Capsule Endoscopy in Children

Cohen, Stanley A.; Oliva, Salvatore

doi:10.3389/fped.2021.664722

Cited by 15 publications

(11 citation statements)

References 65 publications

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“…Video capsule endoscopy (wireless capsule endoscopy) is established in paediatric practice for patients with IBD. Diagnostic uncertainty following biopsy, strong suspicion of small bowel disease and a drive towards better characterisation of disease extent have all increased the use of this technique 13. It is possible to perform this examination in children as young as 2 years of age.…”

Section: Diagnostic and Referral Strategiesmentioning

confidence: 99%

“…Diagnostic uncertainty following biopsy, strong suspicion of small bowel disease and a drive towards better characterisation of disease extent have all increased the use of this technique. 13 It is possible to perform this examination in children as young as 2 years of age. A dummy, or patency, capsule can be administered prior to the video capsule to ensure this will not be retained by a stricture.…”

Section: Diagnostic and Referral Strategiesmentioning

confidence: 99%

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Inflammatory bowel disease: recent developments

Ashton

Beattie

2023

Arch Dis Child

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Paediatric-onset inflammatory bowel disease (IBD) is a complex and heterogenous condition. Incidence of disease in those aged <18 years has doubled over the last 25 years, with concurrent increased prevalence and no decrease in disease severity. The tools available at diagnosis for investigation have developed over the last 10 years, including use of better utilisation of faecal calprotectin, improved small bowel imaging and video capsule endoscopy. Alongside this, management options have increased and include biological and small molecule therapies targeting alternative pathways (such as interleukin 12/23, integrins and Janus kinase/signal transducers and activators of transcription, JAK-STAT pathways) and better understanding of therapeutic drug monitoring for more established agents, such as infliximab. Dietary manipulation remains an interesting but contentious topic.This review summarises some of the recent developments in the diagnosis, investigation and management of IBD in children and young people. IBD is increasingly recognised as a continuum of disease, with only some patients presenting with Crohn’s disease or ulcerative colitis phenotypes. Future implementation of personalisation and stratification strategies, including clinical and molecular biomarkers, implementation of predictors of response and outcome and use of additional therapies, will continue to require working within clinical networks and multiprofessional teams.

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Section: Diagnostic and Referral Strategiesmentioning

confidence: 99%

Section: Diagnostic and Referral Strategiesmentioning

confidence: 99%

Inflammatory bowel disease: recent developments

Ashton

Beattie

2023

Arch Dis Child

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“…There is extensive pediatric experience with VCE; the established indications include gastrointestinal bleeding and small bowel Crohn's Disease. Small intestinal polyps are detected in 8% of VCE in pediatric patients overall, mainly in older children (>10 years age) with PJS 3 . Several studies have reported the use of VCE in adult and pediatric PJS, including favorable comparison with other radiologic modalities.…”

Section: Introductionmentioning

confidence: 99%

Small Intestinal Polyp Burden in Pediatric Peutz-Jeghers Syndrome

Jeremy,

Nathan,

Vincent

et al. 2023

Preprint

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The management of pediatric Peutz Jeghers Syndrome (PJS) focuses on the prevention of obstruction from intussusception complicating small intestinal polyposis. This hinges on the accurate appraisal of polyp burden to tailor therapeutic intervention. Video capsule endoscopy (VCE) is an established tool to determine small intestinal polyp burden in children but an in-depth characterization of polyp burden in this population with PJS is lacking. Methods: Study design; retrospective longitudinal cross-sectional analysis of VCE studies in pediatric PJS patients followed at our institution 2010 – 2020. Demographic, clinical history, and VCE findings reported by three reviewers in tandem were accrued. Polyp burden variables were modeled as functions of patient and study characteristics using linear mixed models adjusted for clustering. Results:The cohort included 16 patients, mean age 13.4 years at first VCE. Total small bowel polyp count and largest polyp size clustered under 30 polyps and < 20mm with only 4 studies detecting > 10 polyps and polyps > 21 mm in size. Luminal occlusion correlated closely to estimated polyp size. Polyp distribution favored proximal (77%) over distal (66 %) involvement of the small bowel. Adjusted largest polyp size was greater in male over female patients. Double balloon enteroscopy was associated with decreased polyp number and decreased luminal occlusion categories. Discussion: The polyp burden in pediatric PJS favors the proximal third of the small intestine, relatively small numbers, and polyp size amenable to resection through device assisted enteroscopy (DAE). Male gender correlated with larger polyps; older age related to increased polyp number. (247 WORDS)

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“…1 It has been increasingly applied for the investigation of various other conditions, such as suspected or established Crohn's disease (CD), inherited polyposis syndromes, celiac disease, and so on. 1,2 While bowel preparation is an issue to be discussed, colon capsule endoscopy (CCE) has been considered as a painless and radiation-free imaging modality alternative to ileocolonoscopy for the screening of colorectal tumorous lesions, based on the results confirming favorable diagnostic yield of colorectal polyps using the second-generation CCE. 3 In addition, possible application of CCE for ulcerative colitis has been recently discussed.…”

mentioning

confidence: 99%

“…Among them, small bowel capsule endoscopy (SBCE) enables complete visualization of the small intestine noninvasively, and the procedure has been recommended as the first choice of modality in patients with obscure gastrointestinal (GI) bleeding 1 . It has been increasingly applied for the investigation of various other conditions, such as suspected or established Crohn’s disease (CD), inherited polyposis syndromes, celiac disease, and so on 1,2 . While bowel preparation is an issue to be discussed, colon capsule endoscopy (CCE) has been considered as a painless and radiation‐free imaging modality alternative to ileocolonoscopy for the screening of colorectal tumorous lesions, based on the results confirming favorable diagnostic yield of colorectal polyps using the second‐generation CCE 3 .…”

mentioning

confidence: 99%