THE DEVELOPNIENT of a circulatory system revolving a fluid moving under pressure exposes the organism to the mortal danger of losing this fluid. It is, therefore,, not surprising that a series of complex mechamsms has been evolved to protect it against such danger. These mechanisms we describe by the term haemostasis, the stopping of bleeding. They include:1 The coagulahon of blood or formatmu of fibrin. 2 The clumping of platelets or formation of a plug 8. The reaction and integrity of the blood vessel wall. Basic to the effectiveness of these mechanisms ~s blood flow, since on the one hand it brings materials necessary for haemostasis and on the other hand will wash away a partly or poorly formed block, so that we can list it aa the fourth factor or mechanism involved.