Caractéristiques épidémiologiques et histopathologiques de 1280 cancers du col utérin à Kinshasa

Mukuku²,

et al. 2022

Cancer Reports

Introduction: Breast cancer is the most frequent type of cancer in women and is characterized by late clinical signs in developing countries, including the Democratic Republic of the Congo. One of the main reasons of death from breast cancer is lack of awareness and screening, which has led to late diagnosis (at an advanced stage).This study aims to measure women's knowledge regarding breast cancer in Kinshasa, in the Democratic Republic of the Congo. Materials and Methods:A cross-sectional study of 489 women aged 20-65 years was conducted. Data was collected using a predesigned, tested, self-administered questionnaire. The questionnaire included specific sections to test the participants' knowledge related to breast cancer and its screening, and practices related to breast self-examination (BSE). Bivariate and multivariate analyzes were used.Results: Our results indicated that 22.09% of the participants had good breast cancer knowledge and 77.91% had poor breast cancer knowledge. Overall, 322 (65.85%) participants recognized that BSE is a valuable method for early screening of BSE. In total, 136 (27.81%) respondents had learned to do the BSE and 216 (44.17%) had reported doing it. Two hundred and ninety-two (59.71%) respondents mentioned that any woman was at risk for breast cancer and 357 (71.78%) mentioned that it was possible to prevent breast cancer. Determinants of an adequate level of knowledge were higher/university educational level (adjusted odds ratio = 2.70; 95% confidence interval: 1.27-5.73; p = .010) and having previously been screened for breast cancer (adjusted odds ratio = 2.31; 95% confidence interval: 1.40-3.83; p = .001). Conclusion:The majority (77.91%) of women have demonstrated poor knowledge of signs/symptoms, risk factors, and screening methods of breast cancer. Additional efforts should be made through women's healthcare workers to raise knowledge of breast cancer screening.

Section: Methodsmentioning

confidence: 99%

Knowledge regarding breast cancer among Congolese women in Kinshasa, Democratic Republic of the Congo

Mukuku²,

et al. 2022

Cancer Reports

“…It includes different histological subtypes: squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma [1]. In cervical cancer, the most common type is squamous cell carcinoma (73,2%), cervical adenocarcinoma secondly (18,4%), and then cervical adenosquamous carcinoma (8,4%) [2]. For decades, the incidence rate of cervical squamous cell carcinoma has been declining continuously.…”

Section: Introductionmentioning

confidence: 99%

Case report: Response with chemotherapy and Olaparib in a patient with advanced cervical adenocarcinoma

Zhuang

Qin

Kou

et al. 2023

Preprint

Background: Cervical adenocarcinomas are a heterogeneous group of tumors, accounting for approximately 20% of all cervical cancers. Many clinical data suggest that the activity of PARPi inhibitors may not be limited to BRCA mutated tumours and may involve the homologous recombination pathway. At present, there are few data available on the activity of PARPi in endometrial and cervical cancers. And poly-(ADP)-ribose polymerase inhibitors (PARPi) are changing clinical practice in the BRCA mutant patients with cervical cancer. Case Description: Here, we report the case of a 66-year-old female patient admitted to the hospital due to abnormal vaginal bleeding. She was diagnosed with advanced cervical adenocarcinomas, and received chemotherapy followed by Paclitaxe and Cisplatin in the first-line. However, after one cycle of treatment, the patient's disease progressed. To identify more opportunities for treatment, the biopsy tissue was genetic tested and found BRCA1 exon 23 mutation and PD-L1 positive score, which motivated chemotherapy combined with immune checkpoint inhibitors, and the tumor size decreased. However, because of the side effects of from long-term chemotherapy, the patient chosen Olaparib treatment in the later stage. The patient benefited long-term disease control for about 24 months. Conclusions: This case might support the strategy that PARPi could be an alternative treatment for cervical adenocarcinoma patients with BRCA1 mutation in the future.

Immunohistochemical Features of Breast Cancer Seen in Women in Kinshasa, Democratic Republic of the Congo: A Six-Year Retrospective Study

Batalansi

International Journal of Breast Cancer

et al. 2022

Introduction. The molecular classification of breast cancer (BC) based on gene expression and then protein profile has made it possible to distinguish different molecular subtypes. The objective of this study was to describe immunohistochemical features of BC infiltrating women at the Nganda Hospital Center in Kinshasa, Democratic Republic of the Congo (DRC). Methods. A retrospective study from 2014 to 2019 involved 190 patients with invasive BC who were enrolled at the Nganda Hospital Center. The tumors were analyzed histologically and classified after an immunohistochemical study into subtypes: luminal A, luminal B, HER2-overexpressed, and triple-negative. A chi-square test was performed to assess the relationship between age, histological grade, and these subtypes. Results. The luminal A subtype (44.74%) was the most common, followed by luminal B (40.53%), triple-negative (10.53%), and HER2-overexpressed (4.20%). The mean age of the patients at diagnosis was 48.27 years. Of all cases, 94.21% were ductal, 2.63% were mucinous, and 2.11% were lobular. They were classified as grade I in 68.82% of the cases, grade II in 28.42% of the cases, and grade III in 3.16% of the cases. There was a significant association between histological grade and breast cancer subtypes ( p < 0.0001 ), but no correlation was found with age ( p = 0.467 ). Conclusion. In our BC patients, the luminal A was predominant, while HER2-overexpressed was the least found. A strong association was noted between histological grade and molecular subtypes. These results should allow for important clinical and policy implications for BC control in the DRC.