chukoskie

Skalsky

et al. 2019

Adv Funct Materials

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Monitoring body motion is relevant to motor control disorders as well as assessment of fine motor skills in child development. Furthermore, motion tracking is necessary for rehabilitation monitoring and injury prevention and benefits both sick and healthy individuals. Flexible pressure sensors based on resistors, capacitors, inductors, or transistors are reviewed in the context of healthcare measurements, ranging from physiological signals to body movement characteristics such as grip and gait. To demonstrate the use of flexible pressure sensors for motor assessment, a touch sensing glove that evaluates fine motor skills in autism research is developed. The results show that autistic children perform fewer taps per minute compared to typically developing children, with larger variations in tap durations. In a second example, a force and motion sensing glove is developed to assess spasticity, a neuromuscular disorder that causes muscle stiffness/resistance and jerky movement. Analyses of force versus velocity show movement-dependent muscle resistance in a patient with spasticity. Through these flexible sensor systems, the shift from subjective scores to objective measurement will promote better diagnosis and dramatically improve the accuracy in tracking patient response to therapy.patients doing certain movements, and then clinicians rank each patient's level according to qualitative descriptions in benchmark classification scales. [12,13] The subjective scores can be inconsistent between raters and do not capture finelevel changes in a patient's progress in response to therapy. Therefore, there is a critical need to tackle the issue of imprecise assessment of motor disorders.With recent advances in flexible sensors and innovations in tactile sensing, [14][15][16][17][18][19] we have new low-cost technologies that are prime to facilitate quantitative evaluation of motor control. This progress report presents current developments in wearable sensor systems applicable to motor disorders, so that consistent, objective metrics become available to accurately track whether a treatment effectively relieves symptoms. The wearable sensors are not limited to placement on patients but can also be worn by clinicians or caregivers to assist them in taking measurements during patient interactions. [20,21] The point-of-care sensor systems will allow frequent monitoring, which is highly desirable to offer a better understanding of the patient's short and long-term response to therapies, to tailor treatment and improve outcome and quality of life for patients.Other reviews [14][15][16][17][18][19] have already extensively covered the flexible materials and devices used in tracking vital signs and electronic skin applications. In light of that, this progress report focuses on the applications in monitoring motor skills, in particular to implement pressure sensor designs for wearable systems with diverse form factors, for instance, gloves, [20,22,23] epidermal tags tags, [24,25] and shoe insoles. [26,27] We will discuss the mechanis...

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Section: Applications Of Pressure Sensors In Monitoring Body Motionmentioning

confidence: 99%

Flexible Pressure Sensors for Objective Assessment of Motor Disorders

Amit

Chukoskie

Skalsky

et al. 2019

Adv Funct Materials

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“…Moreover, the design also had the capability to track pressure variation profiles with minimal lag. 40 In addition, noninvasive contact lens sensors have been developed by using a piezoresistive sensing system. Laukhin et al 41 designed a flexible piezoresistive bilayer with a polycarbonate [poly-(bisphenol-A-carbonate)] matrix and a conducting top layer composed of organic molecular metal β-(ET) 2 I 3 .…”

Section: Intraocular Pressure Monitoringmentioning

confidence: 99%

Nanotechnology Applications for Glaucoma

Çetinel

Montemagno²

2016

Asia-Pacific Journal of Ophthalmology

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Glaucoma is the second leading cause of blindness worldwide, and the antiglaucoma treatments currently available suffer from various complications. Nanotechnology-based treatments show a great deal of promise in overcoming these complications and form the basis for next-generation glaucoma treatment strategies, with the help of applications such as controlled release, targeted delivery, increased bioavailability, diffusion limitations, and biocompatibility. Significant progress has been made in nanomedicine in the efficiency of antiglaucoma medications, nanofabrication systems such as microelectromechanical systems that remove the limitations of nanodevices, and tissue regeneration vesicles for developing glaucoma treatments not based on intraocular pressure. With the use of these advanced technologies, the prevention of glaucoma-induced blindness will be possible in the near future. Herein, we reviewed the recent advances in nanotechnology-based treatment strategies for glaucoma.

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“…3A) and shown to have advantageous properties such as high sensitivity to pressure changes, low temperature sensitivity, and low consumed power, making it more suitable for implantation. 75,77 Radiowave telemetry is also used in the wireless IOP transducer (WIT) (Implandata GmbH, Hannover, Germany) that is an implantable microstructured device consisting of 2 parts, an ASIC chip and a microcoil antenna, with a pressure, temperature, an identification encoder, an analog-to-digital converter, and telemetry into a single implantable microchip (Fig. 3C) for continuously monitoring IOP was shown to have the capability to track pressure variation profiles with minimal lag.…”

Section: Nanotechnology Diagnostic Approachesmentioning

confidence: 99%

Nanotechnology-Based Approaches for Ophthalmology Applications

Sharaf¹,

Çetinel²,

Heckler³

et al. 2014

Asia-Pacific Journal of Ophthalmology

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The pursuit of personalized medicine approaches for combating ocular diseases may be possible only through the development of nanotechnology platforms that include molecular-level engineering. Nanoparticle engineering is a common thread; herein, we attempt to show unmodified nanoparticles as well as interesting and representative biomimetic strategies can be used for specific diseases. Finally, through combining microelectromechanical and nanoelectromechanical manufacturing system strategies, interesting manufacturing and sensor development can be accomplished for early detection and, in some cases, treatment of ocular diseases.

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Capacitive contact lens sensor for continuous non-invasive intraocular pressure monitoring

Cited by 113 publications

References 21 publications

Flexible Pressure Sensors for Objective Assessment of Motor Disorders

Flexible Pressure Sensors for Objective Assessment of Motor Disorders

Nanotechnology Applications for Glaucoma

Nanotechnology-Based Approaches for Ophthalmology Applications

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