CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy

Taheri, Mohadeseh Mohammad; Javan, Fatemeh; Poudineh, Mohadeseh; Athari, Seyyed Shamsadin

doi:10.1007/s12016-024-08998-0

Clinic Rev Allerg Immunol

2024

DOI: 10.1007/s12016-024-08998-0

|View full text |Cite

CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy

Mohadeseh Mohammad Taheri,

Fatemeh Javan,

Mohadeseh Poudineh

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 346 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

CAR-iNKT cell therapy: mechanisms, advantages, and challenges

Wang,

Zhang

2025

Current Research in Translational Medicine

View full text Add to dashboard Cite

CAR-iNKT cell therapy: mechanisms, advantages, and challenges

Wang,

Zhang

2025

Current Research in Translational Medicine

View full text Add to dashboard Cite

Beyond CAR-T: The rise of CAR-NK cell therapy in asthma immunotherapy

Mohammad Taheri,

Javan,

Poudineh

et al. 2024

J Transl Med

View full text Add to dashboard Cite

Asthma poses a major public health burden. While existing asthma drugs manage symptoms for many, some patients remain resistant. The lack of a cure, especially for severe asthma, compels exploration of novel therapies. Cancer immunotherapy successes with CAR-T cells suggest its potential for asthma treatment. Researchers are exploring various approaches for allergic diseases including membrane-bound IgE, IL-5, PD-L2, and CTLA-4 for asthma, and Dectin-1 for fungal asthma. NK cells offer several advantages over T cells for CAR-based immunotherapy. They offer key benefits: (1) HLA compatibility, meaning they can be used in a wider range of patients without the need for matching tissue types. (2) Minimal side effects (CRS and GVHD) due to their limited persistence and cytokine profile. (3) Scalability for “off-the-shelf” production from various sources. Several strategies have been introduced that highlight the superiority and challenges of CAR-NK cell therapy for asthma treatment including IL-10, IFN-γ, ADCC, perforin-granzyme, FASL, KIR, NCRs (NKP46), DAP, DNAM-1, TGF-β, TNF-α, CCL, NKG2A, TF, and EGFR. Furthermore, we advocate for incorporating AI for CAR design optimization and CRISPR-Cas9 gene editing technology for precise gene manipulation to generate highly effective CAR constructs. This review will delve into the evolution and production of CAR designs, explore pre-clinical and clinical studies of CAR-based therapies in asthma, analyze strategies to optimize CAR-NK cell function, conduct a comparative analysis of CAR-T and CAR-NK cell therapy with their respective challenges, and finally present established novel CAR designs with promising potential for asthma treatment.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy

Cited by 2 publications

References 346 publications

CAR-iNKT cell therapy: mechanisms, advantages, and challenges

CAR-iNKT cell therapy: mechanisms, advantages, and challenges

Beyond CAR-T: The rise of CAR-NK cell therapy in asthma immunotherapy

Contact Info

Product

Resources

About