Captopril

Kadin, Harold

doi:10.1016/s0099-5428(08)60261-0

Cited by 29 publications

(15 citation statements)

References 30 publications

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“…Figure 4 shows pH‐profiles of 13 C‐chemical shift of the C1 carbon in the absence and presence of α‐ and β‐CyDs in the range of pH 2.5–4.0. The C1 carbon was magnetically deshielded (i.e., downfield‐shifted) as pH of solution raised, due to the acid dissociation, in which the inflection point of the profile agreed with pKa 3.7 of captopril reported by Kadin 6. The pH‐profile was negligibly changed by the addition of α‐CyD, whereas it was significantly shifted to higher pH region by the addition of β‐CyD.…”

Section: Resultssupporting

confidence: 72%

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Inclusion Complex Formation of Captopril with α‐ and β‐Cyclodextrins in Aqueous Solution: NMR Spectroscopic and Molecular Dynamic Studies

Ikeda¹,

Motoune²,

Matsuoka³

et al. 2002

Journal of Pharmaceutical Sciences

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Section: Resultssupporting

confidence: 72%

“…No internal reference was used to avoid interference with the binding to CyDs. 1 H‐NMR signals of captopril were assigned by analysis of correlation spectroscopy (COSY) and 13 C‐NMR signals were assigned according to the report of Kadin 6. The concentration of captopril and CyDs was 10.0 mM.…”

Section: Methodsmentioning

confidence: 99%

Inclusion Complex Formation of Captopril with α‐ and β‐Cyclodextrins in Aqueous Solution: NMR Spectroscopic and Molecular Dynamic Studies

Ikeda¹,

Motoune²,

Matsuoka³

et al. 2002

Journal of Pharmaceutical Sciences

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“…The analytical profile of the drug with several references describing its determination in pharmaceutical preparations and in biological fluids up to 1982 has been reviewed [34]. Different spectrophotometric procedures have been reported for the determination of CAP; these include reaction with promethazine [35], palladium II chloride in Britton-Robinson buffer [36], 2,4-dinitroflurobenzene in borate buffer [37], Ellman reagent [38], DTNB [39], chloramines-T [40], chloranilic acid [41], iodate [42], copper II-neocuproine [43], 1,10-phenanthroline [44], potassium ferricyanide [45], carbon disulfide in alkaline medium [46], partial least squares spectrophotometry [47], kinetic spectrophotometry [48], derivative spectrophotometry [49].…”

Section: Research Articlementioning

confidence: 99%

Spectrofluorimetric Estimation of Some Sulfhydryl–Containing Drugs by Demasking Reaction of the Palladium Chelate of 8-Hydroxyquinoline-5-Sulfonic Acid

Rs¹,

Sf²,

Hewala³

et al. 2017

Pharm Anal Acta

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A simple and sensitive spectrofluorimetric method has been developed for the determination of some selected sulfhydryl-containing drugs namely Acetylcysteine (ACS), Captopril (CAP) and Mesna (MSN).The method is based on the interaction of the drugs with potassium (5-sulfoxino) palladium II in alkaline medium in presence of magnesium ions, where the sulfhydryl group combines with palladium from the non-fluorescent potassium bis (5-sulfoxino) palladium II. The resulting 8-hydroxy-5-quinoline sulfonic acid coordinates with magnesium to form the fluorescent chelate that is a measure of the amount of sulfhydrl containing drug analyzed. The fluorescence intensity was measured at an emission wavelength of 485 nm, by excitation at 345 nm. All the experimental parameters affecting the reaction were studied and optimized. The proposed method was applicable over the concentration range of 0.04-0.44 µg/mL for the three drugs and was applied for their determination in bulk form and in pharmaceutical preparations without interference from common excipients. The assay results were statistically compared with those obtained from previously reported methods where no significant difference was found between them. The selectivity and the stability-indicating aspect of the proposed method were confirmed by preparing the disulphides of the studied drugs and applying the reaction to the parent drugs in presence of their disulphides where no interference was detected from these related substances. By virtue of its high sensitivity, the proposed method was also extended to analyze the drugs in spiked human plasma and urine.

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“…Comprehensive reviews to describe the physical, chemical and spectral properties of captopril (42) and enalapril maleate (43) are available.…”

Section: Non-thiol Inhibitorsmentioning

confidence: 99%

Recent Advances in Pharmaceutical Chemistry—angiotensin-Converting Enzyme Inhibitors

Skellern

1989

J Clin Pharm Ther

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Captopril

Cited by 29 publications

References 30 publications

Inclusion Complex Formation of Captopril with α‐ and β‐Cyclodextrins in Aqueous Solution: NMR Spectroscopic and Molecular Dynamic Studies

Inclusion Complex Formation of Captopril with α‐ and β‐Cyclodextrins in Aqueous Solution: NMR Spectroscopic and Molecular Dynamic Studies

Spectrofluorimetric Estimation of Some Sulfhydryl–Containing Drugs by Demasking Reaction of the Palladium Chelate of 8-Hydroxyquinoline-5-Sulfonic Acid

Recent Advances in Pharmaceutical Chemistry—angiotensin-Converting Enzyme Inhibitors

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