Capillary beta-hydroxybutyrate determination for monitoring diabetic ketoacidosis

Rodríguez-Merchán, Beatriz; Casteras, A.; Domingo, Eva; Nóvoa, Francisco José; López, Yaiza; Cabezas-Agrícola, José Manuel; Rivero, T. de Portugal Fernández del; Parramón, M.; Mesa, Jordi

doi:10.1016/j.endoen.2011.05.003

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…Negative correlations between serum BHB and pH (r = − 0.67) and serum BHB and bicarbonate (r = − 0.7) have also been reported [15]. With regard to capillary BHB, it was analyzed in a study on type 1 diabetes patients who developed DKA [22]. The study found correlations between capillary BHB and pH (r = − 0.56419; p < 0.0001) and capillary BHB and bicarbonate (r = − 0.24139; p = 0.0161).…”

Section: Discussionmentioning

confidence: 99%

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Comparisons of biochemical parameters and diabetic ketoacidosis severity in adult patients with type 1 and type 2 diabetes

2022

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Objective The aim of this study was to determine the differences in biochemical parameters and diabetic ketoacidosis (DKA) severity in adult patients with type 1 and type 2 diabetes and utilization of serum BHB as a biomarker for DKA resolution was also evaluated. Materials and methods This prospective observational study of type 1 or type 2 diabetes mellitus who were diagnosed with DKA between 01 October 2018 and 30 September 2020. The correlations between serum BHB, measured by the Ranbut assay, and pH, bicarbonate, and anion gap were examined. Results A total of 99 diabetes patients were diagnosed with DKA (mean age 39.4 years, 63.4% female, 53.6% T2DM). while infection was the most common precipitating factor in T2DM (43.4%), non-compliance with treatment was the most common precipitating factor in T1DM (43.5%). T1DM patients had more severe DKA more hypokalemia during treatment. However, there was no significant difference in mortality between type1 and type2 diabetes. The initial laboratories evaluation of patients did not significant differ between type1 and type2 diabetes. Serum BHB during treatment of DKA was significantly correlated with changes in serum bicarbonate (r = − 0.64), serum anion gap (r = 0.84), and venous pH (r = − 0.6). The serum BHB levels corresponding to HCO3 levels for DKA severity were 4.5, 5.7, and 5.9 mmol/L in mild, moderate, and severe DKA, respectively. The serum BHB level of < 1 mmol/L had 73.7% sensitivity and 100% specificity to predict DKA resolution. Median time to resolution of DKA was 12 h with an optimized BHB cut-off value of < 1 mmol/L. There were no significant difference in time to resolution of DKA in the patients with type 1 and type 2 diabetes. Conclusions There are no differences in DKA-related biochemical parameters between type 1 and type 2 diabetes patients. The present findings suggest that DKA should be assessed and treated similarly, regardless of its occurrence in type 1 or type 2 diabetes patients.

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Section: Discussionmentioning

confidence: 99%

“…These findings suggest that serum BHB can be used as a parameter for monitoring clinical symptoms in patients during DKA regardless of the type of diabetes. It should be noted that serum BHB provides better accuracy for assessment of DKA than capillary blood BHB [22], and the utilization of capillary blood BHB in this regard is unclear.…”

Section: Discussionmentioning

confidence: 99%

Comparisons of biochemical parameters and diabetic ketoacidosis severity in adult patients with type 1 and type 2 diabetes

2022

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“…Optium Xceed, Laboratorios Abbott, Chicago, Estados Unidos), el cual utiliza tiras reactivas específicas para cada determinación. Las tiras para βHB contenían la enzima deshidrogenasa hidroxibutirato que se oxida a acetoacetato, con la reducción simultánea de NAD + a NADH, lo que es proporcional a la concentración de βHB; el sistema es válido para las concentraciones de 0 a 6 mmol l -1 (18) .…”

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Indicadores de estrés en bovinos por el uso de prácticas de manejo en el embarque, transporte y desembarque

Larios-Cueto

Ramírez‐Valverde

Osorio

et al. 2019

Rev. Mex. Cienc. Pecu.

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El objetivo fue evaluar el efecto del estrés producido durante el transporte y prácticas de manejo antes o después del traslado de animales, en relación con indicadores fisiológicos y de comportamiento en bovinos al inicio de la etapa de finalización. Se utilizaron 124 toretes provenientes de los Estados de Veracruz y Chiapas, los cuales fueron transportados al estado de México para su finalización (500 y 851 km, 15 y 20 h, respectivamente). Los tratamientos fueron: 1) manejo de recepción al embarque en el lugar de origen (ME), 2) ME + aplicación de un β-bloqueador al embarque (MEβ), 3) manejo de recepción al desembarque en el corral de finalización (MD), y 4) MD + aplicación de un β-bloqueador al embarque (MDβ). Los datos fueron analizados con el procedimiento GLM de SAS. El peso vivo (PV) promedio disminuyó 42 kg por animal (11.3%) al desembarque, con una recuperación de 35 kg a los 10 días después del desembarque. Los toretes con MEβ tuvieron menos pérdidas de PV (37.6 kg) que los que recibieron ME o MDβ (47.5 y 44.5 kg), sin diferencias (P>0.05) con MD (38.7 kg). Los indicadores de estrés más importantes fueron los cambios en PV, ácidos grasos libres, glucosa y cortisol, detectándose diferencias (P<0.05) por tratamiento y origen de los animales; en los demás indicadores (β-hidroxibutirato, proteínas totales, y concentraciones de sodio y potasio) no se detectaron diferencias por efectos principales (P>0.05). Se recomienda aplicar el manejo MEβ y atender prioritariamente el periodo desde el embarque hasta el desembarque de los animales.

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Capillary beta-hydroxybutyrate determination for monitoring diabetic ketoacidosis

Cited by 2 publications

References 19 publications

Comparisons of biochemical parameters and diabetic ketoacidosis severity in adult patients with type 1 and type 2 diabetes

Comparisons of biochemical parameters and diabetic ketoacidosis severity in adult patients with type 1 and type 2 diabetes

Indicadores de estrés en bovinos por el uso de prácticas de manejo en el embarque, transporte y desembarque

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