Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

Fattori, Victor; Hohmann, Miriam S. N.; Rossaneis, Ana C.; Pinho‐Ribeiro, Felipe A.; Verri, Waldiceu A.

doi:10.3390/molecules21070844

Cited by 365 publications

(288 citation statements)

References 278 publications

(386 reference statements)

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“…In turn, it facilitates migration of presynaptic vesicles which are released to synaptic cleft in exocytosis. It results in activation of postsynaptic membrane and generation of mediators which have proinflammatory properties such as CGRP (calcitonin gene related peptide) or P substance [24]. As it may seem, there is an internal contradiction.…”

Section: Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Health-promoting properties of compounds derived from Capsicum sp. A review

Szydełko

Boguszewska-Czubara

2017

Herba Polonica

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S u m m a r yThis article presents multidirectional effects of capsaicin and its natural derivatives as well as natural and synthetic analogs in term of their therapeutic properties. Active agents present in various Capsicum genus plants exert analgesic, anti-inflammatory, antibacterial, antioxidant and gastroprotective effects. Furthermore, capsaicin positively influences the metabolism of lipids. Numerous research show that capsaicinoids inhibit proliferation and migration process of cancer cells, what makes them molecules of high interest in oncology. Among broad range of positive activities, we have focused only on those properties that have already found application in medicine or seemed to be the most probably used in the near future. Even if in low or single doses this compound has been reported successful in numerous therapies, the negative consequences of high doses or prolonged administration is also discussed in the review.

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Section: Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Health-promoting properties of compounds derived from Capsicum sp. A review

Szydełko

Boguszewska-Czubara

2017

Herba Polonica

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“…These compounds typically make up 80-90% of the total capsaicinoid content in the capsicum fruits [9]. Capsaicin was also reported to exhibits the effect of mammalian vanilloid receptor subtype 1 (TRPV1) on insect behavioral thermoregulation.…”

Section: H943mentioning

confidence: 99%

FRACTION AND DETERMINATION OF CAPSAICINOIDS FROM RED PEPPER FRUITS WITH INSECTICIDAL ACTIVITY AGAINST MEALWORM, Tenebrio molitor, AND SUPERWORM, Zophobas morio

Ngo¹

2018

JST

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Green chemistry has recently been an active area of research and it is expected to replace the chemical synthesis in agriculture. In this study, our attempt is to fractionate and determine the capsaicinoids from red pepper fruit to control mealworm Tenebrio molitor and superworm Zophobas morio. The methanol extraction of red pepper fruit (Capsicum annuum L.) effectively killed T. molitor and Z. morio at the concentration of 10000 ppm. The insecticidal activity of nhexane, dichloromethane and aqueous layers derived from the extract by liquid-liquid partitioning were evaluated. Among them, only dichloromethane layer showed insecticidal activity; whereas n-hexane and aqueous layers were inactive against tested pests. The dichloromethane layer was successively fractionated by silica gel column chromatography to afford insecticidal compounds. The chemical structures of active compounds in dichloromethane layer were elucidated by the analysis of NMR and MS spectroscopic data. The active compounds were determined to be as capsaicinoids and their insecticidal activity was also evaluated using the in vitro residual contact bioassay method. The extracts containing capsaicinoids were formulated into a suspension concentrate (SC) biopesticide and evaluated for efficacy against T. molitor and Z. morio. The biopesticide caused mortalities by 95-100 % against tested pests at 1000 µg/mL. The study results suggested that extracts containing capsaicinoids could be used as active ingredients for the preparation of the biopesticide to control insect pests thereby preserving stored products in sustainable agriculture.

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“…Capsaicin and other TRPV1 agonists selectively stimulate nociceptive neurons, and thus while it induces pain, it is possible to treat pain by boosting analgesic pathways [91]. In this regard the use of the TRPV1 agonist, resiniferatoxin (RTX), to block cancer pain has recently been reviewed [92].…”

Section: Trpv1 Receptorsmentioning

confidence: 99%

Osteosarcomagenesis: Biology, Development, Metastasis, and Mechanisms of Pain

Smeester¹,

Moriarity²,

Beitz³

2017

Osteosarcoma - Biology, Behavior and Mechanisms

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Osteosarcoma is the most common primary cancer of the bone and third most common cancer in children and adolescents with approximately 900 new cases annually in the United States. A major facet of osteosarcoma is its high level of genomic instability, in particular chromosomal instability, which is the result of increased or decreased chromosome number in a cell. Furthermore, pain is the most common symptomatic feature of osteosarcoma that lacks efective therapy. Pain in osteosarcoma is relatively more complicated than many other painful conditions requiring a more thorough understanding of its etiology, pathobiology, and neurobiology to allow the development of beter therapies for reducing pain in osteosarcoma patients. Studies are underway to deine the diverse modalities of presentation, growth, development, metastases, and nociception in osteosarcoma. New data from human studies in combination with data from studies incorporating transgenic mouse models of osteosarcoma are providing valuable insights into the mechanisms underlying the development of both the tumor and the tumor-induced pain. These new data will undoubtedly lead to improved prognoses, as well as the development of novel therapeutics that will signiicantly decrease bone cancer pain.

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Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

Cited by 365 publications

References 278 publications

Health-promoting properties of compounds derived from Capsicum sp. A review

Health-promoting properties of compounds derived from Capsicum sp. A review

FRACTION AND DETERMINATION OF CAPSAICINOIDS FROM RED PEPPER FRUITS WITH INSECTICIDAL ACTIVITY AGAINST MEALWORM, Tenebrio molitor, AND SUPERWORM, Zophobas morio

Osteosarcomagenesis: Biology, Development, Metastasis, and Mechanisms of Pain

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