Capsaicin: A Novel Approach to the Treatment of Functional Dyspepsia

Li, Tianxu; Yuan, Wei; Meng, Yaqi; Zhou, Qing; Li, Bin; Chen, Yijie

doi:10.1002/mnfr.202200793

Cited by 9 publications

(5 citation statements)

References 151 publications

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“…Capsaicin, a TRPV1 agonist, has an intense influence on thermoregulation, affecting only the warmsensitive side of the regulatory system [25]. Capsaicin is the main spicy component of red pepper [26]. It acts through the transient receptor potential vanilloid-1 (TRPV1) ion channel [27].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Increasing Bath Temperature on the Contractile Responses of the Large Gut in Adult and Neonate Rats

Singh,

Sharma,

Dixit

et al. 2023

Cureus

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IntroductionEarlier reports on the effect of temperature on gut motility concentrated on experiments conducted on the small intestines of adult animals. The effect of temperature on the large intestine, particularly in neonates, warrants further investigation. The current study investigated the effect of a temperature increase and its mechanism in the colon and rectum of neonate and adult rats. Methods and materialsIn an organ bath preparation, segments from the colon and rectum were subjected to increasing bath temperatures (37°C-40°C). In other groups, pretreatment with capsazepine (1 µM) and Nω-nitro-l-arginine methyl ester (L-NAME) (100 µM) was done, in different groups, to assess their impact on temperatureinduced contractile response. ResultsIncreasing the bath temperature significantly reduced the contractile tension in the colon and rectum. When L-NAME (100 µM)-pretreated segments of the colon and rectum were subjected to different bath temperatures, the contractile tension increased compared to the contractile tension at different bath temperatures without any drug. Capsazepine (1 µM) pretreatment, on the other hand, enhanced the decrease in the contractile tension in the colon and rectum of adult rats compared to the contractile tension produced at different bath temperatures without any drug, while in neonates, capsazepine (1 µM) pretreatment caused a rise in the contractile tension in the rectum with no effect in the colon. Increased bath temperature from 37°C to 40°C increased the contractile frequency in the colon and rectum in both adult and neonate rats. Pretreatment with L-NAME (100 µM) and capsazepine (1 µM) in adults and L-NAME (100 µM) in neonates caused an increase in the contractile frequency in both the colon and rectum; on the other hand, capsazepine pretreatment did not affect the contractile frequency in the colon and rectum of neonate rats compared to the contractile frequency produced at different bath temperatures without any drug. ConclusionThe contractile response of rats' large intestines, colon, and rectum to increasing temperatures may involve nitric oxide (NO)-mediated and transient receptor potential vanilloid-1 (TRPV1)-mediated mechanisms. The effects of capsazepine on the colon and rectum of adults and neonates differ, possibly due to the TRPV1mediated mechanism not developing properly in the neonate and developing later in adulthood.

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Section: Discussionmentioning

confidence: 99%

The Effect of Increasing Bath Temperature on the Contractile Responses of the Large Gut in Adult and Neonate Rats

Singh,

Sharma,

Dixit

et al. 2023

Cureus

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“…Various evidences suggest the established use of another polyphenol, capsaicin (CAP), as a phytochemical analgesic that works by binding with TRPV1, a nociceptive fibre ( 182 – 185 ). The vanillyl moiety of capsaicin is majorly responsible for its bioactivity and is used widely for the treatment of chronic musculoskeletal and neuropathic pain, chronic migraines and in treating functional dyspepsia ( 186 , 187 ). Capsaicin also shows an anti-inflammatory effect by down-regulating LPS-induced expression of COX-2 and NF-κB in RAW 264.7 macrophages ( 188 ).…”

Section: Bioactives and Osteoarthritis: Metabolic And Anti-inflammato...mentioning

confidence: 99%

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

Basak,

Hridayanka,

Duttaroy

2024

Front. Immunol.

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Bioactives significantly modify and maintain human health. Available data suggest that Bioactives might play a beneficial role in chronic inflammatory diseases. Although promised, defining their mechanisms and opting to weigh their benefits and limitations is imperative. Detailed mechanisms by which critical Bioactives, including probiotics and prebiotics such as dietary lipids (DHA, EPA, alpha LA), vitamin D, polysaccharides (fructooligosaccharide), polyphenols (curcumin, resveratrol, and capsaicin) potentially modulate inflammation and bone metabolism is limited. Certain dietary bioactive significantly impact the gut microbiota, immune system, and pain response via the gut-immune-bone axis. This narrative review highlights a recent update on mechanistic evidence that bioactive is demonstrated demonstrated to reduce osteoarthritis pathophysiology.

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“…Previous studies in animals and mammalian cell lines have not suggested any mutagenic effects of capsaicin in somatic cells or the germline (94). capsaicin cream has been used in the clinic for numerous years to relieve various types of pain, and long-term local application of capsaicin can be effective for treating skin cancer in mice (28,50,(95)(96)(97)(98).…”

Section: Pharmacokinetics Of Capsaicinmentioning

confidence: 99%

Pharmacological activity of capsaicin: Mechanisms and controversies (Review)

Zhang,

Fan

et al. 2024

Mol Med Rep

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Capsaicin, which is abundant in chili peppers, exerts antioxidative, antitumor, antiulcer and analgesic effects and it has demonstrated potential as a treatment for cardiovascular, gastrointestinal, oncological and dermatological conditions. Unique among natural irritants, capsaicin initially excites neurons but then ‘calms’ them into long-lasting non-responsiveness. Capsaicin can also promote weight loss, making it potentially useful for treating obesity. Several mechanisms have been proposed to explain the therapeutic effects of capsaicin, including antioxidation, analgesia and promotion of apoptosis. Some of the mechanisms are proposed to be mediated by the capsaicin receptor (transient receptor potential cation channel subfamily V member 1), but some are proposed to be independent of that receptor. The clinical usefulness of capsaicin is limited by its short half-life. The present review provided an overview of what is known about the therapeutic effects of capsaicin and the mechanisms involved and certain studies arguing against its clinical use were mentioned.

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Capsaicin: A Novel Approach to the Treatment of Functional Dyspepsia

Cited by 9 publications

References 151 publications

The Effect of Increasing Bath Temperature on the Contractile Responses of the Large Gut in Adult and Neonate Rats

The Effect of Increasing Bath Temperature on the Contractile Responses of the Large Gut in Adult and Neonate Rats

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

Pharmacological activity of capsaicin: Mechanisms and controversies (Review)

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