Capillaria hepatica (syn. Calodium hepaticum) as a Cause of Asymptomatic Liver Mass

Manor, Uri; Doviner, Victoria; Kolodziejek, Jolanta; Weidinger, Pia; Dagan, Amir; Ben-Haim, Menahem; Rokah, Merav; Nowotny, Norbert; Boleslavsky, Daniel

doi:10.4269/ajtmh.21-0120

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…The eggs are retained in the liver until the animal dies, and then released into the environment, as predators or scavengers (first accidental host) ingest the definitive host, and the cycle continues repeatedly [ 58 ]. In humans, the larvae hatch in the intestine, and juveniles migrate to the liver, mature, mate, and lay eggs, causing granuloma formation, liver necrosis [ 58 , 59 ] and lesions [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Capillaria aerophila Creplin, 1839) Worldwide Wild carnivores, dogs, cats, humans Ingestion of embryonated eggs [ 67 ] France, Iran, Morocco, Russia, Serbia, Ukraine Carnivorous mammals Cats [ 68 ] Calodium hepaticum (Bancroft, 1893) Moravec, 1982 (syn. Capillaria hepatica Bancroft, 1893) Worldwide Murid rodents and various other mammals Consumption of unembryonated eggs in soil or infected game [ 69 ] Argentina, France Human, rodent, camelid ND [ 70 ] Brazil, Canada, Czechoslovakia, England, Germany, Greece, Italy, Mexico, New Zealand, Nigeria, India, Ivory Coast, Japan, Republic of Korea, South Africa, Switzerland, Thailand, Turkey, USA, Yugoslavia Marsupials, carnivores, hominids and other mammals The consumption of infected game or from soil [ 58 ] China Human – [ 60 ] Israel Human – [ 59 ] Iran Human – [ 57 ] C. philippinensis Velasquez, Chitwood and Salazar, 1968 The Philippines, Thailand, Japan, Iran, Egypt, China Human Raw fish [ 71 ] …”

Section: Resultsmentioning

confidence: 99%

“…In humans, this worm is responsible for uncommon cases of hepatic capillariosis and spurious infections in patients [ 177 ]. It is found throughout the world, and human infection cases of C. hepaticum have been documented in different regions of Africa, Asia, Europe, North and South America, and Oceania (see Additional file 1 : Figure S3), with 163 individuals affected [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

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Human parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control

Intirach,

Shu,

et al. 2024

Infect Dis Poverty

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Background Human parasitic infections caused by Adenophorean nematodes encompass a range of diseases, including dioctophymiasis, trichuriasis, capillariasis, trichinellosis, and myositis. These infection can result in adverse impacts on human health and cause societal and economic concerns in tropical and subtropical regions. Methods This review conducted searches in PubMed, Embase and Google Scholar for relevant studies that published in established databases up to April 26, 2024. Studies that focused on the common morphology, life cycle, disease distribution, clinical manifestations, and prevention and control strategies for Adenophorean parasitic diseases in humans were included. Results Adenophorean nematodes exhibit shared morphological characteristics with a four-layered cuticle; uninucleate epidermal cells; pseudocoelom with six or more coelomocytes; generally three caudal glands; five esophageal glands; two testes in males with median-ventral supplementary glands in a single row; tail in males rarely possessing caudal alae; amphids always postlabial; presence of cephalic sensory organs; absence of phasmids; and a secretory-excretory system consisting of a single ventral gland cell, usually with a non-cuticularized terminal duct. Humans play two important roles in the life cycle of the nematode class, Adenophorea: 1) as a definitive host infected by ingesting undercooked paratenic hosts, embryonated eggs, infective larvae in fish tissue and meat contaminated with encysted or non-encysted larvae, and 2) as an accidental host infected by ingesting parasitic eggs in undercooked meat. Many organs are targeted by the Adenophorean nematode in humans such as the intestines, lungs, liver, kidneys, lymphatic circulation and blood vessels, resulting in gastrointestinal problems, excessive immunological responses, cell disruption, and even death. Most of these infections have significant incidence rates in the developing countries of Africa, Asia and Latin America; however, some parasitic diseases have restricted dissemination in outbreaks. To prevent these diseases, interventions together with education, sanitation, hygiene and animal control measures have been introduced in order to reduce and control parasite populations. Conclusions The common morphology, life cycle, global epidemiology and pathology of human Adenophorean nematode-borne parasitic diseases were highlighted, as well as their prevention and control. The findings of this review will contribute to improvement of monitoring and predicting human-parasitic infections, understanding the relationship between animals, humans and parasites, and preventing and controlling parasitic diseases. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Human parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control

Intirach,

Shu,

et al. 2024

Infect Dis Poverty

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Capillaria hepatica (syn. Calodium hepaticum) infection and factors influencing infection carriage in rats (Rattus spp.) in Hong Kong

Sandy,

Uea-Anuwong,

Kiu

et al. 2024

One Health

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Unveiling the hidden threats: a review of pathogen diversity and public health risks from bats, rodents, and non-human primates in Zambia (1990–2022)

Munjita,

Mubemba,

Changula

et al. 2024

Front. Public Health

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BackgroundInfectious disease agents of animal origin, which can cause mild to severe illnesses in humans, are increasingly spilling over into human populations. Southern Africa, particularly Zambia as a regional transport hub, has experienced notable outbreaks of zoonotic pathogens in recent years. This context underscores the importance of research, as numerous studies over the past 33 years have reported various infectious agents with differing zoonotic potential from bats, rodents, and non-human primates (NHPs) in Zambia. However, the data remained unaggregated, hampering comprehensive and organized understanding of these threats.MethodsA review spanning January 1990 to December 2022 synthesised data from selected studies conducted in bats, rodents, and NHPs across 14 of Zambia’s 116 districts.ResultsAmong the reported pathogens, viruses predominated (62%, 31/50), followed by parasites (20%, 10/50)), and bacteria (18%, 9/50). Notable pathogens included Ebola virus, Marburg virus, Hantavirus, Zika virus, Human parainfluenza virus-3, Anaplasma phagocytophilum, Borrelia faini, Coxiella burnetii, Trypanosoma brucei rhodesiense, Calodium hepaticum, and Trichinella spiralis. Most identified infectious agents came from short term cross-sectional investigations, thus, the temporal dynamics related to abundance and likelihood of outbreaks remain unknown.ConclusionThe findings starkly illuminate significant zoonotic public health threats amidst glaring under-surveillance of zoonoses in humans in Zambia. This critical gap calls urgently for enhanced active, passive and syndromic surveillance activities to identify new diseases and provide evidence-based measures to safeguard public health from emerging infectious risks in Zambia and the Southern African sub-region, considering the country’s position as a regional transport hub.

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Capillaria hepatica (syn. Calodium hepaticum) as a Cause of Asymptomatic Liver Mass

Cited by 3 publications

References 17 publications

Human parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control

Human parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control

Capillaria hepatica (syn. Calodium hepaticum) infection and factors influencing infection carriage in rats (Rattus spp.) in Hong Kong

Unveiling the hidden threats: a review of pathogen diversity and public health risks from bats, rodents, and non-human primates in Zambia (1990–2022)

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