This chapter offers a comprehensive examination of the role multinational corporations played in shaping Latin America and the Caribbean during the first half of the 20th century. Against the backdrop of global economic and political tumult, the region emerged as an attractive destination for foreign investment, leading to the adoption of various economic models to facilitate capital influx. The analysis delves deep into the economic and political dynamics of the Americas during this era, tracing the enduring colonial legacies that influenced Latin American economies and exploring the impact of independence movements on foreign investment patterns. Furthermore, the chapter scrutinizes the emergence of multinational enterprises, classifying them into free-standing companies, holding companies, and joint ventures, and elucidates their profound influence on the region. It also investigates the ramifications of multinational corporations, encompassing financial manipulation, natural resource depletion, and political interference, shedding light on the erosion of regulatory capacity within Latin American nations. Ultimately, the chapter emphasizes the coercive nature of multinational influence, echoing historical colonial patterns of exploitation and setting the stage for ongoing challenges in the economic development of the region.