Capillary blood collected on volumetric absorptive microsampling (VAMS) device for monitoring hydroxychloroquine in rheumatoid arthritis patients

Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption

“…The water loss slows down or stops most degradation and metabolic processes, thus usually increasing analyte stability and allowing storage at room temperature (RT) for long periods of time [15,16]. The small dried sample can be accommodated in very small storage spaces and be shipped safely and feasibly; it also reduces solvent consumption and is thus cheaper and more sustainable [17][18][19][20][21]. VAMS use in particular is designed to be easily automated, and to sample accurate blood volumes without bias due to variable hematocrit values, which is a major drawback of other microsampling techniques, such as dried blood spots (DBS) on cards [22,23].…”

“…Since VAMS was developed specifically for application to whole blood, volume accuracy is granted only for this matrix. Application to other biological fluids requires the study of absorbed volumes under different experimental conditions [19,24].…”

Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications

“…Microsampling techniques such as plasma extraction cards, VAMS, and CMS (Figs. A, B, and C) are employed to collect very small volumes (~10–100 µL) (Jonsson et al, ; Bowen et al, ; Jonsson et al, ; Chapman et al, ; White et al, ; Kar, Maiti, & Chakraborty, ; Spooner et al, ; Mercolini et al, ; Niu et al, ; Barco et al, ; van den Broek et al, ; Kita & Mano, ; Qu et al, ; Fang et al, ; Koponen et al, ), which greatly reduces exposure to biohazards, eliminates the need for a large number of satellite animals, and allows for the collection of samples from individuals who are not able to provide large sample volumes such as newborn infants, the elderly, and the critically ill (White et al, ).…”

“…This results in subsampling/punching of DBS, which is subject to hematocrit and chromatographic effects. VAMS devices are calibrated to contain specified volumes of blood and exhibits minimal sample volume variation for samples containing different levels of hematocrit and does not suffer from inhomogeneity (Spooner et al, ; Qu et al, ). These devices are extremely useful for TK and PK studies using animals, as it reduces sample volume and number of animals, which follows the three “R's” guidelines of reduce, refine, and replace for in situ sampling to preserve animal health and welfare (Houbart et al, ).…”

Introductory Chapter: From Measuring Serotonin Neurotransmission to Evaluating Serotonin Post-Receptor Signaling Transduction

“…Ying Qu Leulan Bioscience, San Diego, California, USA *Address all correspondence to: yingqu68@gmail.com to absorb, distribute, metabolize, and excrete drug due to concurrent disease, age, concomitant medication or genetic abnormalities, the drug's steady-state concentration in the body may have a more than 20-fold interindividual variation when the same dose of drug is administrated [38,39]. TDM quantifies the drug's concentration in plasma or serum to adjust the dosage of individual patients, which increases probability of response and decreases risk of adverse drug reactions/ toxicity [40,41]. Moreover, TDM has the potential to enhance the cost-effectiveness of antidepressant therapy [42][43][44].…”