Caractéristiques du syndrome d’apnées du sommeil dans une cohorte de patients acromégales

Computed tomography airway lumen volumetry in patients with acromegaly: Association with growth hormone levels and lung function

“…Acromegaly is a rare endocrine condition that results from excessive production of growth hormone (GH) and insulin‐like growth factor I (IGF‐I). In 98% of cases, the condition is caused by GH‐secreting pituitary adenoma (somatotropinoma) . In patients with acromegaly, the specific mortality due to pulmonary causes is 2–3 times higher than that observed in normal subjects .…”

“…In 98% of cases, the condition is caused by GH‐secreting pituitary adenoma (somatotropinoma) . In patients with acromegaly, the specific mortality due to pulmonary causes is 2–3 times higher than that observed in normal subjects . Many anatomical and functional abnormalities of the respiratory system have been described in these patients .…”

“…Many anatomical and functional abnormalities of the respiratory system have been described in these patients . Anatomical distortions of the thorax geometry and changes in soft tissues, joints, the respiratory mucosa, lung volume and respiratory muscle activity have been reported in previous studies . With regard to functional abnormalities related to the respiratory tract in patients with acromegaly, few studies have specifically approached this topic, particularly in the trachea and large airways, which have been considered a ‘forgotten zone’, with potential for obstructive events …”