Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: A randomized, double blind, placebo-controlled, multicenter clinical study

Mao, Yimin; Zeng, Minghui; Lu, Lungen; Wan, Mo-Bin; Li, Chengzhong; Chen, Cheng-Wei; Fu, Qing-Chuen; Wang, Jiyao; She, Weimin; Cai, Xiong; Ye, Jun; Zhou, Xingtao; Wang, Hui; Wu, Shanming; Tang, Meifang; Zhu, Jihe; Chen, Weixiong; Zhang, Hui-Quan

doi:10.3748/wjg.v10.i22.3269

Cited by 58 publications

(31 citation statements)

References 20 publications

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“…Hepatic fibrosis is a known cause of several regional hepatic hemodynamics changes including the hepatic blood flow, resistive index, and the portal vein velocity. 4 In cirrhosis, portal blood inflow, hepatic resistance and portal venous pressure increases. Despite the initial increase, portal blood inflow decreases with increasing sinusoidal resistance and development of portosystemic collateral vessels.…”

Section: Discussionmentioning

confidence: 99%

Role of Colour Doppler in Evaluation of Hemodynamic Changes in Chronic Hepatitis C Infection

Masood¹,

Dogar²,

Gautam³

et al. 2016

Annals KEMU

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Purpose of the Study: The estimation of the degree of hepatic fibrosis is important for diagnostic and therapeutic management of patients with chronic liver disease, in particular those associated with hepatic viral infections. In cirrhosis portal blood inflow, hepatic resistance and portal venous pressure increase. Doppler sonography is non-invasive diagnostic modality based on hemodynamic parameters. Hemodynamic changes might have developed even in cases with normal findings on B mode sonography. Therefore, assessment of these alterations has importance for early diagnosis and for close follow-up of previously dia-

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Section: Discussionmentioning

confidence: 99%

Role of Colour Doppler in Evaluation of Hemodynamic Changes in Chronic Hepatitis C Infection

Masood¹,

Dogar²,

Gautam³

et al. 2016

Annals KEMU

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“…The results of several multicenter RCTs have confirmed that TCM can reverse liver fibrosis [49][50][51] . FZHYC was used to treat liver fibrosis in patients with CHB for six months.…”

Section: Chinese Materia Medica Is Frequently Used To Treat Liver Dismentioning

confidence: 87%

Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities

Zhao

Zhou

Jian

et al. 2014

Journal of Integrative Medicine

104

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Traditional Chinese medicine (TCM) is commonly used in treating liver diseases worldwide, especially in China. The advantages of using TCM for treatment of liver diseases include: protecting hepatocytes, inhibiting hepatic inflammation and antifibrosis in the liver. In this article, we introduce TCM herbal preparations from the Chinese materia medica (such as Fuzheng Huayu) that are typically used for the treatment of liver diseases. Literature surrounding the mechanisms of TCM therapy for treatment of liver diseases is presented and discussed. We propose that side effects of herbal compounds are often under-appreciated, and that more care should be taken in the prescription of potentially hepatotoxic medicines. Further, to deepen the understanding of TCM mechanisms, new techniques and methodologies must be developed. Future studies will lead to the enhancement of clinical outcomes of TCM. As complementary and alternative therapies, TCMs will play an expanding role in the future of liver disease treatment.

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“…Immune-stimulative activity that changes the immune response of HBV-transgenic mice from a Th2 (IL-4 and IL-10) to a Th1 (IFN-γ and IL-2) response has been also reported (Dong et al, 2002;Yang et al, 2002). Because these animal studies and cell-based experiments showed promising effects against HCV infection, several clinical studies have been conducted (Li et al, 1998;Mao et al, 2004). A review paper has evaluated the efficacy of several natural products reported in the treatment of chronic HCV subjects.…”

Section: Oxymatrinementioning

confidence: 99%

Kampo Medicines for Infectious Diseases

Komuro

2017

Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation

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Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: A randomized, double blind, placebo-controlled, multicenter clinical study

Abstract: Oxymatrine capsule is effective and safe in treatment of hepatic fibrosis due to chronic viral hepatitis.

Cited by 58 publications

References 20 publications

Role of Colour Doppler in Evaluation of Hemodynamic Changes in Chronic Hepatitis C Infection

Role of Colour Doppler in Evaluation of Hemodynamic Changes in Chronic Hepatitis C Infection

Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities

Kampo Medicines for Infectious Diseases

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