Capillary electrophoresis in clinical and forensic analysis: Recent advances and breakthrough to routine applications

Thormann, Wolfgang; Wey, Anita B.; Lurie, Ira S.; Gerber, H; Byland, Christa; Malik, Naseem; Hochmeister, Manfred N.; Gehrig, Christian

doi:10.1002/(sici)1522-2683(19991001)20:15/16<3203::aid-elps3203>3.0.co;2-e

Cited by 70 publications

(48 citation statements)

References 195 publications

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“…Among forensic drugs, phenethyla-mines by far represent the most important group of compounds for which chiral analysis may be of crucial importance. Although already reported in the past decade (for reviews see [6,27,28]), the use of CD CE for the chiral separation of amphetamines and congeners still attracts the attention of several researchers.…”

Section: Forensic Drugs and Poisonsmentioning

confidence: 99%

Recent advances in the applications of CE to forensic sciences (2001–2004)

Tagliaro

Bortolotti

2006

Electrophoresis

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Recent advances in the applications of CE to forensic sciences (2001-2004)The present article reviews the applications of CE in forensic science covering the period from 2001 until the first part of 2005. The overview includes the most relevant examples of analytical applications of capillary electrophoretic and electrokinetic techniques in the following fields: (i) Forensic drugs and poisons, (ii) explosive analysis and gunshot residues, (iii) small ions of forensic interest, (iv) forensic DNA and RNA analysis, (v) proteins of forensic interest, and (vi) ink analysis.

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Section: Forensic Drugs and Poisonsmentioning

confidence: 99%

Recent advances in the applications of CE to forensic sciences (2001–2004)

Tagliaro

Bortolotti

2006

Electrophoresis

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“…Since the commercial availability of CE in the late 1980s, the CE applications have moved from the laboratory of analytical chemists to the laboratories of the clinical chemists [47,60,73,74]. CE is useful as clinical tool in the diagnosis and course of metabolic disorders such as phenylketonuria [75], homocystinuria or glutathione synthase deficiency [16] or porphyria [47].…”

Section: Pharmaceutical Clinical and Forensic Applicationsmentioning

confidence: 99%

“…CE is also a new powerful tool for the analysis of illicit/controlled drugs in biological samples [5,101]. At present, CE is applied on a routine basis in forensic laboratories, and it is used successfully in the screening procedures for toxicological or doping control [74,102]. Many drugs have been tested for these purposes in biological fluids as urine or plasma.…”

Section: Pharmaceutical Clinical and Forensic Applicationsmentioning

confidence: 99%

Biomedical applications of capillary electrophoresis with laser‐induced fluorescence detection

Páez

Hernández

2001

Biopharm & Drug Disp

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Capillary electrophoresis (CE) is a high-efficiency analytical technique that has had a great impact as a tool in biomedical research, clinical and forensic practice in the last ten years. Only in one of the applications, the DNA analysis, it has had an explosive exponential growth in the last few years. This impact is expressed in an enormous amount of CE articles and many reviews. The CE advantages with respect to other analytical techniques: the required very small sample volume, rapid analysis, great resolution power and low costs, have made this technique ideal for the analysis of a numerous endogenous and exogenous substances present in biological fluids. The different modes of CE have been coupled to different detection techniques such as UV-absorbance, electrochemical, mass spectrometry and laser-induced fluorescence detection (LIFD) to detect different nature and molecular size separated analytes. This review focuses mostly on the applications of CE-LIFD, to measure drugs and endogenous neuroactive substances such as amino acids and monoamines, especially in microdialysis samples from experimental animals and humans. CE-LIFD trends are discussed: automated faster analysis with capillary array systems, resolution power improvement, higher detection sensitivity, and CE systems miniaturization for extremely small sample volume, in order to make CE easier and affordable to the lab bench or the clinical bed.

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“…Les détecteurs vont du simple spectromètre ultraviolet au spectromètre de masse (SM et SM/SM), de façon à améliorer la sensibilité. Des revues entières sont consacrées à l'analyse des amphétamines par CE et une revue générale vient d'être publiée (68).…”

Section: Electrophorèse Capillaire (Ec)unclassified