Características clínicas y epidemiológicas de pacientes hospitalizados por infección por SARS-CoV-2 en dos hospitales en Córdoba

Saad, Emanuel José; Barovero, María Antonella Correa; Marucco, Federico Ariel; Bonazzi, Silvina Trinidad Rodríguez; Barra, Ayelén Tarditi; Zlotogora, Melani; Villada, Sofía María; Barrionuevo, Augusto Douthat Y; Heredia, María Celeste; Caeiro, Juan Pablo; Fernández, Pehuén; Albertini, Ricardo Arturo

doi:10.31053/1853.0605.v78.n3.32518

Cited by 7 publications

(8 citation statements)

References 22 publications

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“…Reverse transcriptase polymerase chain reaction (RT-PCR) (PerkinElmer ® , Massachusetts, U.S) was performed in nasal and pharyngeal swab samples ( 21 ). Only hospitalized patients were recruited (n=118) and classified as moderate or severe COVID-19 according to clinical parameters ( 25 , 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples from HC were obtained at the beginning of the study, during the first wave. HC had no previous history of SARS-CoV-2 infection diagnosed either by positive SARS-CoV-2 nucleic acid amplification test, compatible symptoms, or epidemiological close-contact criteria ( 21 , 25 ). None of the participants, including HC, received a COVID-19 vaccine before their inclusion in this study.…”

Section: Methodsmentioning

confidence: 99%

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Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities

et al. 2023

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BackgroundCOVID-19 severity has been linked to an increased production of inflammatory mediators called “cytokine storm”. Available data is mainly restricted to the first international outbreak and reports highly variable results. This study compares demographic and clinical features of patients with COVID-19 from Córdoba, Argentina, during the first two waves of the pandemic and analyzes association between comorbidities and disease outcome with the “cytokine storm”, offering added value to the field.MethodsWe investigated serum concentration of thirteen soluble mediators, including cytokines and chemokines, in hospitalized patients with moderate and severe COVID-19, without previous rheumatic and autoimmune diseases, from the central region of Argentina during the first and second infection waves. Samples from healthy controls were also assayed. Clinical and biochemical parameters were collected.ResultsComparison between the two first COVID-19 waves in Argentina highlighted that patients recruited during the second wave were younger and showed less concurrent comorbidities than those from the first outbreak. We also recognized particularities in the signatures of systemic cytokines and chemokines in patients from both infection waves. We determined that concurrent pre-existing comorbidities did not have contribution to serum concentration of systemic cytokines and chemokines in COVID-19 patients. We also identified immunological and biochemical parameters associated to inflammation which can be used as prognostic markers. Thus, IL-6 concentration, C reactive protein level and platelet count allowed to discriminate between death and discharge in patients hospitalized with severe COVID-19 only during the first but not the second wave.ConclusionsOur data provide information that deepens our understanding of COVID-19 pathogenesis linking demographic features of a COVID-19 cohort with cytokines and chemokines systemic concentration, presence of comorbidities and different disease outcomes. Altogether, our findings provide information not only at local level by delineating inflammatory/anti-inflammatory response of patients but also at international level addressing the impact of comorbidities and the infection wave in the variability of cytokine and chemokine production upon SARS-CoV-2 infection.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities

et al. 2023

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“…No primeiro quadrimestre de 2021, o painel de análise do excesso de mortalidade por causas naturais no Brasil apontava 64% de mortes a mais do esperado, sendo homens os mais afetados 21 . Outros fatores de risco a serem considerados são a presença de algumas comorbidades que, no caso da COVID-19, têm desempenhado um papel importante 24 , com destaque para o diabetes, doenças pulmonares préexistentes, obesidade, entre outras 21,24,25 .…”

Section: Discussionunclassified

Estimativa do excesso de mortalidade em hospital universitário do Paraná durante a pandemia de COVID-19

Obregón

Erdmann

2022

R. Saúde Públ. Paraná

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O sistema de saúde no Brasil ficou sobrecarregado com o surgimento do novo Coronavírus (COVID-19). Neste contexto, foi estudado o excesso de mortes ocorrido em um hospital universitário do Paraná, no período de 2020 a 2021. Foi realizada uma análise transversal retrospectiva dos dados de mortalidade e foi calculado o excesso de mortalidade para o período citado. Constatou-se um aumento de 83,9% de mortes no Hospital Universitário do Oeste do Paraná no período de estudo, cujo percentual foi de 45,2% para 2020 e ultrapassou quase três vezes (122,6%) em 2021. O percentual de mortalidade foi maior para homens, pessoas com idade acima de 60 anos e com residência fora do município de Cascavel. Dentre as causas de morte declaradas, a COVID-19 foi a que teve maior predominância, representando 18,6% e 44,9% em 2020 e 2021, respectivamente.

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“…Reverse transcriptase polymerase chain reaction (RT-PCR) (PerkinElmer ® , Massachusetts, U.S) analysis was conducted on samples obtained from nasal and pharyngeal swabs ( 1 ). Only hospitalized, primo-infection cohorts were recruited, and were classified as patients with moderate (n=52) or severe COVID-19 disease (n=32) according to clinical parameters ( 29 , 30 ). In the current study, we employed multiple risk assessment scores to quantify the severity of COVID-19 disease ( 29 , 30 ).. Additionally, we integrated clinical judgement as a crucial determinant in the process of assigning appropriate admission as patients with moderate or severe disease.…”

Section: Methodsmentioning

confidence: 99%

“…Only hospitalized, primo-infection cohorts were recruited, and were classified as patients with moderate (n=52) or severe COVID-19 disease (n=32) according to clinical parameters ( 29 , 30 ). In the current study, we employed multiple risk assessment scores to quantify the severity of COVID-19 disease ( 29 , 30 ).. Additionally, we integrated clinical judgement as a crucial determinant in the process of assigning appropriate admission as patients with moderate or severe disease. The categorization into moderate or severe was determined upon admission.…”

Section: Methodsmentioning

confidence: 99%

COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity

Onofrio,

Marin,

Dutto

et al. 2023

Front. Immunol.

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This work examines cellular immunity against SARS-CoV-2 in patients from Córdoba, Argentina, during two major waves characterized by different circulating viral variants and different social behavior. Using flow cytometry, we evaluated the main lymphocyte populations of peripheral blood from hospitalized patients with moderate and severe COVID-19 disease. Our results show disturbances in the cellular immune compartment, as previously reported in different cohorts worldwide. We observed an increased frequency of B cells and a significant decrease in the frequency of CD3+ T cells in COVID-19 patients compared to healthy donors (HD). We also found a reduction in Tregs, which was more pronounced in severe patients. During the first wave, the frequency of GZMB, CD107a, CD39, and PD-1-expressing conventional CD4+ T (T conv) cells was significantly higher in moderate and severe patients than in HD. During the second wave, only the GZMB+ T conv cells of moderate and severe patients increased significantly. In addition, these patients showed a decreased frequency in IL-2-producing T conv cells. Interestingly, we identified two subsets of circulating CD8+ T cells with low and high CD8 surface expression in both HD and COVID-19 patients. While the percentages of CD8hi and CD8lo T cells within the CD8+ population in HD are similar, a significant increase was observed in CD8lo T cell frequency in COVID-19 patients. CD8lo T cell populations from HD as well as from SARS-CoV-2 infected patients exhibited lower frequencies of the effector cytokine-producing cells, TNF, IL-2, and IFN-γ, than CD8hi T cells. Interestingly, the frequency of CD8lo T cells increased with disease severity, suggesting that this parameter could be a potential marker for disease progression. Indeed, the CD8hi/CD8lo index helped to significantly improve the patient’s clinical stratification and disease outcome prediction. Our data support the addition of, at least, a CD8hi/CD8lo index into the panel of biomarkers commonly used in clinical labs, since its determination may be a useful tool with impact on the therapeutic management of the patients.

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Características clínicas y epidemiológicas de pacientes hospitalizados por infección por SARS-CoV-2 en dos hospitales en Córdoba

Cited by 7 publications

References 22 publications

Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities

Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities

Estimativa do excesso de mortalidade em hospital universitário do Paraná durante a pandemia de COVID-19

COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity

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