Capture of Stealth Nanoparticles by the Body’s Defences

Moghimi, Seyed Moein; Hunter, A. Christy

doi:10.1615/critrevtherdrugcarriersyst.v18.i6.30

Cited by 147 publications

(99 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydrophilic coating of NPs changes the physicochemical characteristics of NPs. This inhibits opsonization, which is the precipitation of antibodies and other proteins on the surface of NPs (8). This strategy was shown to successfully prolong the circulation time of NPs and also enhanced the distribution of NPs to some organs such as the brain (9).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Toxicity of Polysorbate-80-coated Inhalable Nanoparticles; In vitro and In vivo Evaluation

AlHallak

Azarmi

Sun

et al. 2010

AAPS J

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Pulmonary Toxicity of Polysorbate-80-coated Inhalable Nanoparticles; In vitro and In vivo Evaluation

AlHallak

Azarmi

Sun

et al. 2010

AAPS J

View full text Add to dashboard Cite

“…Once in the bloodstream, these nanoparticles are rapidly opsonized and massively cleared by the fixed macrophages of the mononuclear phagocyte system (MPS) organs such as Kupffer cells of the liver and macrophages of the spleen (Grislain et al 1983;Moghimi and Hunter 2001). When associated with nanoparticles, drugs concentrate mainly in the liver and spleen and are precluded from exerting their acute toxicity in other organs.…”

mentioning

confidence: 99%

Etoposide Loaded PLGA and PCL Nanoparticles II: Biodistribution and Pharmacokinetics after Radiolabeling with Tc-99m

et al. 2008

View full text Add to dashboard Cite

“…Lipid structures have been largely developed for various administration routes [1]. In the case of an intravenous administration, many studies [2] have shown that nanoparticles are rapidly removed from the blood stream because of the recognition by cells of the mononuclear phagocytic system. This constitutes the main limit of intravenously administered long circulating drug delivery systems.…”

mentioning

confidence: 99%

Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface

et al. 2005

View full text Add to dashboard Cite

Lipid nanocapsules (LNCs) containing poly(ethylene glycol) (PEG) were developed according to a phase inversion process without organic solvent. The distribution of PEG chains at the surface was determined due to electrokinetic properties, in order to correlate it with protein adsorption potentiality. In this aim, electrophoretic mobilities were measured as a function of ionic strength and pH, for particles differing by their size, dialysis effects, and the presence or not of lecithin in their shell. The study allowed the determination of the isoelectric point (pI) as well as the charge density (ZN) in relation with the dipolar distribution in the polyelectrolyte accessible layer (depth = 1/lambda), by using soft-particle electrophoresis analysis. These parameters pointed out that the PEG surface organization was dependent on the particle size. Moreover, this organization could be modified by dialyzing particles and/or by formulating them with or without lecithin. Lecithin was found to be present in the inner part of the polyelectrolyte layer and to play a role in the outer part disorganization. Dialyzing LNCs formulated with lecithin allowed to obtain stable and well-structured nanocapsules, ready to an in vivo use as drug delivery system.

show abstract

Capture of Stealth Nanoparticles by the Body’s Defences

Cited by 147 publications

References 0 publications

Pulmonary Toxicity of Polysorbate-80-coated Inhalable Nanoparticles; In vitro and In vivo Evaluation

Pulmonary Toxicity of Polysorbate-80-coated Inhalable Nanoparticles; In vitro and In vivo Evaluation

Etoposide Loaded PLGA and PCL Nanoparticles II: Biodistribution and Pharmacokinetics after Radiolabeling with Tc-99m

Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface

Contact Info

Product

Resources

About