CAR-based cell therapy: evaluation with bibliometrics and patent analysis

Yuan, Yajun; Fu, Qihan; Zhang, Yaqun; Xu, Danhai; Wu, Yue; Qiu, Qiufei; Zhou, Wuyuan

doi:10.1080/21645515.2021.1947100

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Moreover, it can guide funding decisions and experimental strategies by providing effective evidence (11). Over the years, fruits of bibliometric research have blossomed from a variety of fields, such as in gouty arthritis (12), traditional Chinese medicine in the field of ischemia-reperfusion injury (13), prenatal stress (14), artemisinin (11), polycystic ovary syndrome (15), the culinary heritage significance of Filipino kakanin (16), metformin (17), evidence-based nursing guidelines for preventing inpatient falls (18), and chimeric antigen receptor-based cell therapy (19). However, no bibliometric analyses of ONFH have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Worldwide research trends on femur head necrosis (2000–2021): a bibliometrics analysis and suggestions for researchers

Zhang¹,

Du²,

Liu³

et al. 2023

Ann Transl Med

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Background: Osteonecrosis of the femoral head (ONFH) is a common and stubborn disease. The main causes are venous stasis of the femoral head, arterial blood supply damage, bone cell and bone marrow death, and bone tissue necrosis and subsequent repair obstacles. Over the past 22 years, the number of papers on ONFH has, overall, continued to increase.Methods: Using bibliometrics, we investigated the trends, frontiers, and hotspots of global scientific output in the past 22 years. We searched Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (WoSCC) and retrieved information associated with papers and records published between 2000 and 2021. We used VOSviewer and CiteSpace to conduct bibliometric analysis and visual analysis on the overall distribution of annual output, major countries, active institutions, journals, authors, commonly cited literature, and keywords. The impact and quality of the papers were assessed using the global citation score (GCS).Results: We retrieved a total of 2006 articles and reviews. Over the past 22 years, the number of publications (NP) increased. China ranked first in terms of NP, while the United States had the highest h-index and the highest number of citations (NC). Shanghai Jiao Tong University and International Orthopaedics were the institution and periodical, respectively. The paper written by Mont et al. in 2006 had the highest total GCS score, at 379. The top three keywords were "ischemic necrosis", "osteonecrosis", and "hip joint". Although there was a fluctuation in publications associated with ONFH, overall, the NP increased. China was the most prolific in this area, while the United States was the most influential country. The top 3 authors in terms of NP were Zhang, Motomura, and Zhao. Areas of focus in ONFH over recent years include signal pathway, genetic differentiation, glucocorticoid-induced osteogenesis, induced ischemic necrosis and osteogenesis. Conclusions: Our bibliometrics analysis revealed the research hotspots and rapid development trends of ONFH research in the past 22 years. The most critical indicators [researchers, countries, research institutions, and journals publishing osteonecrosis of the femoral head (ONFH) research] relevant to the research hotspots in the field of ONFH research were analyzed.

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Section: Introductionmentioning

confidence: 99%

Worldwide research trends on femur head necrosis (2000–2021): a bibliometrics analysis and suggestions for researchers

Zhang¹,

Du²,

Liu³

et al. 2023

Ann Transl Med

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Current status and future prospects of chimeric antigen receptor-T cell therapy in lymphoma research: A bibliometric analysis

Ou,

Su,

Liang

et al. 2023

Human Vaccines & Immunotherapeutics

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CAR-T cell therapy, a novel therapeutic approach that has attracted much attention in the field of cancer treatment at present, has become the subject of many studies and has shown great potential in the treatment of hematological malignancies, such as leukemia and lymphoma. This study aims to analyze the characteristics of articles published on CAR-T cell therapy in the lymphoma field and explore the existing hotspots and frontiers. The relevant articles published from 2013 to 2022 were retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, Bibliometric online analysis platform, Microsoft Excel, and R software were used for bibliometric analysis and visualization. The number of publications related to the research has been increasing year by year, including 1023 articles and 760 reviews from 62 countries and regions, 2092 institutions, 1040 journals, and 8727 authors. The United States, China, and Germany are the main publishing countries in this research field. The top 10 institutions are all from the United States, the journal with the highest impact factor is BLOOD , the author with the most publications is Frederick L Locke, and the most influential author is Carl H June. The top three keywords are “Lymphoma,” “Immunotherapy,” and “Therapy.” “Maude (2014)” is the most cited and strongest burstiness reference over the past decade. This study provides a comprehensive bibliometric analysis of CAR-T cell therapy in lymphoma, which can help researchers understand the current research hotspots in this field, explore potential research directions, and identify future development trends.

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MedTech innovation identification: A rapid scoping review of patent research studies to inform horizon scanning methods

Garcia Gonzalez-Moral,

Pennock,

Ewedairo

et al. 2024

Preprint

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Objectives: This study investigates the role of and methods for patent analysis in advancing medical technology (MedTech) innovation, a sector characterized by diverse, non-pharmacological or non-immunological healthcare technologies and significant research investment. Patents are critical early indicators of innovation, supporting horizon scanning and weak signal detection. The study aimed to identify intellectual property sources, evaluate methods for patent retrieval and analysis, and outline objectives for using patent data to anticipate trends and inform healthcare strategies. It also offered a methodological framework to support stakeholders in adopting innovative MedTech solutions. Methods: A rapid review (RR) was conducted using Cochrane Rapid Review Methods and PRISMA guidelines, with a pre-registered protocol on the Open Science Framework. Searches in Embase, IEEE Xplore, and Web of Science targeted records from 2020 onwards. Three independent reviewers screened studies using Rayyan. We included any study type, published since 2020 that provided sufficient data on patent sources, methods and tools applied to the study of MedTech. Our data extraction included bibliographic details, study characteristics, and methodological information. Risk of bias assessments were not undertaken. Narrative and tabular methods, supplemented by visual charts, were employed to synthesise findings. Results: Our searches identified 1,741 studies, of which 124 were included after title, abstract, and full-text screening, with 54% being original research, 44% reviews, and the remainder being conference abstracts. Most studies (68%) relied solely on patent databases, while others searched the grey literature. Research objectives of the included studies were grouped into nine themes, with trend analysis (50%) and policy recommendations (20%) being the most common. The review analysed 199 patent databases, with 27% of studies using multiple sources. Time horizons for patent searches averaged 24.6 years, ranging from 1900 to 2019. Automated approaches, employed in 33% of studies, frequently utilised tools like Gephi for network visualization. Disease mapping, based on NICE classification, indicated that cancer (19%) and respiratory conditions (16%), particularly COVID-19, were key areas, while digital health dominated the "health and social care delivery" category. Conclusions: The review highlights the value of patent data in trend analysis and its broader role in shaping policies and research strategies. While patents provide crucial insights into emerging technologies, inconsistent de-duplication practices across studies pose a risk of data inflation, accentuating the need for transparency and rigour. Finally, this review emphasized the importance of data transformation and visualization in detecting emerging trends with Python and R being the most commonly used programming languages for developing custom tools.

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CAR-based cell therapy: evaluation with bibliometrics and patent analysis

Cited by 3 publications

References 54 publications

Worldwide research trends on femur head necrosis (2000–2021): a bibliometrics analysis and suggestions for researchers

Worldwide research trends on femur head necrosis (2000–2021): a bibliometrics analysis and suggestions for researchers

Current status and future prospects of chimeric antigen receptor-T cell therapy in lymphoma research: A bibliometric analysis

MedTech innovation identification: A rapid scoping review of patent research studies to inform horizon scanning methods

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