Capsule Endoscopy in Celiac Disease: Diagnosis and Management

Green, Peter H. R.; Rubin, Moshe

doi:10.1016/j.giec.2006.03.003

Cited by 23 publications

(15 citation statements)

References 55 publications

(61 reference statements)

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“…The sensitivity, specificity, PPV, and NPV are in keeping with studies where VCE has been employed in diagnosing new or known CD [22][23][24]. VCE has frequently been reported in the evaluation of the small bowel in CD [22,23,25,26], but here we report an emerging indication in those who fail to respond to a GFD. In those who are truly refractory there is greater risk of developing EATL [13,14].…”

Section: Discussionsupporting

confidence: 85%

A Blinded Pilot Comparison of Capsule Endoscopy and Small Bowel Histology in Unresponsive Celiac Disease

et al. 2008

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This study compares video capsule endoscopy (VCE) with histological specimens of proximal small bowel in patients with celiac disease who have failed to respond to a gluten-free diet. Patients with nonresponsive celiac disease underwent capsule endoscopy, and concordance between endoscopy and histology was then calculated using the kappa statistic. In 19 patients, endoscopy videos were reported as normal in ten (53%) case, as having mild changes in three (16%) cases, and as having moderate-severe changes in six (31%) cases. Two (11%) had acute ulcers. No small bowel tumors were seen. Endoscopy demonstrated concordance with histological changes in 14 of the 18 patients with histology available (78% concordance). The kappa statistic suggested a substantial degree of concordance between histology and endoscopic findings. Endoscopy with distal duodenal biopsies is superior to VCE in detecting proximal, nonresponsive celiac disease, but more distal lesions may be missed such that the strength of VCE lies in its ability to visualize the entire small bowel.

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Section: Discussionsupporting

confidence: 85%

A Blinded Pilot Comparison of Capsule Endoscopy and Small Bowel Histology in Unresponsive Celiac Disease

et al. 2008

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“…In CD, the villi may appear shortened and thickened, layered or stacked folds. In addition to general mucosal pattern, CE can easily recognize finger-like villi [22, 31]. We observed scalloping of the folds, mosaic pattern, nodularity, and layering of folds in CE of our patients with CD (Figure 1).…”

mentioning

confidence: 67%

Capsule Endoscopy in Celiac Disease

Akın

Ersoy²

2012

Gastroenterology Research and Practice

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“…Although videocapsule endoscopy has been commercially available for approximately 10 years, and devices are obtainable from different manufacturers [16,24], the approach is currently used by gastroenterologists as a qualitative assist device when assessing the extent and severity of villous atrophy in celiac patients [25-27]. Gastrointestinal motility is likely altered in untreated celiac disease due to mucosal injury, but this is currently gauged by indirect means i.e., by measuring the transit time from proximal to distal small intestine [1,2].…”

Section: Discussionmentioning

confidence: 99%

Robust spectral analysis of videocapsule images acquired from celiac disease patients

Ciaccio

Tennyson

Bhagat

et al. 2011

BioMedical Engineering OnLine

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BackgroundDominant frequency (DF) analysis of videocapsule endoscopy images is a new method to detect small intestinal periodicities that may result from mechanical rhythms such as peristalsis. Longer periodicity is related to greater image texture at areas of villous atrophy in celiac disease. However, extraneous features and spatiotemporal phase shift may mask DF rhythms.MethodThe robustness of Fourier and ensemble averaging spectral analysis to compute DF was tested. Videocapsule images from the distal duodenum of 11 celiac patients (frame rate 2/s and pixel resolution 576 × 576) were analyzed. For patients 1, 2, ... 11, respectively, a total of 10, 11, ..., 20 sequential images were extracted from a randomly selected time epoch. Each image sequence was artificially repeated to 200 frames, simulating periodicities of 0.2, 0.18, ..., 0.1Hz, respectively. Random white noise at four different levels, spatiotemporal phase shift, and frames with air bubbles were added. Power spectra were constructed pixel-wise over 200 frames, and an average spectrum was computed from the 576 × 576 individual spectra. The largest spectral peak in the average spectrum was the estimated DF. Error was defined as the absolute difference between actual DF and estimated DF.ResultsFor Fourier analysis, the mean absolute error between estimated and actual DF was 0.032 ± 0.052Hz. Error increased with greater degree of random noise imposed. In contrast, all ensemble average estimates precisely predicted the simulated DF.ConclusionsThe ensemble average DF estimate of videocapsule images with simulated periodicity is robust to noise and spatiotemporal phase shift as compared with Fourier analysis. Accurate estimation of DF eliminates the need to impose complex masking, extraction, and/or corrective preprocessing measures.

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Capsule Endoscopy in Celiac Disease: Diagnosis and Management

Cited by 23 publications

References 55 publications

A Blinded Pilot Comparison of Capsule Endoscopy and Small Bowel Histology in Unresponsive Celiac Disease

A Blinded Pilot Comparison of Capsule Endoscopy and Small Bowel Histology in Unresponsive Celiac Disease

Capsule Endoscopy in Celiac Disease

Robust spectral analysis of videocapsule images acquired from celiac disease patients

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