Caractéristiques épidémiologiques des patients atteints d’hémopathies malignes à Abidjan au cours de la décennie 1995–2004

Sawadogo, Duni; Yapo, Adou; Sangaré, Mamadou; Tolo, A.; Yayo-Ayé, M.

doi:10.1007/s12558-008-0002-z

Cited by 12 publications

(21 citation statements)

References 2 publications

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“…Like others African authors,1,14,15 we found a slight male predominance (table 1). Patients were young adults with an average age of 33 ± 21.7 years (table 1).…”

Section: Discussionsupporting

confidence: 88%

“…We did not diagnose any erythrocytic leukemia or megakaryocytic leukemia. They are uncommon in the African series1,11,14,15 (table 1). With cytology and cytochemistry 17.3% of AL could not be classified.…”

Section: Discussionmentioning

confidence: 99%

“…In Côte d’Ivoire, cancers in general and hematological malignancies in particular are booming due to urbanization and HIV-AIDS 1–3. According to Tanon,3 non-Hodgkin lymphomas were associated with HIV infection but not with leukemia 3.…”

Section: Introductionmentioning

confidence: 99%

“…According to Tanon,3 non-Hodgkin lymphomas were associated with HIV infection but not with leukemia 3. Acute leukemia (AL) accounted for 12.5% of hematological malignancies and were more related with pollution and environment 1,2…”

Section: Introductionmentioning

confidence: 99%

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Interest in Determining the Cd34+ Cd38- Phenotype in the Diagnosis and Prognosis of Acute Leukemia in Abidjan – Côte D’ivoire

Sawadogo¹,

Tolo

Kassi

et al. 2013

Mediterr J Hematol Infect Dis

263

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BackgroundIn Côte d’Ivoire, acute leukemias account for 12.5% of hematological malignancies. Acute leukemias are due to an anomaly of the stem cell characterized among other things by the expression of CD34+ CD38− surface markers. This CD34+ CD38− phenotype as well as other factors such as tumor syndrome, high leukocytosis and blasts are considered as important factors of poor prognosis. We therefore proposed to investigate the prognostic value of the expression of CD34+ CD38− markers in acute leukemias in Abidjan.MethodsWe selected 23 patients aged 33 years on whom we performed Complete Blood Count, bone marrow aspiration and immunophenotyping. To search for myeloperoxydase, smears of blood or bone marrow were stained with benzidine and revealed by the use of Hydrogen peroxide. Acute leukemias were then identified and distributed using the score proposed by the European Group for the Immunological characterization of Leukemias. The definitive diagnosis was made by combining morphological characters that serve as the basis for the French-American-British classification as well as cytochemical and immunophenotypic characters.ResultsAccording to the cytological and immunophenotypic classifications, the acute lymphoid leukemia 2 and B IV predominated. 52.2% (12/33) of patients were CD34+ CD38−. This phenotype was found in almost all cytological immunophenotypic types. The medullary invasion by blasts (reflection of the tumor mass) of the total sample of CD34+, CD34+ CD38− patients and those not expressing CD34+ was respectively 79.4%, 81.25%, 83.3% and 74.8%.ConclusionThere was therefore no correlation between medullary blasts and the expression of CD34+ CD38−. To the factors we selected it would have been necessary to associate the study of cytogenetic and molecular anomalies to better understand the role of CD34+ CD38− phenotype, concerning prognosis.

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“…Like others African authors,1,14,15 we found a slight male predominance (table 1). Patients were young adults with an average age of 33 ± 21.7 years (table 1).…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interest in Determining the Cd34+ Cd38- Phenotype in the Diagnosis and Prognosis of Acute Leukemia in Abidjan – Côte D’ivoire

Sawadogo¹,

Tolo

Kassi

et al. 2013

Mediterr J Hematol Infect Dis

263

View full text Add to dashboard Cite

show abstract

“…En effet, à Abidjan, l'incidence hospitalière des hémopathies malignes n'a cessé de croître. Elle est passée de 43,2 (1972 à 1981) à 53,5 (1991 à 2003) et à 168,1 (1995 à 2004) [13].…”

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Traitement du cancer par thérapie cellulaire: cellules souches embryonnaires versus cellules souches adultes. Quels sont les aspects éthiques ?

Sawadogo

2010

J Afr Cancer

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Estimates of serious fungal infection burden in Côte d’Ivoire and country health profile

Koffi

Bonouman

Touré

et al. 2021

Journal of Medical Mycology

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Caractéristiques épidémiologiques des patients atteints d’hémopathies malignes à Abidjan au cours de la décennie 1995–2004

Cited by 12 publications

References 2 publications

Interest in Determining the Cd34+ Cd38- Phenotype in the Diagnosis and Prognosis of Acute Leukemia in Abidjan – Côte D’ivoire

Interest in Determining the Cd34+ Cd38- Phenotype in the Diagnosis and Prognosis of Acute Leukemia in Abidjan – Côte D’ivoire

Traitement du cancer par thérapie cellulaire: cellules souches embryonnaires versus cellules souches adultes. Quels sont les aspects éthiques ?

Estimates of serious fungal infection burden in Côte d’Ivoire and country health profile

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