Capsaicin treatment of idiopathic rhinitis: The new panacea?

Rijswijk, Jeroen B. van; Wijk, Roy Gerth van

doi:10.1007/s11882-006-0051-2

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…Here, we use capsaicin to elucidate toxicological phenomena associated with TRPV1 activation in lung cells. Capsaicin is used clinically to induce cough (Morice et al, 2001) and to treat rhinitis (van Rijswijk and Gerth van Wijk, 2006). However, numerous case reports have described adverse respiratory effects and death in humans following exposures to concentrated capsaicinoid aerosols (Heck, 1995;Steffee et al, 1995;Billmire et al, 1996).…”

Section: N-(4-tert-butylbentyl)-nј-[3-fluoro-4-(methylsulfonylamino)bmentioning

confidence: 99%

Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells

Thomas

Sabnis

Johansen

et al. 2007

J Pharmacol Exp Ther

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Transient receptor potential vanilloid 1 (TRPV1) is a calciumselective ion channel expressed in human lung cells. We show that activation of the intracellular subpopulation of TRPV1 causes endoplasmic reticulum (ER) stress and cell death in human bronchial epithelial and alveolar cells. TRPV1 agonist (nonivamide) treatment caused calcium release from the ER and altered the transcription of growth arrest-and DNA damage-inducible transcript 3 (GADD153), GADD45␣, GRP78/BiP, ATF3, CCND1, and CCNG2) in a manner comparable with prototypical ER stress-inducing agents. The TRPV1 antagonist -328) inhibited mRNA responses and cytotoxicity. EGTA and ruthenium red inhibited cell surface TRPV1 activity, but they did not prevent ER stress gene responses or cytotoxicity. Cytotoxicity paralleled eukaryotic translation initiation factor 2, subunit 1 (EIF2␣) phosphorylation and the induction of GADD153 mRNA and protein. Transient overexpression of GADD153 caused cell death independent of agonist treatment, and cells selected for stable overexpression of a GADD153 dominant-negative mutant exhibited reduced sensitivity. Salubrinal, an inhibitor of ER stress-induced cytotoxicity via the EIF2␣K3/EIF2␣ pathway, or stable overexpression of the EIF2␣-S52A dominant-negative mutant also inhibited cell death. Treatment of the TRPV1-null human embryonic kidney 293 cell line with TRPV1 agonists did not initiate ER stress responses. Likewise, n-benzylnonanamide, an inactive analog of nonivamide, failed to cause ER calcium release, an increase in GADD153 expression, and cytotoxicity. We conclude that activation of ER-bound TRPV1 and stimulation of GADD153 expression via the EIF2␣K3/EIF2␣ pathway represents a common mechanism for cytotoxicity by cell-permeable TRPV1 agonists. These findings are significant within the context of lung inflammatory diseases where elevated concentrations of endogenous TRPV1 agonists are probably produced in sufficient quantities to cause TRPV1 activation and lung cell death.

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Section: N-(4-tert-butylbentyl)-nј-[3-fluoro-4-(methylsulfonylamino)bmentioning

confidence: 99%

Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells

Thomas

Sabnis

Johansen

et al. 2007

J Pharmacol Exp Ther

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“…The NANIPER patients are also highly sensitive and a response can be provoked with cold dry air that has similarities to skier's nose in AR patients in the Alps. Complete desensitization with capsaisin is effective treatment for at least 1 year . It would be interesting to study ASIC3 expression in the nasal mucosa of NANIPER patients.…”

Section: Asics In Respiratory Tractmentioning

confidence: 99%

Acid‐sensing ion channels in allergic rhinitis

KleinJan

2012

Clin Experimental Allergy

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“…verificado por meio da história clínica, do teste alérgico e do exame citológico nasal (Van Rijswijk et al, 2005;Van Rijswijk et al, 2006).…”

Section: Introdução⎪3unclassified

Distribuição de colágeno na concha nasal inferior de pacientes com rinite alérgica ou idiopática

Salgado¹

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Ao Dr. Olavo de Godoy Mion, por todo auxílio oferecido no Grupo de Rinite e por todos os ensinamentos. Ao Dr. Marcelo Alves Ferreira, pela grande ajuda na análise estatística e na redação deste trabalho. À Dra. Nilsa Regina Damaceno-Rodrigues, pelo auxílio com as lâminas e análise microscópica. v Ao Thiago Carvalho, pela amizade e companheirismo que se iniciou durante a pós-graduação. A todos do Laboratório de Biologia Celular (LIM 59), Valéria, Gisele, Gildásio, Íris, Cláudia, Elnara, Adão, Miriam, Cecília, Margarida e Ângela, que tanto contribuíram e me auxiliaram nesse trabalho. À Marilede, Marcia, Luci e Adílson, pelo apoio de extrema importância.

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Capsaicin treatment of idiopathic rhinitis: The new panacea?

Cited by 5 publications

References 48 publications

Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells

Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells

Acid‐sensing ion channels in allergic rhinitis

Distribuição de colágeno na concha nasal inferior de pacientes com rinite alérgica ou idiopática

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