Capillary Electrophoresis Micro X-ray Fluorescence:  A Tool for Benchtop Elemental Analysis

Tc, Miller; Mr, Joseph; Gj, Havrilla; Lewis, C.L.; Majidi,

doi:10.1021/ac0207269

Cited by 17 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The response patterns for alkaline earth metal ions in a system based on using such absorbing counter-ion could be predicted theoretically in terms of the Kohlrausch regulation function [153]. The only development of CE with X-ray fluorescent detection over the review period was the interfacing of a simple CE instrument with a bench top energy-dispersive micro-Xray fluorescence system [154]. However, the LODs remained of a magnitude similar to those attained with synchrotron X-ray fluorescence excitation (ca.…”

Section: Other Detection Techniquesmentioning

confidence: 99%

“…Recently developed CE techniques play an increasingly important role in discriminating the speciation pattern of a diversity of chemical forms of metals (chromium [79,83,94,95,105,232,233], including characterization of hydrolyzed Cr(III) species regarding the degree of oligomerization [234], iron [79,177,187,235,236], mercury [237,238], cobalt [154,189,190], vanadium [79,239], nickel [113,114], rhodium [240][241][242], rhenium [243]), metalloids (arsenic [78,104,146,180,211,244,245], with one of the best CE performance examples on the number of separated As species [211], selenium [88,102,104,118,147,[246][247][248], antimony [147], tellurium [104]), and nonmetals (nitrogen [156,…”

Section: Speciation Analysismentioning

confidence: 99%

See 1 more Smart Citation

Capillary electrophoresis of inorganic ions: An update

Timerbaev

2004

Electrophoresis

View full text Add to dashboard Cite

This review as a sequel of three earlier similar reports gives a summary of the progress and significant methodological developments, starting from 2002, in the use of capillary electrophoresis (CE) for inorganic ion analysis. As substantiated by the illustrative number of relevant references, improvements in sensitivity achieved both in and outside a CE system, advances in manipulating the separation selectivity, novel hardware configurations, and system performance innovations are continually being reported over the review period. Specifically viewed are the recent advancements in elemental (bio)speciation analysis, which remains one of the most fertile areas of CE research, as well as in three recently booming research topics: contactless conductivity detection, separations on microchips, and transient isotachophoretic preconcentration. A state-of-the-art picture of technique's potentialities within the field of interest presented here demonstrates that CE has become recognized and is growing in acceptance as a reliable alternative to traditional analytical methods such as high-performance liquid chromatography (HPLC).

show abstract

Section: Other Detection Techniquesmentioning

confidence: 99%

Section: Speciation Analysismentioning

confidence: 99%

Capillary electrophoresis of inorganic ions: An update

Timerbaev

2004

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…Non‐destructive on‐line elemental detection is feasible with X‐ray fluorescence spectrometry (XRF). Combined, CE‐XRF has the potential to both separate and detect elemental analytes that cannot be investigated with more conventional methods, allowing for both qualitative and quantitative evaluation of elemental speciation . Little has been done so far with respect to CE‐XRF.…”

Section: Introductionmentioning

confidence: 99%

CE‐XRF–initial steps toward a non‐invasive elemental sensitive detector for liquid separations

Tyssebotn

Fittschen

2017

Electrophoresis

View full text Add to dashboard Cite

The toxicity, bioavailability, and mobilization of elements within the biosphere is dependent on its species. CE has emerged as a strong separation technique for elemental speciation. Conventionally, CE has been coupled with UV-vis, C D, PIXE (proton-induced X-ray emission), and ICP-MS. UV-vis and C D are not elemental sensitive detection methods, PIXE requires the etching of the detection window resulting in a very brittle capillary, and ICP-MS is an expensive large footprint instrument. Here, we aim to develop an elemental specific detector, XRF (X-ray fluorescence spectrometry), for use with CE. A custom-built micro-XRF was tested and static LODs were determined for 19 elements (Ca-U) with both unmodified (20-926 ppm) and modified capillaries (20-291 ppm). A custom-built CE was combined with the micro-XRF and separation of Ca and Co was obtained. Sr coeluted with Ca in the mixture, but because of the elemental sensitivity of XRF, the Sr and Ca signals could be separated. After successful testing of the micro-XRF, the feasibility of using a low-cost X-ray source and detector was tested. Even lower LODs were obtained for Ga and Rb, showing the feasibility of a smaller, low-cost XRF unit as an elemental specific detector. However, the buffer selection that can be conveniently used with XRF is currently limited due to capillary corrosion, likely correlated to radiolysis.

show abstract

“…[2][3][4][5][6] Elemental analysis of low volume liquid samples by XRF has been demonstrated by interfacing a fused silica capillary electrophoresis apparatus with a bench top micro-XRF. [7] Scatter from the silica capillary limited sensitivity and detection limits were reported for Cu, Co, Fe, and Zn on the order of 20-150 ng/μl. The potential for quantitative analysis in a microchip by confocal 3D-XRF was assessed using a custom polyethylene terephthalate microchip, which contained two overlapping channels.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic sample preparation for elemental analysis in liquid samples using micro X‐ray fluorescence spectrometry

et al. 2014

Self Cite

View full text Add to dashboard Cite

The integration of microfluidic devices with micro X-ray fluorescence (micro-XRF) spectrometry offers a new approach for the direct characterization of liquid materials. A sample presentation method based on use of small volumes (<5 μl) of liquid contained in an XRF-compatible device has been developed. In this feasibility study, a prototype chip was constructed, and its suitability for XRF analysis of liquids was evaluated, along with that of a commercially produced microfluidic device. Each of the chips had an analytical chamber which contained approximately 1 μl of sample when the device was filled using a pipette. The performance of the chips was assessed using micro-XRF and high resolution monochromatic wavelength dispersive X-ray fluorescence, a method that provides highly selective and sensitive detection of actinides. The intended application of the device developed in this study is for measurement of Pu in spent nuclear fuel. Aqueous solutions and a synthetic spent fuel matrix were used to evaluate the devices. Sr, which has its Kα line energy close to the Pu Lα line at 14.2 keV, was utilized as a surrogate for Pu because of reduced handling risks. Between and within chip repeatability were studied, along with linearity of response and accuracy. The limit of detection for Sr determination in the chip is estimated at 5 ng/μl (ppm). This work demonstrates the applicability of microfluidic sample preparation to liquid characterization by XRF, and provides a basis for further development of this approach for elemental analysis within a range of sample types.

show abstract

Capillary Electrophoresis Micro X-ray Fluorescence: A Tool for Benchtop Elemental Analysis

Cited by 17 publications

References 16 publications

Capillary electrophoresis of inorganic ions: An update

Capillary electrophoresis of inorganic ions: An update

CE‐XRF–initial steps toward a non‐invasive elemental sensitive detector for liquid separations

Microfluidic sample preparation for elemental analysis in liquid samples using micro X‐ray fluorescence spectrometry

Contact Info

Product

Resources

About