Captopril potentiates chronotropic baroreflex responses to carotid stimuli in humans.

Ebert, Thomas J.

doi:10.1161/01.hyp.7.4.602

Cited by 36 publications

(14 citation statements)

References 30 publications

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“…Diuretics, angiotensin-converting enzyme inhibitors and calcium channel antagonists lower BP equally well, but they do not appear to increase baroreflex sensitivity consistently. 2,[15][16][17][18][19][20][21][22] For example, in previous reports, captopril increased Figure 2 Absence of relationship between changes in arterial baroreflex sensitivity for heart rate (Log (BRS)) and changes in the variability of ambulatory awake arterial blood pressure (n = 34, r = −0.08, P Ͼ 0.6).…”

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confidence: 80%

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Baroreflex sensitivity and the blood pressure response to β-blockade

et al. 1999

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The objective of this analysis was to determine whether changes in baroreflex sensitivity (BRS) within 35 hypertensive patients (25 M, 10 F, mean age 47 years) treated with ␤-blockade as monotherapy relate to reductions in ambulatory blood pressure (BP) or its variability. BP was recorded intra-arterially directly from the brachial artery before and during submaximal exercise. BRS was determined by the phenylephrine injection technique. MAP and its variability were determined for the awake period of 24-h BP monitoring. Subjects were randomised to one of atenolol, metoprolol, pindolol, or propranolol, and restudied after a mean of 5 months. ␤-blockade increased BRS in 24 patients and decreased BRS in 11. BRS increased from 6.53 ؎ 4.94 to 9.40 ؎ 8.62 ms/mm Hg (mean ؎ s.d.) (P Ͻ 0.01). Waking ambulatory MAP decreased from 125.8 ؎ 15.8 to 106.4 ؎ 16.2 mm Hg (P Ͻ 0.0001), but its variability did not change. Higher BRS after chronic ␤-blockade was associated with a decrease in waking ambulatory MAP (r ‫؍‬ ؊0.55,

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confidence: 80%

“…baroreflex sensitivity in normotensive and hypertensive humans, 15,16 and lisinopril in elderly hypertensives, 17 whereas ramipril, in a dose therapeutically equal to metoprolol, had no such effect. 2 There are conflicting reports on the effects of calcium channel antagonists on baroreflex sensitivity.…”

Section: Figurementioning

confidence: 96%

Baroreflex sensitivity and the blood pressure response to β-blockade

et al. 1999

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“…Angiotensin II can influence cardiovascular control mechanisms in man (50) and alter responses to AVP infusion in rats (35). Therefore, captopril was given to prevent changes in plasma angiotensin II which may have occurred during AVP infusion or lbnp exposure.…”

Section: Methodsmentioning

confidence: 99%

Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.

Ebert¹,

Cowley²,

Skelton³

1986

J. Clin. Invest.

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We examined the effects of physiologic infusions of arginine vasopressin (AVP) on cardiovascular hemodynamics and on reflex responses initiated by decreasing cardiopulmonary baroreceptor stimulation (with lower body negative pressure) in 10 healthy, captopril-pretreated young men (19-27 yr). Their responses were compared with those of four volunteers given isosmotic infusion. Heart rate, stroke volume, blood pressure, and forearm blood flow were measured by electrocardiography, impedance cardiography, radial artery cannulation, and strain gauge plethysmography. Two 55-min infusions of AVP at rates of 0.15 and 0.40 ng/kg per min increased average plasma concentrations from control levels of 5 pg/ml to 18 and 36 pg/ml, respectively. These infusions resulted in progressive reductions of heart rate and cardiac output and increases of forearm and total peripheral resistance. Blood pressure increases were significant only during the larger AVP infusion rate. Lower body negative pressure provoked reflex increases of total peripheral resistance. These increases were enhanced 60% during AVP infusion compared with increases during control (pre-AVP). Baseline measurements and reflex responses were unchanged by isosmotic infusions. These results demonstrate that AVP has profound effects on cardiovascular function and augments cardiopulmonary baroreflex-mediated increases of peripheral resistance in man.

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“…31 This author suggested that captopril potentiates reflex-mediated bradycardia via a reduction in central nervous system angiotensin II levels, which augments vagal responses to carotid baroreceptor stimuli. Since ANF has been reported to antagonize some of the vascular, 16 adrenal 432 " 34 and central nervous system 35 effects of angiotensin n, it also seems possible that the ANF-induced enhancement in vagal tone might somehow be related to functional antagonism of angiotensin II central effects.…”

Section: Figure 4 Reflex Chronotropic Responses (A//pj (Mean ± Sem) mentioning

confidence: 99%

Vagal mediation of the effects of atrial natriuretic factor on blood pressure and arterial baroreflexes in the rabbit.

Volpe

Cuocolo

Vecchione

et al. 1987

Circulation Research

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We investigated the hemodynamic effect of synthetic atrial natriuretic factor Auriculin A (ANF) and its influence on arterial baroreflex control of heart rate, systemic blood pressure, and perfuslon pressure in the hind limb (perfused at constant flow) in rabbits anesthetized with a-chloralose and urethane. The neural mechanisms underlying these effects were also studied. In the intact animal, a 45-minute constant infusion of ANF (2 /xg/kg prime, 0.2 /ig/kg/min) significantly reduced mean blood pressure and increased mean perfusion pressure, while heart rate did not change. Comparable data were obtained with lower (0.5 fj-gfkg + 0.05 /xg/kg/min; 1 /tg/kg + 0.1 /xg/kg/mln) or higher (4 Mg/fcg + 0.4 /xg/kg/min; 8 /xg/kg + 0.8 /ig/kg/min) doses of ANF. In addition, ANF enhanced bradycardic reflex responses to phenylephrine i.v. bolus administration, while it did not change baroreflexmediated responses to nitroglycerin i.v. bolus administration and to 30-second bilateral carotid occlusion. The specificity of the influence of ANF on arterial baroreflex responses was confirmed by the observation that no significant change in reflex responses to phenylephrine or carotid occlusion was detectable during a comparable decrease in blood pressure induced by a constant infusion of nitroglycerin. Bilateral vagotomy prevented both the fall in blood pressure and the increase in perfusion pressure induced by ANF, while cholinergic blockade (atropine, 0.5 mg/kg i.v.) or adrenergic blockade (propranolol, 0.3 mg/kg i.v. + phentolamine, 0.3 mg/kg i.v.) did not modify the hemodynamic response to ANF observed in the intact animal. The ANF-induced enhancement of the reflex bradycardie response to phenylephrine-induced rise in blood pressure was prevented by both vagotomy and atropine. In conclusion, our data suggest that in this experimental model an increase in parasympathetic tone is involved in the blood pressure lowering effect of synthetic ANF as well as in the potentiation of the reflex brady cardie response to phenylephrine-induced arterial baroreceptor loading caused by the peptide. (Circulation Research 1987;60:747-755) I n their initial studies on atrial natriuretic factor (ANF), de Bold and coworkers 1 observed that, in addition to the characteristic natriuretic effect, the injection of atrial extracts in rats induced a slight but consistent reduction in blood pressure. This effect was later confirmed with synthetic ANF peptides in both conscious and anesthetized normotensive and hypertensive animals 2 " 9 and in man. 10 " 13The blood pressure lowering effect of ANF was originally attributed to its vasodilator properties, but recent studies seem to indicate that more complex hemodynamic mechanisms are involved in the response to ANF administration. In particular, it has been reported that bolus or sustained infusion of ANF can lower cardiac output.914 " 16 The intrinsic mechanisms that lead to a reduction in cardiac output in response to ANF have not yet been defined. In this regard, Ackermann et al 17 showed that the hypo...

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Captopril potentiates chronotropic baroreflex responses to carotid stimuli in humans.

Cited by 36 publications

References 30 publications

Baroreflex sensitivity and the blood pressure response to β-blockade

Baroreflex sensitivity and the blood pressure response to β-blockade

Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.

Vagal mediation of the effects of atrial natriuretic factor on blood pressure and arterial baroreflexes in the rabbit.

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