Capillary Hemangioblastoma: An Immunohistochemical Study

Holt, Stephanie; Bruner, Janet M.

doi:10.1093/ajcp/86.4.423

Cited by 20 publications

(14 citation statements)

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“…Our immunohistochemical results are widely comparable with those of most human hemangioblastomas [7][8][9][10][11]14,20 and with the case diagnosed by the AFIP. 1 Despite many investigations, the histogenesis of the tumor and particularly the origin of the stromal cells is still uncertain.…”

supporting

confidence: 85%

“…2,9,10,14,20 Endothelial markers (FVIIIrag and Ulex europeus I lectin) have reacted only with endothelial cells. 8,9,20 Although occasional positivity of stromal cells has been found with some histiocytic markers (␣1-antitrypsin, ␣1-antichymotrypsin, and lysozyme), these findings did not support a histiocytic origin. 8,9 Occasional positivity of stromal cells for GFAP has been interpreted as the result of entrapment of surrounding nervous tissue and reactive astrocytes.…”

mentioning

confidence: 78%

“…8,9,20 Although occasional positivity of stromal cells has been found with some histiocytic markers (␣1-antitrypsin, ␣1-antichymotrypsin, and lysozyme), these findings did not support a histiocytic origin. 8,9 Occasional positivity of stromal cells for GFAP has been interpreted as the result of entrapment of surrounding nervous tissue and reactive astrocytes. [7][8][9] Altogether, these results have suggested that stromal cells were heterogeneous including locally derived, nonangiogenic cells.…”

mentioning

confidence: 78%

“…8,9 Occasional positivity of stromal cells for GFAP has been interpreted as the result of entrapment of surrounding nervous tissue and reactive astrocytes. [7][8][9] Altogether, these results have suggested that stromal cells were heterogeneous including locally derived, nonangiogenic cells. 9 A neuroendocrine component of hemangioblastomas has been suggested because 30% of stromal cells immunoreacted with synaptophysin and approximately 25% with antibodies against substance P and neuropeptide YY.…”

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confidence: 99%

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Intramedullary Hemangioblastoma in a Dog

Cantile¹

2003

Veterinary Pathology

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Abstract.A 6-year-old male Pointer dog was presented with a 4-week history of progressive hind-limb stiffness. Magnetic resonance imaging demonstrated a focal intramedullary lesion at T 1 level with a pattern of ring contrast enhancement. At necropsy, a circumscribed intramedullary reddish-gray tumor was observed. Microscopically, the tumor was composed of thin-walled capillaries lined by endothelial cells and separated by pleomorphic cells (stromal cells) with a moderate degree of anisokaryosis. Immunohistochemically, the endothelial cells were positive for factor VIII-related antigen and the stromal cells were positive for neuron-specific enolase and vimentin. GFAP-positive astrocytes were occasionally observed within the tumor. Both endothelial and stromal cells were negative for synaptophysin, S-100 protein, pankeratin, smooth muscle actin, CD34, CD68, ␣1-antichymotrypsin, and lysozyme. The tumor showed considerable morphologic and immunohistochemical similarities with human hemangioblastoma, and hence the inclusion of this tumor type within the primary neoplasms of the canine central nervous system is suggested.

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supporting

confidence: 85%

mentioning

confidence: 78%

mentioning

confidence: 78%

mentioning

confidence: 99%

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Intramedullary Hemangioblastoma in a Dog

Cantile¹

2003

Veterinary Pathology

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“…3,22), and vimentin (3,20,22,23). Positive immunoreactivity for S-100 protein is frequently but not always observed (2,(20)(21)(22)(24)(25)(26)(27)(28). Occasionally, positive results in stromal cells are reported for CD 57 (22), desmin (20,21), renin (27), keratin (27), synaptophysin (19), substance P (19), neuropepetide Y (19), transthyretin, and transferrin (29).…”

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confidence: 99%

Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell

Gläsker

Xia

et al. 2006

Cancer Research

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Hemangioblastomas are central nervous system (CNS) tumors of unknown histogenesis, which can occur sporadically or in von Hippel-Lindau disease. Hemangioblastomas are composed of neoplastic ''stromal'' cells of unknown origin, accompanied by intensive reactive angiogenesis. Failure to specify the cytologic origin of the stromal cell has precluded the development of nonsurgical therapies and limits understanding of its basic biology. We report that the stromal cells express proteins (Scl, brachyury, Csf-1R, Gata-1, Flk-1, and Tie-2) that characterize embryonic progenitor cells with hemangioblastic differentiation potential and conclude that embryonic progenitors with hemangioblast potential represent a possible cytologic equivalent of the stromal cell. We also identified a new autocrine/ paracrine stimulatory loop between the receptor Tie-2 and the hypoxia-inducible factor target Ang-1, which, combined with previous observations, suggests that a variety of autocrine loops may be initiated in hemangioblastomas, depending on the differentiation status of the tumor cells and the extent of HIF downstream activation. Finally, the consistent identification of Scl in the stromal cells may help explain the unique and characteristic topographical distribution of hemangioblastomas within the CNS. (Cancer Res 2006; 66(8): 4167-72)

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