Captopril in the Treatment of Clinical Hypertension and Cardiac Failure

Atkinson, A. B.; Robertson, James I.

doi:10.1016/s0140-6736(79)92186-x

Cited by 374 publications

(142 citation statements)

References 50 publications

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“…Captopril, the first orally active converting enzyme inhibitor, is effective in the treatment of hypertension and congestive cardiac failure (Atkinson & Robertson, 1979;Dargie et al, 1983). Recently, a new group of proline derivatives, lacking a sulphydryl group, has been developed (Patchett et al, 1980).…”

Section: Introduction Methodsmentioning

confidence: 99%

Enalapril (MK421) and its lysine analogue (MK521): a comparison of acute and chronic effects on blood pressure, renin‐angiotensin system and sodium excretion in normal man.

Hodsman¹,

Zabludowski²,

Zoccali³

et al. 1984

Brit J Clinical Pharma

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The immediate and long‐term effects of enalapril (MK421) and its lysine analogue (MK521) in once‐daily dosage, were compared in a study of 12 normal subjects. Both compounds lowered blood pressure equally throughout 24 h without causing tachycardia. The biochemical changes with MK521 were more sustained than with MK421, but this did not affect the magnitude of blood pressure reduction. Twenty‐four hours after the previous dose, with both active drugs, plasma renin concentration was significantly higher on day 8 than on day 1, though angiotensin I did not increase in proportion; this probably reflects a fall in renin‐ substrate with prolonged converting enzyme inhibition. There was an early natriuresis with each compound but this effect was no longer apparent after 8 days of continuous therapy. Both MK421 and MK521 were well tolerated with no serious side effects.

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Section: Introduction Methodsmentioning

confidence: 99%

Enalapril (MK421) and its lysine analogue (MK521): a comparison of acute and chronic effects on blood pressure, renin‐angiotensin system and sodium excretion in normal man.

Hodsman¹,

Zabludowski²,

Zoccali³

et al. 1984

Brit J Clinical Pharma

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“…The renin-angiontensin-aldosterone system is of pathogenetic importance in renovascular hypertension, while no such connection has been found in essential hypertension (Beevers et al, 1977). Captopril can reduce blood pressure both in renovascular and essential hypertension (Atkinson & Robertson 1979;Gavras et al, 1978;Bravo & Tarazi, 1979;Atlas et al, 1979). Opinions differ whether its blood-pressure lowering effect in essential hypertension is correlated with plasma renin activity (Laragh, 1978;Case et al, 1978;Karlberg etal., 1981;Bravo & Tarazi, 1979;Gavras etal., 1978;Johnston et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

Captopril and atenolol combined with hydrochlorothiazide in essential hypertension.

Andrén¹,

Karlberg²,

Svensson³

et al. 1982

Brit J Clinical Pharma

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1 Fifty-seven patients with mild or moderate essential hypertension, mean age 50 (range 31-69) were randomised to treatment with either captopril or atenolol. Twenty-six patients in each group completed the study. 2 Captopril (25-50 mg three times daily) and atenolol (50-100 mg once daily) caused a highly significant fall in blood pressure both supine and standing. 3 When hydrochlorothiazide (25-50 mg once daily) was added a further fall in blood pressure was observed in both groups. 4 Captopril as single drug caused no significant change in heart rate, while atenolol significantly reduced heart rate both supine and standing. 5 Two patients were excluded from the captopril group, one because of a reversible loss of taste and the other because of dizziness. Three patients were excluded from the atenolol group, two because of bradyarrhythmias and one because of inadequate blood pressure response. 6 Both captopril and atenolol were found to be effective antihypertensive agents, suitable for the treatment of essential hypertension.

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“…Thus, repressing ACE activity with ACE inhibitors lowers blood pressure [125]. However, ACE inhibitor drugs such as captopril, enalapril, alacepril and lisinopril that are utilized as anti-hypertensive drugs have a number of side effects such as cough, taste disturbance and skin rashes [126]. Accordingly, natural food-based anti-hypertensive alternatives may offer a valuable alternative.…”

Section: Bioactive Compoundsmentioning

confidence: 99%