Capsule endoscopic findings correlate with fecal calprotectin and C-reactive protein in patients with suspected small-bowel Crohn’s disease

Abstract

Inflammatory lesions in the small bowel diagnosed by CE in patients with suspected Crohn´s disease are correlated to fecal calprotectin and CRP, but not to symptoms.

Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy: A Multicenter Retrospective Study

“…Höög et al [7], in a cohort of 30 patients, showed that there was a significant persistent correlation between endoscopic inflammation and FC (at study inclusion and at a year's follow-up). More recently, Olsen et al showed that the proportion of patients with findings on small-bowel CE increased with increasing FC [30].…”

“…In this single-center study, FC [ 100 lg/g is good predictor of positive smallbowel CE findings, while FC [ 200 lg/g was associated with higher CE diagnostic yield (65 %) and confirmed small-bowel inflammation in 50 % of cases. Hence, it is reasonable to consider that strong correlation should exist between FC levels and LS [7][8][9]. However, in a separate cohort of patients with suspected, isolated small-bowel disease, LS showed strong correlation with FC at levels \100 lg/g [8].…”

“…In order to standardize reporting of smallbowel inflammation using CE, two scoring indices have been developed: the Lewis score (LS) and the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) [2][3][4]. Both scores are based on parameters and descriptors of inflammatory change and have been externally validated in several reports [5][6][7][8]. However, they are of limited discriminatory ability, and it is still unclear how accurately they measure the degree of mucosal inflammation [6,9].…”

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohn’s disease

“…Some studies have been published trying to assess the association between symptoms (7,28) or isolated biomarkers with the presence of inflammatory lesions in CE. Regarding laboratory tests, we found some case series in the literature about the usefulness of fecal markers (most of them on FC), with heterogeneous and sometimes conflicting results (8,13,29,30). There are only a few short case series analyzing the association between symptoms and biomarkers together with findings in CE.…”

Elevated Faecal Calprotectin Levels are a Reliable Non-Invasive Screening Tool for Small Bowel Crohn’s Disease in Patients Undergoing Capsule Endoscopy

“…Faecal neutrophil-derived protein, calprotectin, is sensitive but not a disease-specific surrogate marker for intestinal inflammation [5, 6]. While there is growing acceptance of FC as a valuable biomarker of colonic IBD, and there is evidence to show FC correlates with SB inflammation, data on the ability of this faecal biomarker to detect and out rule SB abnormalities in unselected patients is less clear [7]. The clinical role of faecal and serum biomarkers in predicting findings compatible with SB CD as assessed by SBCE in particular has been insufficiently studied.…”