Captopril overdose resulting in hypotension

Augenstein, W. Lynn

doi:10.1001/jama.259.22.3302

Cited by 6 publications

(4 citation statements)

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“…MEDLINE was searched from 1966 to 2002 and no previous series of alprazolam poisonings were found. Fourteen case reports have been published including five reported deaths, two in which alprazolam was ingested alone [4–10]. This is potentially significant because benzodiazepine overdose is often thought to be benign.…”

Section: Introductionmentioning

confidence: 99%

Alprazolam is relatively more toxic than other benzodiazepines in overdose

Isbister

O'Regan

Sibbritt

et al. 2004

Brit J Clinical Pharma

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Section: Introductionmentioning

confidence: 99%

Alprazolam is relatively more toxic than other benzodiazepines in overdose

Isbister

O'Regan

Sibbritt

et al. 2004

Brit J Clinical Pharma

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“…There have been reports of over dosages with captopril and enalepril [79][80][81], the main effect is hypotension [82,83] which usually responds to supportive treatment and volume expansion, pressor agents are rarely required. Infusion of angiotensin amide may be considered if hypotension persists [84,85].…”

Section: Overdosagementioning

confidence: 99%

Interaction Studies of ACE Inhibitors with Antidiabetic Drugs

Sattar¹,

Sadia²

2021

Metformin - Pharmacology and Drug Interactions

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Angiotensin converting enzyme (ACE)-inhibitors are effective in patients with mild to moderately severe hypertension, collagen vascular and cardiovascular disease. They are also used in the prevention and treatment of myocardial infarction and in the management of cardiac arrhythmias. Patients with cardiovascular diseases are generally on multiple medicines that’s why it is imperative to study drug–drug interactions of medicines which are commonly taken together in any given case, as combined administration of different medicines can significantly influence the availability of drugs. In the present study we investigated the “in vitro” interactions of ACE inhibitors (enalapril, captopril and lisinopril) with frequently prescribed and co-administered drugs in simulated human body environments. These interactions were monitored by means of UV spectrophotometry and separation technique as RP-HPLC. Prior to start of actual drug interactions, the method of analysis of each drug was established and its various parameters validated for considering its use in testing of drug in vitro as well as in human serum. For this purpose, an attempt was made to develop a number of new HPLC methods for determination of ACE inhibitors (enalapril, captopril and lisinopril) and simultaneously with interacting drugs. These methods were optimized, validated and then successfully employed for the quantitation of enalapril, captopril and lisinopril and selected drugs in interactions studies. As a result, new methods for the quantitation of individual as well as multiple drugs were developed. The interacting drugs selected were antidiabetic drugs (metformin, glibenclamide, glimepride and pioglitazone. Interaction consequences revealed that the availability of enalapril was not affected in presence of antidiabetic drugss whereas the availability of captopril and lisinopril were altered in presence of NIDDMs.

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“…Later snake-derived drugs include a modified version of an antiplatelet toxin produced by the rattlesnake Sistrurus miliarius barbouri, used broadly to treat heart attacks and prevent blood clotting (Phillips & Scarborough, 1997). Both kinds of drugs are dangerous at high doses (Attaya, Kanthi, Aster, & McCrae, 2009;Augenstein, Kulig, & Rumack, 1988;Coons, Barcelona, Freedy, & Hagerty, 2005;Dawson et al, 1990;Parakh, Naik, Rohatgi, Bhat, & Parakh, 2009;Park, Purnell, & Mirchandani, 1990), so it is disingenuous to sustain that whole venoms are lethal but purified compounds are not.…”

Section: Time To Debunk the Prohibition Mythsmentioning

confidence: 99%

Whole Organisms or Pure Compounds? Entourage Effect Versus Drug Specificity

Ribeiro

2018

Plant Medicines, Healing and Psychedelic Science

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As the therapeutic use of sacred plants and fungi becomes increasingly accepted by Western medicine, a tug of war has been taking place between those who advocate the traditional consumption of whole organisms and those who defend exclusively the utilization of purified compounds. The attempt to reduce organisms to single active principles is challenged by the sheer complexity of traditional medicine. Ayahuasca, for example, is a concoction of at least two plant species containing multiple psychoactive substances with complex interactions. Similarly, cannabis contains dozens of psychoactive substances whose specific combinations in different strains correspond to different types of therapeutic and cognitive effects. The "entourage effect" refers to the synergistic effects of the multiple compounds present in whole organisms, which may potentiate clinical efficacy while attenuating side effects. In opposition to this view, mainstream pharmacology is adamant about the need to use purified substances, presumably more specific and safe. In this chapter, I will review the evidence on both sides to discuss the scientific, economic, and political implications of this controversy. The evidence indicates that it is time to embrace the therapeutic complexity of psychedelics. As Western medicine discovers the medicinal properties of whole organisms deemed sacred by traditional cultures, a fierce debate has been set between proponents of the use of purified chemicals versus supporters of long-established ritual uses of plants, fungi, and animals. As a professional neuroscientist with an interest in psychedelic medicines, it is clear to me that the attempt to reduce organisms to single active principles is challenged by the sheer complexity of traditional medicine. Ayahuasca, for example, is a concoction of at least two plant species containing multiple psychoactive substances with a plethora of interactions (Dos Santos et al., 2012; Mckenna, Towers, & Abbott, 1984). Similarly, cannabis contains dozens of psychoactive substances whose specific combinations in different strains correspond to

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Captopril overdose resulting in hypotension

Cited by 6 publications

References 0 publications

Alprazolam is relatively more toxic than other benzodiazepines in overdose

Alprazolam is relatively more toxic than other benzodiazepines in overdose

Interaction Studies of ACE Inhibitors with Antidiabetic Drugs

Whole Organisms or Pure Compounds? Entourage Effect Versus Drug Specificity

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