Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet

Wikan, Naruemon; Tocharus, Jiraporn; Sivasinprasasn, Sivanan; Kongkaew, Aphisek; Chaichompoo, Waraluck; Suksamrarn, Apichart; Tocharus, Chainarong

doi:10.1016/j.jphs.2020.03.008

Cited by 12 publications

(10 citation statements)

References 46 publications

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“…Our previous study demonstrated that PAVA could improve hepatic OxS, which leads to apoptosis and metabolic dysfunction in HFD‐fed rats. [ 27 ] OxS is the predominant inducer of NAFLD progression, triggering advanced liver pathology and progression toward NASH through inflammatory and fibrogenesis cascades. [ 14,36 ] TLR4 has been implicated in the pathogenesis of NASH because of its association with FA‐triggered inflammatory activation, which results in the activation of NF‐κB and production of pro‐inflammatory cytokines and/or anti‐inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…The rats were given a normal diet for 1 week as an acclimatization period, and then fed with a normal diet (19.77% of energy from fat) (normal-chow-diet [NCD]; n = 6) or HFD (65.26% of energy from fat) (HFD; n = 18) for 16 weeks. [5,27,28] The composition of the HFD was estimated by the Nutrition Survey program from the nutrition division of the Department of Health (Ministry of Public health). After that, the HFD rats were randomly divided into three groups (n = 6 each); HFD, HFD plus PAVA (H + PAVA) at the dose of 1 mg/kg/day (Nonivamide, purity ≥ 96%; Santa Cruz Biotechnology) were dissolved in 10% Tween 80 and 10% ethanol in 0.9% normal saline solution) via subcutaneous injection, [29] HFD plus RSV (H + RSV).…”

Section: Hfd-induced Nafld Ratsmentioning

confidence: 99%

“…Our previous study reported the potential effects of the capsaicinoid nonivamide (PAVA) in improving hepatic architecture organization in high‐fat diet (HFD)‐induced rats, reducing intrahepatic lipid storage, and maintaining liver function, including oxidative stress (OxS) and apoptosis. [ 27 ] However, the mechanism of PAVA in NAFLD and related abnormalities requires further exploration to determine its role in slowing progressive NASH and fibrogenesis. Rosuvastatin (RSV) is well‐known as an β‐hydroxy β‐methylglutaryl‐CoA (HMG‐CoA) reductase inhibitor and is commonly used in certain patients with high lipid profiles and CVD.…”

Section: Introductionmentioning

confidence: 99%

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The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model

Wikan

Tocharus

Oka

et al. 2022

J Biochem & Molecular Tox

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Nonalcoholic fatty liver disease (NAFLD) is relatively associated with comorbidities in obesity and metabolic inflammation. Low-grade inflammation following the highfat diet (HFD)-induced NAFLD can promote the development of nonalcoholic steatohepatitis (NASH) through particularly liver-resident immune cell recruitment and hepatic nuclear factor kappa B (NF-κB) pathway. Therefore, inflammatory intervention may contribute to NASH reduction. Pelargonic acid vanillylamide (PAVA) or nonivamide is one of the pungent capsaicinoids of Capsicum species and has been found in chili peppers. Our previous study demonstrated that PAVA improved hepatic function, decreased oxidative stress and reduced apoptotic cell death but the insight role of PAVA on NAFLD is still unclear. Thus, this study aimed to investigate the underlying anti-inflammatory mechanism of PAVA in an NAFLDrat model. Male Sprague Dawley rats were fed with normal diet or HFD for 16 weeks. Then high-fat rats were given vehicle or PAVA (1 mg/kg/day) for another 4 weeks. We found that PAVA alleviated hepatic inflammation associated with the reducing toll-like receptor 4/NF-κB pathway, showing significantly lower recruitment of cluster of differentiation 44. PAVA also maintained activity of insulin signaling pathway, and attenuated NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome formation. NAFLD progresses to NASH through transforming growth factor (TGF-β1), and also recovery to simple stage followed by PAVA suppresses pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway. Therefore, our findings suggest that

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Section: Discussionmentioning

confidence: 99%

Section: Hfd-induced Nafld Ratsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model

Wikan

Tocharus

Oka

et al. 2022

J Biochem & Molecular Tox

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“…The liver coefficient was the highest ( p ≤ .05) in animals fed a hypercholesterolemic diet compared with a group (G1). This increment may be attributed to an increase in the liver weight to the accumulation of fat and cholesterol (fatty liver) inside the liver tissues of rats fed a high‐fat diet (Wikan et al, 2020). The liver hypertrophy was remarkable in G2, RDF, and WDF but less evident in RB and WB.…”

Section: Resultsmentioning

confidence: 99%

The ability of yoghurt supplemented with dietary fibers or brans extracted from wheat or rice to reduce serum lipids and enhance liver function in male hypercholesterolemic rats

Dabour

El-Saadany

Shoukry

et al. 2022

Journal of Food Biochemistry

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This study was undertaken to evaluate the effect of yoghurt supplementation with rice and wheat brans or dietary fibers on serum lipid profile, liver, and heart functionalities, and hepatopathological aspects of the liver of hypercholesterolemic rats. 48 male rats were divided into 8 groups. Group 1 was kept as negative control and fed with a standard diet, and groups 2 to 6 were fed a hypercholesterolemia‐induced diet supplemented with brans or dietary fibers of both grains. G2 received yoghurt without supplementation. The experiment lasted for 4 weeks. Results revealed that hypercholesterolemic rats administrated yoghurt supplemented with brans or dietary fibers reduced serum glucose from 113.9 ± 2.72 to 85.5 ± 4.94 in the serum of animals that received dietary fibers of rice and wheat, respectively. In addition, lipids profile and liver antioxidant status were improved. In addition, liver and heart functionalities and liver histopathological architecture were all improved depending on the type of administrated brans or fibers added to yoghurt. The inclusion of 0.5% of rice or wheat brans could be recommended to be added to yoghurt. Practical applications Yoghurt is the most famous fermented milk in the world. Supplementation of yoghurt with rice and wheat brans or dietary fibers increased its nutritional value. We proved that this new product contributes to reducing serum glucose, improving lipids profile, and enhancing liver and heart functions in hypercholesterolemic rats. This study confirmed the suitability to add a thesis type of brans or dietary fibers as bioactive ingredients to yoghurt and increased the varieties of functional foods.

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“…Hence, a percentage of PC and BC would reach the colon and nowadays it is clear the two-way interaction between BC and individuals' gut microbiota can determine the health effects of BC through their biotransformation by gut microbiota (Espín, González-Sarrías, & Tomás-Barberán, 2017). In support of this notion, Wikan et al (2020) concluded that capsaicinoid nonivamide, the metabolite produced by gut microbiota from capsaicin, has effects on nonalcoholic fatty liver disease by reducing glucose insulin resistance and fat deposition through the promotion of the insulin signaling pathway stimulating GLUT2 translocation to the membrane.…”

Section: Introductionmentioning

confidence: 96%

Study of the impact of a dynamic in vitro model of the colon (TIM-2) in the phenolic composition of two Mexican sauces

Cárdenas-Castro

Venema

Sarriá

et al. 2021

Food Research International

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Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet

Cited by 12 publications

References 46 publications

The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model

The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model

The ability of yoghurt supplemented with dietary fibers or brans extracted from wheat or rice to reduce serum lipids and enhance liver function in male hypercholesterolemic rats

Study of the impact of a dynamic in vitro model of the colon (TIM-2) in the phenolic composition of two Mexican sauces

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