Capillary electromigration techniques coupled to mass spectrometry: Applications to food analysis

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

“…Therefore, many ion sources have been developed to achieve this transition. The most commonly used ionization technique for liquid samples is ESI [5–49]. The integrated two‐phase electroextraction (EE), CE, and MS combine rapid sample extraction to enable high‐performance separation and sensitive detection of metabolites (i.e., leucine, isoleucine, adenosine, phenylalanine, and guanosine).…”

“…Nowadays, it enables the analyses and separations of various s classes of analytes. CE provides advantages in terms of simplicity, short analysis times, high resolution and efficiency, and low reagent sample consumption [11][12][13]. The migration of analytes in CE results from a combination of electroosmotic and electrophoretic mobilities.…”

Foodomics: Analytical Opportunities and Challenges

“…It is expected that the evolution of targeted and untargeted approaches shall allow the suitable determination of a higher number of compounds in a short time, which is one of the main objectives in this field. 10,32 Foodomics is a recognized discipline to increase and ensure the standards of food safety, in which the application of highthroughput technologies such as genomics, transcriptomics, proteomics, and metabolomics constitutes the main tool to achieve such objectives. 75 As it is well-known, the evaluation of pathogens is one essential action line to ensure food safety, as well as to avoid the generation of food waste.…”

“…76 Apart from that, the evaluation of chemical contaminants has also a great importance, since there are numerous toxic substances commonly used in industry, agricultural, or medicine, among other areas, that can appear in food constituting an important risk for consumers, because of their toxicity, which increases with the development of a wide range of diseases. 10,77 A thorough revision of the most recent literature regarding the application of Foodomics in food safety shows that most of the applications developed in the last two years have been focused on the evaluation or the study of the influence of pathogens in food matrices. In this regard, different types of studies have been performed intended for the evaluation of the effect of specific pathogens on the spoilage of food matrices, 78,79 as well as the study of relevant markers during product storage, under certain conditions.…”

Potentiality of miniaturized techniques for the analysis of drugs of abuse

“…In principle, all stationary phases used in HPLC could be applied in CEC, however, there is a need: the particles or the monoliths must possess charged or chargeable groups for the generation of the EOF. Both techniques make use of detectors, such as UV or fluorescence, however they have also been successfully coupled with MS [10][11][12].…”