Capparis spinosa Alleviates DSS-Induced Ulcerative Colitis via Regulation of the Gut Microbiota and Oxidative Stress

Zhu, Xiaoting; Yang, Yi; Gao, Weizhen; Jiang, Bingjie; Shi, Lei

doi:10.1155/2021/1227876

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…Glucocapperin (methyl glucosinolate) is present above all in the buds and shoots and glucocleomine is present in the seeds and leaves. In the lipid fraction of the seeds, a high content of linoleic and oleic acid, sterols and tocopherols, aliphatic and triterpenic alcohol was detected [ 179 , 180 , 181 , 182 , 183 ].…”

Section: Resultsmentioning

confidence: 99%

Edible Halophytes and Halo-Tolerant Species in Apulia Region (Southeastern Italy): Biogeography, Traditional Food Use and Potential Sustainable Crops

Accogli

Tomaselli

Direnzo

et al. 2023

Plants

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The Mediterranean basin is rich in wild edible species which have been used for food and medicinal purposes by humans throughout the centuries. Many of these species can be found near coastal areas and usually grow under saline conditions, while others can adapt in various harsh conditions including high salinity. Many of these species have a long history of gathering from the wild as a source of food. The aim of this contribution is an overview on the most important halophyte species (Salicornia sp. pl., Arthrocaulon macrostachyum (Moric.) Piirainen & G. Kadereit, Soda inermis Fourr., Cakile maritima Scop., Crithmum maritimum L., Reichardia picroides (L.) Roth., Silene vulgaris (Moench) Garcke subsp. tenoreana (Colla) Soldano & F. Conti, Allium commutatum Guss., Beta vulgaris L. subsp. maritima (L.) Arcang., Capparis spinosa L.) that traditionally have been gathered by rural communities in southern Italy, with special interest on their ecology and distribution, traditional uses, medicinal properties, marketing and early attempts of cultivation. It is worth noting that these species have an attractive new cash crop for marsh marginal lands.

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Section: Resultsmentioning

confidence: 99%

Edible Halophytes and Halo-Tolerant Species in Apulia Region (Southeastern Italy): Biogeography, Traditional Food Use and Potential Sustainable Crops

Accogli

Tomaselli

Direnzo

et al. 2023

Plants

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“…Classified among medicinal plants, CS is used in the remedy of diverse illnesses due to the flavonoids, alkaloids, and phenolic acids it contains. Studies have shown that CS fruits contain p-Coumaric acid (5.53 ± 0.01 mg/100 g DW), Ferulic acid (0.73 ± 0.00 mg/100 g DW), Catechin (0.91 ± 0.02 mg/100 g DW), Epicatechin (1.14 ± 0.01 mg/100 g DW), Rutin (17.12 ± 0.00 mg/100 g DW), Kaempferol (3.44 ± 0.01 mg/100 g DW), and Quercetin They have reported that after seven days of treatment, the expression IL-6, IL-1β, and TNFα was suppressed, and improvement was achieved in mice by reducing oxidative stress (26). In another study, a streptozotocin-induced diabetes model was established in rats by Jalali et al (27) and diabetic rats were treated with water extracts from CS fruits for 28 days.…”

Section: Discussionmentioning

confidence: 99%

Capparis spinosa L. meyvelerinin metanol ekstraktının Parkinson hastalığının in-vitro deneysel modelinde nöroprotektif etkisi

Sezen

Yeşilyurt

Özkaraca

et al. 2022

Journal of Medicine and Palliative Care

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Aim: Parkinson’s disease (PD) is the second most widespread neurodegenerative disease. This study, it was aimed to investigate the effect of methanol extract obtained from Capparis spinosa L. fruits, which are known to have important bioactive components, on in-vitro experimental PD model. Material and Method: After collecting Capparis spinosa L. fruits from Alanya/Antalya, methanol extract was prepared by drying and grinding. SH-SY5Y cells grown in flasks were transferred to 96 well plates and were incubated until 80% cell density was reached. Different doses of methanol extract were applied to the cells 30 minutes before the PD model was formed. For the PD model, SH-SY5Y cells were exposed to 200 µM 6-OHDA for 24 hours. MTT analysis was performed to assess the viability of SH-SY5Y cells at the end of the 24-hour period. TOS, TAC, and IL-17A levels in the cell medium were determined using the ELISA method. Expression of TNFα and α-synuclein was defined using the immunohistochemical method. Results: Cell viability was found to be higher in all treatment groups than in the 6-OHDA group. Moderate levels of TNFα and α-synuclein positivity were observed in the 1500 µg/ml methanol extract group. It was determined that TOS and TAC levels change depending on the dose. It has been determined that the level of IL-17A decreases at low doses. Statistical significance was found between the groups. Conclusion: When the findings were examined, it was determined that the methanol extract obtained from Capparis spinosa L. fruits reduced oxidative stress and IL-17A levels at low doses and provided a neuroprotective effect by increasing the antioxidant capacity.

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“…Zhu et al [ 21 ] have reported that treatment with the aqueous C. spinosa fruit extract (200 and 400 mg/kg/day, for seven days) has anti-inflammatory effects in mice (n = 7) with ulcerative colitis, a chronic inflammatory disease. The tested extract reduced the expression of proinflammatory cytokines (TNF-α, IL-6, and IL-1β) and was found to have antioxidant properties.…”

Section: Biological Properties Of C Spinosamentioning

confidence: 99%

The Current State of Knowledge about the Biological Activity of Different Parts of Capers

Olas

2023

Nutrients

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The caper, from the Latin capra, meaning goat, is the common name for the salt-fermented floral buds of the perennial shrubs of the Capparis genus (Capparacea family). This genus is represented by about 250 species, including the very popular C. spinosa L. While the whole plant is edible, the aromatic floral buds are most widely consumed, being collected by hand prior to blooming, dried in the sun and pickled. Capers are usually served marinated in vinegar, brine or oil. They have a significant potential as dietary supplements due to their low calorie content and richness in bioactive phytochemicals. Numerous in vitro and in vivo studies have demonstrated that C. spinosa have various nutritional and biological properties, including antioxidant activity resulting from the presence of phenolic compounds. The present paper reviews the current literature concerning the biological properties of the fruits, buds, seeds, roots and leaves of C. spinosa, including their toxicity.

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Capparis spinosa Alleviates DSS-Induced Ulcerative Colitis via Regulation of the Gut Microbiota and Oxidative Stress

Cited by 9 publications

References 42 publications

Edible Halophytes and Halo-Tolerant Species in Apulia Region (Southeastern Italy): Biogeography, Traditional Food Use and Potential Sustainable Crops

Edible Halophytes and Halo-Tolerant Species in Apulia Region (Southeastern Italy): Biogeography, Traditional Food Use and Potential Sustainable Crops

Capparis spinosa L. meyvelerinin metanol ekstraktının Parkinson hastalığının in-vitro deneysel modelinde nöroprotektif etkisi

The Current State of Knowledge about the Biological Activity of Different Parts of Capers

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