Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test

Debreceni, András; Abdel-Salam, Omar M.E.; Figler, Mária; Juricskay, I.; Szolcsányi, Janós; Mózsik, Gyula

doi:10.1016/s0928-4257(99)00114-x

Cited by 45 publications

(42 citation statements)

References 40 publications

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“…Because the rate of gastric emptying directly impacts nutrient uptake, facilitating gastric motility by pharmacologic agents could have a positive impact on satiety. Indeed, there is good evidence that capsaicin can increase the rate of gastric motility in humans (Gonzalez et al, 1998;Debreceni et al, 1999). This also implies a therapeutic potential for TRPV1 agonists in the pharmacotherapy of gastroparesis (Barquist et al, 1996).…”

Section: E Transient Receptor Potential Channels In Obesity and Metamentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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Section: E Transient Receptor Potential Channels In Obesity and Metamentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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“…The primary goals of ileostomy care are to prevent excreta that are excessive, loose and watery, odoriferous, and contain recognizable food particles (Bingham et al 1982). For these reasons, spices are routinely excluded from patients' diets (United Pasia 2011) because they-red peppers specifically-are purported to increase the rate of gastric emptying and small intestinal motility (Gonzalez et al 1998;Debreceni et al 1999). However, blanket recommendations to exclude spices in the diet of all patients with ileostomies may be unwarranted for a number of reasons.…”

Section: Ulcerative Colitismentioning

confidence: 99%

Chemosensory Properties of Pungent Spices: Their Role in Altering Nutrient Intake

2015

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Background The general population is not compliant with national dietary recommendations for promoting health and reducing chronic disease risk. While rising obesity rates suggest that the majority of the population is overconsuming, many individuals affected with either acute or chronic diseases struggle to maintain adequate dietary intake and are at high nutritional risk. Flavor is the primary driver of food intake; however, disliked flavors are a major barrier to consumer adherence with dietary recommendations for both groups. Spices that contribute to chemical burn-such as black pepper, garlic, ginger, mustard, oregano, red pepper, and wasabi-alter food flavors. Purpose This paper explores the role of these pungent spices in altering nutrient intake across the lifespan. The role of chemical burn in manipulating dietary intake in both diseased and healthy populations is discussed. Application Implications for using pungent spices to enhance compliance with dietary manipulations are described. Proposed functions of pungent spices are maintaining, preserving, and enhancing flavor to offset the reductions in liking and palatability that are associated with dietary modifications and disease status.

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“…Various human and animal model studies indicate that stomach motility can be stimulated by capsaicin (from the chilli pepper Capsicum annuum), 68 as well as Vernonia amygdalina leaf extracts, 69 the mixed-extract herbal formulation known as Iberogast (also known as STW 5) which includes components such as Citrus limonum, Glycyrrhiza glabra, Mentha piperita and Matricaria recutita, 70 and ginger (Zingiber officinale) extracts, 71 while diarrhoea can be caused by Cassia angustifolia (senna) extract. 72 Furthermore, a common use for Aloe vera is as a laxative.…”

Section: Interactions Affecting Drug Absorptionmentioning

confidence: 99%

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

Cock¹

2014

Phcog Commn.

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Background: Plants have been used therapeutically for thousands of years and continue to be the main treatment modality for a large percentage of the world's population. Furthermore, herbal medicine usage is increasing in Western countries as complementary (and sometimes alternative) treatments in conjunction with allopathic medicine. At the same time, the usage of allopathic medicines is being increasingly incorporated into the medicinal systems of developing countries, often resulting in the concurrent usage of both systems. Importance of the Study: Despite the widespread usage in developing countries and the trend of increasing medicinal plant usage in Western countries, herbal medicines remain understudied and there are misunderstandings amongst users and practitioners about the safe usage of these medications, particularly when used in conjunction with other medicines. Herbal medicines are generally not held to the same rigorous standards as allopathic medicines. There is usually a lack of industry regulation and manufacturing standards and guidelines, resulting in inferior (or unsafe) medicines being sold to consumers. Similarly, there is a lack of understanding amongst many medical practitioners of both traditional and allopathic medicine systems of how drugs from the two systems can be safely used together. Aim: The aim of this review is to summarise the current knowledge about herbal medicines and how they can be used safely, with the aim of not only highlighting some of the unsafe uses, but also to stimulate further research. I have also aimed to highlight the need for greater regulation and standardisation of herbal medicines.

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Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test

Cited by 45 publications

References 40 publications

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Chemosensory Properties of Pungent Spices: Their Role in Altering Nutrient Intake

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

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