Capsaicin: Plants of the Genus <b><i>Capsicum</i></b> and Positive Effect of Oriental Spice on Skin Health

Abstract

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in &lt;i&gt;Capsicum&lt;/i&gt; fruits. &lt;b&gt;&lt;i&gt;Summary:&lt;/i&gt;&lt;/b&gt; Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. &lt;b&gt;&lt;i&gt;Key Messages:&lt;/i&gt;&lt;/b&gt; Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome.

Botanical Briefs: Handling the Heat From Capsicum Peppers

“…Capsaicin (8-methyl-6-nonanoyl vanillylamide) is a nonpolar phenol, which is why washing skin that has come in contact with capsaicin with water or vinegar alone is insufficient to solubilize it. 13 Capsaicin binds to the transient receptor potential vanilloid 1 (TRPV1), a calcium channel on neurons that opens in response to heat. When bound, the channel opens at a lower temperature threshold and depolarizes nerve endings, leading to vasodilation and activation of sensory nerves.…”

Nutritional Aspects of Vegetable Oils: Refined or Unrefined?

“…Reduction in the production of osteoblasts or increase in the incidence of osteoclasts is considered to be the main cause of osteoporosis. [57] Olive oil can also be beneficial in the prevention of osteoporosis. Oleuropein has an inhibitory effect against bone loss that occurs as a result of aging.…”

“…Reduction in the production of osteoblasts or increase in the incidence of osteoclasts is considered to be the main cause of osteoporosis. [ 57 ]…”

“…This compound can strengthen bone health through bone marrow stem cells, through which the formation of osteoblasts increases; also, it can reduce the development of adipose or fat cells. [ 57 ] It was shown that phenolic compounds in EVOO can stimulate the proliferation of osteoblast cells, which results in the reduced chances of bone‐related fractures. Polyphenols of EVOO can stimulate the proliferation of osteoblasts, modify their antigen profile, and promote alkaline‐phosphatase synthesis.…”

Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging

“…[31][32][33] On the contrary, elevated expression of TRPV1 is associated with atopic dermatitis in mice, and TRPV1 antagonists suppress dermatitis by inhibition of TRPV1 activation. 20,34 Basharat et al 35 showed that TRPV1 is essential for the reduction of ROS production and oxidative stress, pain sensation and inflammation, so TRPV1 has many health benefits. It was also suggested that, whenever TRPV1 is activated, it induces a second message through calcium influx in epidermal keratinocytes.…”