Car painters` exposure to a mixture of organic solvents. Serum activities of liver enzymes.

Kurppa, Kari; Husman, Kaj

doi:10.5271/sjweh.2491

Cited by 50 publications

(27 citation statements)

References 4 publications

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“…Five biochemical variables were tested, and well over half of the worke rs (65%) had at least one variable above the local laboratory refere nce limit. Comp aring our findings with those reported for groups of other paint industry workers is problematic, as factors such as alcohol usage, obesity, exposure intensity, and reference values can vary among the groups, but it is nevertheless interesting that this group had a much greater prevalence of values outside the reference range and far higher mean enzyme activities than has been reported in other studies of paint industry workers (4)(5)(6)14). Two factors should, however, be considered when these findings are interpreted.…”

Section: Discussioncontrasting

confidence: 48%

“…Many studies reporting liver injury in exposed workers are based on mortality data (1) or case series often without an adequate comparison group or complete exposure data (2)(3)(4). Furthermore, negative studies are well represented in the literature (5)(6)(7), although their value is limited to some extent by the small number of workers with heavy solvent exposure.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Solvent exposure, alcohol consumption and liver injury in workers manufacturing paint.

Rees

Söderlund²,

Cronje³

et al. 1993

Scand J Work Environ Health

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Section: Discussioncontrasting

confidence: 48%

mentioning

confidence: 99%

Solvent exposure, alcohol consumption and liver injury in workers manufacturing paint.

Rees

Söderlund²,

Cronje³

et al. 1993

Scand J Work Environ Health

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“…Alterations in the metabolic rate The occupational exposure to organic solvents had no effect on the apparent clearance of toluene (5), known as hepatotoxins. The findings of no effects on the metabolic capacity from the occupational exposure to solvents conform with recent investigations in which the authors claim normal serum activities of liver enzymes after chronic solvent exposure in man (15,17,32). The subjects in these studies, including the present one, were fully fit for work and had not asked for health care because of suspected solvent intoxication.…”

Section: Discussionsupporting

confidence: 75%

Toxicokinetics of toluene in occupationally exposed volunteers.

Wallén¹

1986

Scand J Work Environ Health

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“…The predominant occupational exposure scenario is inhalation exposure to mixtures of organic solvents (Hänninen et al 1976;Kurppa & Husman 1982;Struwe & Wennberg 1983;Spurgeon et al 1992;Ulfvarson 1992). White spirit is such a mixture, associated with CNS effects in man.…”

mentioning

confidence: 99%

Four Weeks' Inhalation Exposure of Long Evans Rats to 4‐tert‐Butyltoluene: Effect on Evoked Potentials, Behaviour, and Brain Neurochemistry

Lam

Ladefoged

Østergaard

et al. 2000

Pharmacology & Toxicology

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Long-lasting central nervous system (CNS) neurotoxicity of 4-tert-butyltoluene (TBT) has been investigated using electrophysiology, behaviour, and neurochemistry in Long Evans rats exposed by inhalation to 0, 20, or 40 p.p.m. TBT 6 hr/day, 7 days/week for 4 weeks. Flash evoked potentials and somatosensory evoked potentials were not affected by TBT. In Auditory Brain Stem Response there was no shift in hearing threshold, but the amplitude of the first wave was increased in both exposed groups at high stimulus levels. Three to four months after the end of exposure, behavioural studies in Morris water maze and eight-arm maze failed to demonstrate any TBT induced effects. Exposure was followed by a 5 months exposure-free period prior to gross regional and subcellular (synaptosomal) neurochemical investigations of the brain. TBT reduced the NA concentration in whole brain minus cerebellum. Synaptosomal choline acetyltransferase activity increased and acetylcholinesterase activity was unchanged suggesting increased synaptosomal ability for acetylcholine synthesis. The relative and total yield of synaptosomal protein was reduced suggesting reduced density and total number of synapses in situ, respectively. We hypothesise that a reduced yield of synaptosomal protein reflects a more general effect of organic solvent exposure on the software of the brain. The synaptosomal concentration per mg synaptosomal protein and the total amount of 5-hydroxytryptamine were not affected whereas the total amount of synaptosomal noradrenaline decreased. The concentration and the total amount of synaptosomal dopamine decreased. The noradrenergic and dopaminergic parts of CNS may be more vulnerable to TBT than the serotonergic, and these long-lasting effects may cause or reflect TBT-compromised CNS function.

show abstract

Car painters` exposure to a mixture of organic solvents. Serum activities of liver enzymes.

Cited by 50 publications

References 4 publications

Solvent exposure, alcohol consumption and liver injury in workers manufacturing paint.

Solvent exposure, alcohol consumption and liver injury in workers manufacturing paint.

Toxicokinetics of toluene in occupationally exposed volunteers.

Four Weeks' Inhalation Exposure of Long Evans Rats to 4‐tert‐Butyltoluene: Effect on Evoked Potentials, Behaviour, and Brain Neurochemistry

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