Capacitive Sensing of Amino Acids Using Caliraxene‐Coated Silicon Transducers

Ijeri, Vijaykumar S.; Vocanson, Francis; Martelet, C.; Jaffrézic‐Renault, Nicole

doi:10.1002/elan.200603729

Cited by 12 publications

(8 citation statements)

References 41 publications

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“…By immobilizing calix [4]arene derivatives on Si/SiO 2 /Si 3 N 4 transducers, sensors were obtained with the ability of using capacitance and flat band voltage as measurable quantities for determining amino acids that are neither electroactive nor having strong UV-vis absorption. 56 Different calixarene derivatives showed varying sensitivities to the amino acids which ranged from 8 to 137 mV decade À1 .…”

Section: Recognition Of Amino Acids By Calix[n]arenes Derivativesmentioning

confidence: 99%

Recognition of amino acids by functionalized calixarenes

et al. 2011

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The calixarenic receptors exhibit remarkable host-guest properties towards biologically relevant guests. Aspects of complex formation reactions between both native and derivatized amino acids, di-and tripeptides with calixarenic (chiral or not) receptors are summarized in this critical review. Thus, the discussions emphasize the parameters that affect the molecular binding selectivity and efficiency of functionalized calix[n]arenes towards these substrates. A brief survey on their application in separation of amino acids is also considered (123 references).

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Section: Recognition Of Amino Acids By Calix[n]arenes Derivativesmentioning

confidence: 99%

Recognition of amino acids by functionalized calixarenes

et al. 2011

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“…2022, 12, x FOR PEER REVIEW 2 of 32 lanthanide ions [3]. Ethyleneoxy moiety (CH2CH2O-) is a crucial repeated unit of simple crown ether: repeated twice in dioxane and six times in 18-crown-6 [4]. These can be either substituted or unsubstituted and possess a hydrophobic ring surrounding a hydrophilic cavity, enabling them to form stable complexes with metal ions and contributing to host-guest chemistry [1,5].…”

Section: M(s) + L→mmentioning

confidence: 99%

“…For example, 18-crown-6 has a cavity that fits the size of 4f transition metal ions and has reflected exceptional attraction for complexation with the lanthanide ions [3]. Ethyleneoxy moiety (CH 2 CH 2 O-) is a crucial repeated unit of simple crown ether: repeated twice in dioxane and six times in 18-crown-6 [4].…”

Section: Introductionmentioning

confidence: 99%

Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications

et al. 2022

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Cyclic organic compounds with several ether linkages in their structure are of much concern in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely versatile compounds exhibiting higher binding affinity. In recent years, due to their unique structure, crown ethers are widely used in drug delivery, solvent extraction, cosmetics manufacturing, material studies, catalysis, separation, and organic synthesis. Beyond their conventional place in chemistry, this review article summarizes the synthesis, biological, and potential pharmacological activities of CEs. We have emphasized the prospects of CEs as anticancer, anti-inflammatory, antibacterial, and antifungal agents and have explored their amyloid genesis inhibitory activity, electrochemical, and potential metric sensing properties. The central feature of these compounds is their ability to form selective and stable complexes with various organic and inorganic cations. Therefore, CEs can be used in gas chromatography as the stationary phase and are also valuable for cation chromatographic to determine and separate alkali and alkaline-earth cations.

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“…In the classical approach, the semiconductor devices and/or samples tested are functionalized with receptor/binder materials (e.g. enzymes) 9 to enable the sensing via the measurement of current-2 , capacitance- 10 , or resistance-change 6 , which are then directly correlated to the concentration of the species of interest. One faces here two contrasting tendencies.…”

Section: Introductionmentioning

confidence: 99%

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

Alkhidir

Jaoudé

Gater

et al. 2020

Journal of Vacuum Science &Amp; Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phen

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Most current techniques for analyzing amino acids require substantial instrumentation and significant sample preprocessing. In this study, we designed, fabricated and tested a scalable diode-based microdevice that allows for direct sensing of amino acids. The device is based on modulation-doped GaAs heterostructure with a Schottky contact on one side. The relatively high mobility and relatively small dielectric constant of GaAs are naturally helpful in this problem. We also paid attention to a proper etching procedure allowing for substantial modification of the surface properties, thereby further boosting the sensing performance. Transport data (I-V, differential conductance) are presented for three qualitatively different classes of amino acids (i.e. non-polar with aliphatic R-group, polar uncharged R-group and charged R-group) with glycine, cysteine and histidine as specific examples, respectively. The conductance for the GaAsamino acid interface measured using scanning tunneling microscope (STM) was previously reported to have distinct spectral features. In this paper, we show that measuring the differential conductance of GaAs diode whose surface is in direct contact with an aqueous solution of amino acid, is a simple methodology to access useful information, previously available only through sophisticated and equipment-demanding STM and molecular electronics approaches. Density functional theory (DFT) calculations were used to examine which adsorption processes were likely responsible for the observed surface conductance modification. Lastly, in future and ongoing work, we illustrate how it might be possible to employ standard multivariate data analysis techniques to reliably identify distinct (95%) single amino acid specific features in near-ambient differential conductance data. Research questions we address here are: (1) is it possible to distinguish between different amino acids in contact with the same GaAs interface, based on I-V curves?; (2) how are partial charges specific to individual amino acids?; (3) what are the likely binding mechanisms (individual amino acid to GaAs)?; and (4) to what extent one can use differential conductance data? We show how it is possible to distinguish between separate aqueous solutions of the amino acids in in-This is the author's peer reviewed, accepted manuscript. However, the online version of record will be different from this version once it has been copyedited and typeset.

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Capacitive Sensing of Amino Acids Using Caliraxene‐Coated Silicon Transducers

Cited by 12 publications

References 41 publications

Recognition of amino acids by functionalized calixarenes

Recognition of amino acids by functionalized calixarenes

Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

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