Capilaroscopia periungueal: importância para a investigação do fenômeno de Raynaud e doenças do espectro da esclerose sistêmica

Kayser, Cristiane; Andrade, Luís Eduardo Coelho

doi:10.1590/s0482-50042004000100009

Cited by 6 publications

(5 citation statements)

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“…Currently, two methods are most used for performing NFC: panoramic nailfold capillaroscopy, using a stereomicroscope, and videocapillaroscopy, which uses larger magnifications and a computerized system of image acquisition. 3 Both have advantages and disadvantages; however, they are equivalent for the identification of classical abnormalities, allowing the recognition of three patterns: normal pattern, nonspecific microangyopathy and SD pattern. 23 The inclusion of capillaroscopic abnormalities in the new classification criteria of the ACR/EULAR for SSc gives a new impetus to the use and dissemination of capillaroscopy.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 The history of capillaroscopy started 400 years ago, when JC Kolhaus described the possibility of visualization of capillary loops of the nailfold region through a rudimentary system of optical magnification. 3 However, only in the second half of the 20th Century NFC begins to be used more systematically in the evaluation of RP, in particular, thanks to the studies of Hildegard Maricq and Edward Carwile LeRoy, who described in 1973 specific capillaroscopic patterns of SSc and related diseases. 4 In Brazil, the method was introduced and standardized in the 80s by Luís Eduardo Coelho Andrade.…”

Section: Introduction and Brief Historymentioning

confidence: 99%

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Nailfold capillaroscopy: relevance to the practice of rheumatology

Souza

Kayser

2015

Revista Brasileira de Reumatologia (English Edition)

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r e v b r a s r e u m a t o l . 2 0 1 5;5 5(3):264-271 w w w . r e u m a t o l o g i a . c o m . b r a b s t r a c t Nailfold capillaroscopy is a simple, low-cost method, that is extremely important in the evaluation of patients with Raynaud's phenomenon and of patients with systemic sclerosis (SSc) spectrum diseases. Besides its importance for the early diagnosis of SSc, nailfold capillaroscopy is a useful tool to identify scleroderma patients with high risk for development of vascular and visceral complications and death. The inclusion of capillaroscopy in the new classification criteria for SSc of the American College of Rheumatology (ACR) and European League Against Rheumatism (Eular) gives a new impetus to the use and dissemination of the method. In this paper, we present a didactic, non-systematic review on the subject, with emphasis on advances recently described. Capilaroscopia periungueal: relevância para a prática reumatológica Palavras-chave: Capilaroscopia Fenômeno Raynaud Esclerose sistêmica r e s u m o A capilaroscopia periungueal é um método simples, de baixo custo, e de extrema relevância na avaliação de pacientes com fenômeno de Raynaud ou portadores de doenças do espectro da esclerose sistêmica (ES). Além de sua importância para o diagnóstico precoce da ES, constitui instrumento útil na identificação de pacientes esclerodérmicos com risco elevado para o desenvolvimento de complicaç ões vasculares, viscerais e de óbito. A inclusão da capilaroscopia nos novos critérios para classificação da ES do Colégio Americano de Reumatologia (ACR) e da Liga Europeia Contra o Reumatismo (Eular) dá novo impulso para a utilização e disseminação do método. No presente artigo, pretendemos apresentar uma revisão didática, não sistemática, sobre o tema, com ênfase nos avanços recentemente descritos. r e v b r a s r e u m a t o l . 2 0 1 5;5 5(3):264-271

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Section: Discussionmentioning

confidence: 99%

Section: Introduction and Brief Historymentioning

confidence: 99%

Nailfold capillaroscopy: relevance to the practice of rheumatology

Souza

Kayser

2015

Revista Brasileira de Reumatologia (English Edition)

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“…Periungual capillary was performed by a single observer using a Colemam stereomicroscope apparatus with low heat radiation source, using a 10-fold increase 9 . After dipping the area to be studied in drying enamel oil, we analyzed the periungual bed from the 2nd to 5th digits of both hands, proceeding to count the number of loops per millimeter (mm) and observing the presence of deletions and changes in capillary morphology.…”

Section: Methods Methods Methods Methodsmentioning

confidence: 99%

“…After dipping the area to be studied in drying enamel oil, we analyzed the periungual bed from the 2nd to 5th digits of both hands, proceeding to count the number of loops per millimeter (mm) and observing the presence of deletions and changes in capillary morphology. We considered the absence of at least two successive capillary as a deletion or avascular focus 9 . For statistical purposes, the count value used for each subject was the mean of all the analyzed nails.…”

Section: Methods Methods Methods Methodsmentioning

confidence: 99%

Avaliação da capilaroscopia usando Endotelina-1 como um marcador de ativação endotelial na lesão microvascular e úlceras cutâneas

Michaelis¹,

Andretta²,

Albers³

et al. 2012

Rev. Col. Bras. Cir.

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OBJETIVO: Avaliar a presença da ET-1 em pacientes portadores de esclerodermia e a sua correlação com o nível de atividade da doença; verificar se os níveis de endotelina estão associados com o perfil clínico e de autoanticorpos da esclerodermia e, ainda, se há associação com lesão microvascular detectada pela capilaroscopia periungueal. MÉTODOS: Um total de 74 pacientes, sendo 37 portadores de esclerodermia e o restante controle, foram submetidos à dosagem de ET-1 por meio de teste de ELISA. Pacientes com esclerodermia foram analisados através de um questionário sobre características da doença e pesquisa de autoanticorpos. A gravidade da doença foi definida pelos critérios de Medsger e a doença microvascular foi acessada através de capilaroscopia periungueal. RESULTADOS: Dos 37 pacientes com esclerodermia três (8,1%) eram homens e 34 (91,89%) mulheres, com idade média de 48,97 ? 13,36 anos e tempo médio de doença de 42,54 ? 13,35 anos. Os valores da ET-1 nos controles foram de 0,41 a 5,65 pg/ml (mediana de 2,26 pg/ml) e nos com esclerodermia de 0,41 a 8.82 pg/ml (mediana de 0,41 pg/ml) com p de 0,0007. Não houve correlação com o tempo de doença, idade do paciente e com o nível de acometimento cutâneo. Não encontrou-se correlação entre nível de ET-1 sérica e gravidade da doença (p=0,13). Níveis maiores de ET-1 foram observados na forma de superposição (1,49 a 6,82 pg/ml). CONCLUSÃO: Os níveis de ET-1 em esclerodérmicos mostraram-se inferiores aos controles. Não houve associação dos níveis de ET-1 com as variáveis estudadas.

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“…Endothelial cells play an important role in pathogenesis of psoriasis as immune-mediated inflammatory features and papillary dermis have multiple blood vessels, as well as they show microvascular changes such as decreased capillary density and avascular areas. Additionally, NVC can provide some information regarding morphostructural changes of capillaries including tortuosity, elongation, dilatation, and crosslinked [11][12][13][14][15]. Several studies with capillaroscopy have been performed in patients with psoriasis, with either nail or joint involvement [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

Üreyen¹,

Kara²,

Ertürk³

et al. 2018

Med Ultrason

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Objective: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs).Material and methods: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects. The nail plate thickness (NPT) was measured on gray scale using US. The NVRI was measured using color Doppler (CD) US. The measurements of the apical, arterial, venous limb diameters and morpho-structural changes (tortuous, cross-linked capillaries) were assessed using NVC.Results: Thirty-four patients with PND and 15 HCs were enrolled in this study. The two groups were matched for age and body mass index (BMI). Patients with PND had higher NPT and NVRI in comparison with HCs [(20 (17-23) vs 14 (14-15), p<0.001), (0.55 (0.51-0.61) vs 0.43 (0.38-0.49), p<0.001), respectively]. A higher proportion of patients with PND had tortuous capillaries than HCs (62% and 20% respectively, p=0.005). The mean NVRI was higher in patients with PND who had tortuous capillaries than patients who did not have tortuous capillaries (0.58 (0.7) and 0.52 (0.09), respectively p=0.033).Conclusion: Microvascular changes can be detected easily using non-invasive methods such as US and NVC. These methods can provide an objective data to better assess PND.

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Capilaroscopia periungueal: importância para a investigação do fenômeno de Raynaud e doenças do espectro da esclerose sistêmica

Abstract: ABSTRACT

Cited by 6 publications

References 19 publications

Nailfold capillaroscopy: relevance to the practice of rheumatology

Nailfold capillaroscopy: relevance to the practice of rheumatology

Avaliação da capilaroscopia usando Endotelina-1 como um marcador de ativação endotelial na lesão microvascular e úlceras cutâneas

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

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