Capsaicin, its clinical significance in patients with painful diabetic neuropathy

Dludla, Phiwayinkosi V.; Nkambule, Bongani B.; Cirilli, Ilenia; Marcheggiani, Fabio; Mabhida, Sihle E.; Ziqubu, Khanyisani; Ntamo, Yonela; Jack, Babalwa; Nyambuya, Tawanda M.; Hanser, Sidney; Mazibuko-Mbeje, Sithandiwe E.

doi:10.1016/j.biopha.2022.113439

Cited by 25 publications

(13 citation statements)

References 96 publications

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“…Topical capsaicin 0.075% cream, applied to the painful areas for approximately 8 weeks, has been shown to reduce pain, which may lead to clinical improvements in walking, working, and sleeping in patients with PDPN. 62 In a randomized, placebo-controlled study, capsaicin 8% patch has been shown to be effective in relieving pain up to 24 weeks after application. 63 It has also been shown to provide pain relief in a disease-modifying manner via nerve regeneration and restoration of function in PDPN.…”

Section: Symptomatic Pain Treatmentmentioning

confidence: 99%

4. Painful diabetic polyneuropathy

Zuidema,

de Galan,

Brouwer

et al. 2023

Pain Practice

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IntroductionPain as a symptom of diabetic polyneuropathy (DPN) significantly lowers quality of life, increases mortality and is the main reason for patients with diabetes to seek medical attention. The number of people suffering from painful diabetic polyneuropathy (PDPN) has increased significantly over the past decades.MethodsThe literature on the diagnosis and treatment of diabetic polyneuropathy was retrieved and summarized.ResultsThe etiology of PDPN is complex, with primary damage to peripheral nociceptors and altered spinal and supra‐spinal modulation. To achieve better patient outcomes, the mode of diagnosis and treatment of PDPN evolves toward more precise pain‐phenotyping and genotyping based on patient‐specific characteristics, new diagnostic tools, and prior response to pharmacological treatments. According to the Toronto Diabetic Neuropathy Expert Group, a presumptive diagnosis of “probable PDPN” is sufficient to initiate treatment. Proper control of plasma glucose levels, and prevention of risk factors are essential in the treatment of PDPN. Mechanism‐based pharmacological treatment should be initiated as early as possible. If symptomatic pharmacologic treatment fails, spinal cord stimulation (SCS) should be considered. In isolated cases, where symptomatic pharmacologic treatment and SCS are unsuccessful or cannot be used, sympathetic lumbar chain neurolysis and/or radiofrequency ablation (SLCN/SLCRF), dorsal root ganglion stimulation (DRGs) or posterior tibial nerve stimulation (PTNS) may be considered. However, it is recommended that these treatments be applied only in a study setting in a center of expertise.ConclusionsThe diagnosis of PDPN evolves toward pheno‐and genotyping and treatment should be mechanism‐based.

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Section: Symptomatic Pain Treatmentmentioning

confidence: 99%

4. Painful diabetic polyneuropathy

Zuidema,

de Galan,

Brouwer

et al. 2023

Pain Practice

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“…Interestingly, capsaicin can also induce analgesia. In fact, the topical application of capsaicin has been used for the treatment of localized pain ( Deal et al, 1991 ; Hersh et al, 1994 ; Gratton and Cusson, 1995 ; Winocur et al, 2000 ; Melis et al, 2019 ), and the use of capsaicin as a therapeutic approach for diabetic patients with symptoms of painful neuropathy has been recently reviewed by Dludla et al (2022) . It is well accepted that repeated exposure to capsaicin induces a calcium-mediated desensitization of TRPV1 channels ( Jancsó et al, 1967 ; Hains et al, 2003 ).…”

Section: The Therapeutic Potential Of Na V Cha...mentioning

confidence: 99%

Voltage-gated sodium channels in diabetic sensory neuropathy: Function, modulation, and therapeutic potential

Bigsby

Neapetung

Campanucci

2022

Front. Cell. Neurosci.

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Voltage-gated sodium channels (NaV) are the main contributors to action potential generation and essential players in establishing neuronal excitability. NaV channels have been widely studied in pain pathologies, including those that develop during diabetes. Diabetic sensory neuropathy (DSN) is one of the most common complications of the disease. DSN is the result of sensory nerve damage by the hyperglycemic state, resulting in a number of debilitating symptoms that have a significant negative impact in the quality of life of diabetic patients. Among those symptoms are tingling and numbness of hands and feet, as well as exacerbated pain responses to noxious and non-noxious stimuli. DSN is also a major contributor to the development of diabetic foot, which may lead to lower limb amputations in long-term diabetic patients. Unfortunately, current treatments fail to reverse or successfully manage DSN. In the current review we provide an updated report on NaV channels including structure/function and contribution to DSN. Furthermore, we summarize current research on the therapeutic potential of targeting NaV channels in pain pathologies, including DSN.

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“…The combination of vitamin K with these traditional and modern therapies may have a greater effect on wound healing, which also gives us an idea to develop a new drug in the future. In addition, the different bioavailability, therapeutic dose and duration of drugs may also have a great impact on the therapeutic effect (Dludla et al, 2022). Relevant studies have shown that MK7, a subtype of vitamin K2, is the most effective in terms of bioavailability and biological effects (Cirilli et al, 2020;Cirilli et al, 2022).…”

Section: Figurementioning

confidence: 99%

Effect of vitamin K on wound healing: A systematic review and meta-analysis based on preclinical studies

Tang

Ruan

et al. 2022

Front. Pharmacol.

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Background: In recent years, many studies have found that vitamin K is beneficial to wound healing. However, some research results seem to be in conflict. The purpose of this study was to evaluate the effect of vitamin K on wound healing.Methods: We systematically and comprehensively searched the PubMed, Web of Science, Embase, Cochrane library, China National Knowledge Infrastructure (CNKI), VIP and Wanfang eletronic databases. We applied revman5.3 software to calculate the weighted mean difference (WMD) of 95% confidence interval (CI) of animal and cell groups to evaluate the effect of vitamin K on wound healing. Two researchers independently selected studies and used the Cochrane Collaboration tool to assess the risk of bias in the included studies. The overall quality of evidence was assessed using the Recommendation, Assessment, Development and Evaluation (GRADE) working group approch.Results: Among the 1081 articles searched, 6 articles (16 studies in total) met the inclusion criteria. The results of quantitative analysis showed that vitamin K was beneficial to increase the wound healing rate in animal models [rat model: WMD = 27.45 (95% CI: 13.46, 41.44); p = 0.0001], but the opposite result was obtained in cell experiments [WMD = −33.84 (95% CI: −56.90, −10.79); p = 0.004].Conclusion: This meta-analysis hits that vitamin K could affect the process of wound healing, especially in animal models. While we could not know the clear role at present, which requires larger scale research. In addition, the concentration and safe dose of vitamin K also deserve further study.

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Capsaicin, its clinical significance in patients with painful diabetic neuropathy

Cited by 25 publications

References 96 publications

4. Painful diabetic polyneuropathy

4. Painful diabetic polyneuropathy

Voltage-gated sodium channels in diabetic sensory neuropathy: Function, modulation, and therapeutic potential

Effect of vitamin K on wound healing: A systematic review and meta-analysis based on preclinical studies

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