Captopril and Enalapril Improve Cognition and Depressed Mood in Hypertensive Patients

Braszko, Jan J.; Karwowska-Polecka, W; Halicka, Dorota; Gard, Paul R.

doi:10.1515/jbcpp.2003.14.4.323

Cited by 84 publications

(57 citation statements)

References 55 publications

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“…Among the affective disorders, the depression can coexist with the development of cardiocirculatory disturbances (Braszko et al 2003). In this condition it is frequent the diagnosis of 5-HTergic hypofunction performed through the proof of the capacity of prolactin release after administration of 5-HT releaser (Meltzer and Lowy 1987).…”

Section: Hypertensionmentioning

confidence: 99%

Role of the serotoninergic system in the sodium appetite control

Reis

2007

An. Acad. Bras. Ciênc.

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The present article reviews the role of the serotoninergic system in the regulation of the sodium appetite. Data from the peripheral and icv administration of serotoninergic (5-HTergic) agents showed the participation of 5-HT2/3 receptors in the modulation of sodium appetite. These observations were extended with the studies carried out after brain serotonin depletion, lesions of DRN and during blockade of 5-HT2A/2C receptors in lateral parabrachial nucleus (LPBN). Brain serotonin depletion and lesions of DRN increased the sodium appetite response, in basal conditions, after sodium depletion and hypovolemia or after beta-adrenergic stimulation as well. These observations raised the hypothesis that the suppression of ascending pathways from the DRN, possibly, 5-HTergic fi bers, modifi es the angiotensinergic or sodium sensing mechanisms of the subfornical organ involved in the control of the sodium appetite. 5-HTergic blockade in LPBN induced to similar results, particularly those regarded to the natriorexigenic response evoked by volume depletion or increase of the hypertonic saline ingestion induced by brain angiotensinergic stimulation. In conclusion, many evidences lead to acceptation of an integrated participation resulting of an interaction, between DRN and LPBN, for the sodium appetite control.

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Section: Hypertensionmentioning

confidence: 99%

Role of the serotoninergic system in the sodium appetite control

Reis

2007

An. Acad. Bras. Ciênc.

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“…In this way, captopril was reported by many authors to have a beneficial effect on cognition, attention and emotional functions (5)(6)(7)16). Also, it was reported that icv administration of Ang II results in increased anxiety-like behavior in rats (17).…”

Section: Discussionmentioning

confidence: 90%

“…Also, it was reported that icv administration of Ang II results in increased anxiety-like behavior in rats (17). In addition, captopril has been suggested to possess antidepressant activity, as shown by specific tests like forced-swimming and learned helplessness (6,18). Still, there are studies which failed to find any effects of captopril on cognition, subjective feeling or mood (8) in human patients.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it seems that drugs affecting RAS influence the anxiety-related behavior, but this varies with the way of administration, the time of testing after drug administration and the animal strain used (5). Regar ding captopril, reports indicating that it has antidepressive effects/enhances well-being in human patients (6) and exerts mood elevating effects in rats (7), are contradicted by studies showing no effect of captopril on subjective feeling or mood in humans (8) or on behavior and cognition in rats (9).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative Stress

Ciobîcă¹,

Hrițcu²,

Năstasă³

et al. 2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Ispitivan je uticaj intracere bro ventrikularne administracije angiotenzina II i kaptoprila na napetost i oksidativni stres u mozgu. Za procenjivanje po na{anja bliskog anksioznosti kori{}en je test uzdignutog lavirinta u obliku znaka plus, dok je biohemijska analiza obu hvatila odre|ivanje nekih enzima antioksidantne odbrane kao {to su superoksid-dismutaza i glutation-peroksidaza i pro izvoda lipidne peroksidacije (malondialdehid). Na{i re zultati predstavljaju jo{ jedan dokaz da angiotenzin II iza ziva posledice nalik na anksioznost i povi{en prooksidantni sta tus.[tavi{e, blokiranje angiotenzina II davanjem inhibitora enzima koji konvertuje angiotenzin (kaptoprila) delo valo je kao anksiolitik i dovelo do sni`enja statusa oksi dativnog stresa. Pored toga, otkrivena je zna~ajna korelacija izme |u vremena koje su pacovi proveli u otvorenim »ruka ma« lavirinta i markera oksidativnog stresa. Ovo mo`da uka zuje na va`nost pokretanja nekih va`nih terapijskih pita nja koja se ti~u anksioliti~kog dejstva nekih inhibitora enzi ma koji konvertuju angiotenzin a koji se pre svega koriste za hipertenziju, kakav je kaptopril. Tako|e, sva je prilika da oksi dativni stres u tome igra va`nu ulogu.

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“…One study reported a greater incidence of depressed mood associated with anxiety and decreased cognitive function in patients with hypertension. These deficits were absent in hypertensives taking ACE inhibitors (Braszko, Karwowska-Polecka, Halicka, & Gard, 2003). Interestingly, patients taking ACE inhibitors or angiotensin II receptor antagonists are more likely to continue drug therapy compared to patients taking other antihypertensive medications (Elliott, Plauschinat, Skrepnek, & Gause, 2007).…”

Section: Definitionmentioning

confidence: 98%