2004
DOI: 10.1002/anie.200490116
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Capillary Electrophoresis Analysis of DNA Adducts as Biomarkers for Carcinogenesis

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Cited by 21 publications
(40 citation statements)
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“…The ratios obtained were C : C : U : A : G = 1 : 6.6 : 4.3 : 6.9 : 2, roughly representing the composition of the oligonucleotide, except that the peak area for the pG conjugate was far too low. This is in line with results obtained with the BODIPY conjugates of 2'-deoxyguanosine-3' and 5'-monophosphate [5][6][7]9] arising from a quenching effect [16]. When the A m modified oligoribonucleotide was analyzed in the same way (data not shown) complete resolution of pA m and pC was not possible.…”
Section: Synthesis and Ce-lif Analyses Of Bodipy Conjugates Of Pnssupporting
confidence: 89%
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“…The ratios obtained were C : C : U : A : G = 1 : 6.6 : 4.3 : 6.9 : 2, roughly representing the composition of the oligonucleotide, except that the peak area for the pG conjugate was far too low. This is in line with results obtained with the BODIPY conjugates of 2'-deoxyguanosine-3' and 5'-monophosphate [5][6][7]9] arising from a quenching effect [16]. When the A m modified oligoribonucleotide was analyzed in the same way (data not shown) complete resolution of pA m and pC was not possible.…”
Section: Synthesis and Ce-lif Analyses Of Bodipy Conjugates Of Pnssupporting
confidence: 89%
“…The values show a similar sensitivity compared with the related analysis of DNA bases using the same method [5,6] with a LOD of the method for the analysis of RNA based on BODIPY conjugates of nucleoside-5'-monophosphates in the range from 80 to 200 pM determined by dilution of derivatized 10 mg samples of digested oligonucleotides. Likewise, correction factors were similar to those obtained by Wirtz et al [7,10] for 2'-deoxyribonucleoside-3'-monophosphates except for I.…”
Section: Validation Of the Analytical Methodsmentioning
confidence: 54%
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