Capillaroscopy

Cutolo, Maurizio; Pizzorni, Carmen; Secchi, Maria Elena; Sulli, Alberto

doi:10.1016/j.berh.2008.09.001

Cited by 147 publications

(137 citation statements)

References 28 publications

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“…Score for irregularly enlarged capillaries, capillaries loss, disorganization of the microvascular array and capillary ramifications were found to have increased, while scores for giant capillaries and hemorrhages decreased during follow-up. A 4% variability was found in the score assessment by the different evaluators [43], [44] and [45].…”

Section: Secondary Rpmentioning

confidence: 93%

The role of nail-videocapillaroscopy in early diagnosis of scleroderma

Rossi

Russo

Manna

et al. 2013

Autoimmunity Reviews

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Raynaud's phenomenon (RP) is a clinical sign of precocious abnormal microcirculation and can be considered a major risk factor for the development of connective tissue disease, especially systemic sclerosis (SSc). Nailfold videocapillaroscopy is the most valuable tool for the early diagnosis of SSc and related disorders. It allows classification of capillary abnormalities. Scoring capillaroscopic alterations, which change significantly during patient follow-up, should be systematically used in order to monitor microangiopathy. The effectiveness of the nailfold videocapillaroscopy in allowing an early diagnosis of SSc and monitoring the progression of the disease, and its predictive value of clinical complications make it a powerful tool for clinical evaluation and research.

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Section: Secondary Rpmentioning

confidence: 93%

The role of nail-videocapillaroscopy in early diagnosis of scleroderma

Rossi

Russo

Manna

et al. 2013

Autoimmunity Reviews

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“…The frequency of hemorrhages is significantly higher in the fourth fingers than in the other fingers with naked eyes [23]. The most accurate morphological assessment with dermatoscope is commonly performed on the fourth and fifth fingers, because of the greater transparency of the skin on these fingers [6]. Consistent with this, the frequency of enlarged capillaries and hemorrhages was the highest in the fourth fingers from SSc patients.…”

Section: Discussionmentioning

confidence: 74%

“…It has been suggested that enlarged capillaries represent a local autoregulatory response to tissue hypoxia [5]. The dilation may represent the first sign of vessel wall damage, and the increased red color is related to the greater number of red blood cells [6]. Local hemorrhages is also linked to the damage of the vessel wall [6].…”

Section: Introductionmentioning

confidence: 99%

“…The dilation may represent the first sign of vessel wall damage, and the increased red color is related to the greater number of red blood cells [6]. Local hemorrhages is also linked to the damage of the vessel wall [6]. The presence of capillary abnormalities may aid in early diagnosis of SSc, dermatomyositis, and mixed connective tissue disease and in the differential diagnosis of primary Raynaud's phenomenon from Raynaud's phenomenon due to SSc and mixed connective tissue disease [3,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The following two parameters were considered and counted, according to previous classifications: enlarged capillaries and hemorrhages with either naked eyes or DermLite ® DL100 ( Fig. 1) [6]. The number more than six was recorded as six.…”

Section: Introductionmentioning

confidence: 99%

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A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients with systemic sclerosis

et al. 2010

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Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. The presence of nailfold capillary abnormalities is useful in diagnosing SSc. Capillaroscopy, however, usually requires special equipment and may be time consuming. Dermatoscope has been presented as a new diagnostic tool for quick and efficient examination of nailfold capillaries for circumstances when standard microscope equipment is not available. To assess the practical utility of dermatoscope for assessment of capillary morphology in SSc patients, 83 Japanese SSc patients (68 women, 15men) and 68 healthy controls were examined in the study. Twenty-one patients (16 women, 5 men) had diffuse cutaneous SSc and 62 (52 women, 10 men) had limited cutaneous SSc. Enlarged capillaries and hemorrhages were evaluated in all 10 fingers with either naked eyes or DermLite ® DL100 dermatoscope. Enlarged capillaries and hemorrhages were significantly more frequently detected with dermatoscope than without it. These findings were observed most frequently in the fourth finger. The presence of two or more enlarged capillaries in one or more fingers showed 83.1% sensitivity and 100% specificity for SSc. Among SSc patients with anti-topoisomerase I antibody, the disease duration correlated negatively with the dermatoscopic number of enlarged capillaries and hemorrhages. Dermatoscope allows the easy and rapid identification of capillary nailfold morphological changes in SSc and should be routinely used for diagnosing SSc.3

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Nail Bed Hemorrhage

Park

Park²,

Oh³

et al. 2011

Arch Ophthalmol

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To examine the characteristics of nailfold capillary changes in patients with glaucoma and to analyze their possible relationship to other clinical characteristics of glaucoma. Methods: One hundred eight glaucoma patients and 38 control patients were enrolled in the study. Eighty-six patients were classified as having normal tension glaucoma and 22 patients as having primary open-angle glaucoma. All patients underwent a complete ophthalmic examination and then a physical examination (in the rheumatology department) and were questioned regarding a history of systemic symptoms. Nailfold capillaroscopy was performed, and the results were analyzed by a single observer in a masked manner. Both the 2 test and multivariate logistic regression analysis were performed to determine which ocular characteristics were associated with the findings of nailfold capillaroscopy. Results: In the glaucoma patients, 55.6% showed dilated vessels, 35.2% showed loss of capillaries, and 19.4% showed nail bed hemorrhages by nailfold capillaroscopy. Disc hemorrhage was significantly associated with avascular area (odds ratio, 11.13; P Ͻ.001) and nail bed hemorrhage (81.59; PϽ.001). By multivariate logistic regression analysis, avascular area and nail bed hemorrhage continued to be independently associated with the presence of disc hemorrhages in glaucoma patients. No significant differences of association were found between patients having normal tension glaucoma and those having primary open-angle glaucoma. Conclusions: Nailfold capillaroscopy may give valuable information about some features of patients with glaucoma. Nail bed hemorrhage and loss of nail capillaries were strongly associated with the presence of optic disc hemorrhage, and the association was stronger with nail bed hemorrhage. No differences were observed between patients with normal tension glaucoma and patients with primary open-angle glaucoma.

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Capillaroscopy

Cited by 147 publications

References 28 publications

The role of nail-videocapillaroscopy in early diagnosis of scleroderma

The role of nail-videocapillaroscopy in early diagnosis of scleroderma

A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients with systemic sclerosis

Nail Bed Hemorrhage

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