Características laboratoriais de um grupo de pacientes com artrite reumatoide inicial

Abstract

Introduction/Objective: To characterize a population of patients with early rheumatoid arthritis (RA) according to laboratory aspects, comparing it with other similar cohorts. Methods: Data presented are part of a prospective incident cohort study that evaluated 65 patients with early RA, followed for 36 months from the diagnosis at Early Rheumatoid Arthritis Clinic of Hospital Universitário de Brasília (HUB). We recorded demographics, clinical, and laboratory data relevant to the cohort initial assessment, including red blood cells, evidence of inflammatory activity, and presence of autoantibodies (rheumatoid factor (RF)), cyclic citrullinated peptide antibodies (anti-CCP), and antivimentin citrullinated (anti-Sa). Results: There was a preponderance of female (86%) with mean age of 45.6 years. Twelve patients (18.46%) had laboratory diagnosis of anemia (hemoglobin < 12 g / dL). Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were above the reference value for 51 (78.46%) and 46 (70.76%) patients, respectively. Thirty-two patients (49.23%) were positive for at least one of the RF isotypes, and 28 patients (43.07%) were positive for IgA RF, 19 (29.23%) for IgG, and 32 ( 49.23%) for IgM RF, respectively; 34 patients (52.30%) were positive for at least one of the techniques used in investigation of anti-CCP (CCP2, or CCP3, or CCP3.1), while 9 (13,85%) were positive for anti-Sa. Conclusions:The laboratory characteristics of patients enrolled in this Brazilian cohort are similar in many respects to those of North-American, European, and Latin-American cohorts previously published.

Human IgG detection in serum on polymer based Mach-Zehnder interferometric biosensors

“…Table gives a few examples of required detection limits for medical applications such as the confirmation of the hepatitis B (required lower limit 2.4 nM) or hepatitis A vaccination status (lower limit 19.1 nM) . For the analysis of samples from rheumatoid arthritis patients (∼17 000 nM), sample dilutions by a factor of at least 100 will be necessary in order to be in the linear range of the current bioassays .…”

Infecções graves em pacientes com artrite reumatoide expostos aos medicamentos biológicos: relevância e modificações da taxa com o tempo – dados de registros da américa do sul

“…Médias e grandes articulações também podem apresentar-se inflamadas, porém esse envolvimento é menos frequente (BRASINGTON JR., 2015). Cerca de 80% dos pacientes apresentam fator reumatoide positivo (FR), mas é importante lembrar que, quando avaliamos pacientes com artrite inicial, o percentual encontrado é menor; isso mostra que esse exame ajuda a estabelecer o diagnóstico, mas não é fundamental para tal (BRASINGTON JR., 2015;MOUTERDE et al, 2014;MOTA et al, 2010;NELL-DUXNEUNER et al, 2010). Outro autoanticorpo encontrado nos pacientes com AR é o anticorpo antipeptídeo C citrulinado (anti-CCP), que costuma surgir antes do FR no curso da patologia e apresenta maior especificidade (BRASINGTON JR., 2015;MOUTERDE et al, 2014;NISHIMURA et al, 2007).…”

Pterodon pubescens Benth.

“…A artrite reumatoide (AR) é uma doença autoimune inflamatória sistêmica caracterizada pelo comprometimento da membrana sinovial das articulações periféricas. A prevalência da AR é estimada em 0,5 % -1,0 % da população, com predomínio em mulheres e maior incidência na faixa etária de 30-50 anos (Mota et al, 2010;Usnayo et al, 2011;Barnabe et al, 2012).…”