Carambola-like Bi<sub>2</sub>Te<sub>3</sub> superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the second near-infrared biowindow

Zhao, Ying; Liu, Yang; Wang, Qishun; Liu, Jianhua; Zhang, Songtao; Zhang, Tianqi; Wang, Daguang; Wang, Yinghui; Jin, Longhai; Zhang, Hongjie

doi:10.1039/d1tb00694k

Cited by 13 publications

(5 citation statements)

References 37 publications

(35 reference statements)

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“…The photothermal conversion efficiency value (η) of Cy5-TPA was further calculated to be 45.6% (Figure h), much higher than that of Cy5 (6.55%) and Cy5-Br (10.4%) (Figures S23–S25) and among the top of these most widely used photothermal agents with similar absorption bands (Table S1). − Collectively, we infer that the propeller geometry of the TPA moiety is the key reason for the excellent photothermal effect of Cy5-TPA . TPA renders Cy5-TPA the active intramolecular motions, which promotes excited energy dissipation through nonradiative decay, thus improving the photothermal conversion capacity.…”

Section: Resultsmentioning

confidence: 86%

Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy

Yu,

Wang,

Zhuang

et al. 2024

ACS Nano

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Photodynamic therapy (PDT) and photothermal therapy (PTT) possess different merits in cancer phototherapy, but the tumor microenvironment becomes unfavorable during the phototheranostic progress. Herein, we report a self-adaptive cyanine derivative Cy5-TPA with the PDT-dominated state to PTT-dominated state autoswitch feature for enhanced photoimmunotherapy. The incorporation of rotatable triphenylamine (TPA) moiety renders Cy5-TPA with the temperature or intramolecular-motion regulated photoactivities, which shows preferable reactive oxygen species (ROS) generation at lower temperature while stronger photothermal conversion at higher ones. Such a promising feature permits the in situ switch from PDT-dominated state to PTT-dominated state along with intratumoral temperature increase during laser irradiation, which also works in line with the concurrently reduced intratumoral oxygen level, exhibiting a self-adaptive phototherapeutic behavior to maximize the phototherapeutic antitumor outcome. Most importantly, the self-adaptive PDT-dominated state to PTT-dominated state switch also facilitates the sequential generation and release of damage-associated molecular patterns during immunogenic cell death (ICD). Hence, Cy5-TPA demonstrates excellent photoimmunotherapy performance in ICD induction, dendritic cell maturation, and T cell activation for tumor eradication and metastasis inhibition.

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Section: Resultsmentioning

confidence: 86%

Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy

Yu,

Wang,

Zhuang

et al. 2024

ACS Nano

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“…Most of the PTAs introduced before only absorbed the first near-infrared (NIR-I, 750–1000 nm) light with low maximum permissible exposure (MPE, 0.33 W cm −2 for 808 nm) and weak tissue penetration ability, which is unfavorable for practical clinical applications [ 70 , 71 ]. In contrast, the second near-infrared (NIR-II, 1000–1700 nm) light penetrates deeper into biological tissue and shows larger MPE (1.0 W cm −2 for 1064 nm), which is more suitable for PTT [ 15 , 72 ].…”

Section: Bioceramic Scaffoldsmentioning

confidence: 99%

Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration

et al. 2023

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Despite the significant improvement in the survival rate of cancer patients, the total cure of bone cancer is still a knotty clinical challenge. Traditional surgical resectionof bone tumors is less than satisfactory, which inevitably results in bone defects and the inevitable residual tumor cells. For the purpose of realizing minimal invasiveness and local curative effects, photothermal therapy (PTT) under the irradiation of near-infrared light has made extensive progress in ablating tumors, and various photothermal therapeutic agents (PTAs) for the treatment of bone tumors have thus been reported in the past few years, has and have tended to focus on osteogenic bio-scaffolds modified with PTAs in order to break through the limitation that PTT lacks, osteogenic capacity. These so-called bifunctional scaffolds simultaneously ablate bone tumors and generate new tissues at the bone defects. This review summarizes the recent application progress of various bifunctional scaffolds and puts forward some practical constraints and future perspectives on bifunctional scaffolds for tumor therapy and bone regeneration: two hawks with one arrow.

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“…To help minimize the toxicity, the above-mentioned studies have incorporated polymers (such as PEG, PVP and PTMP-PMMA), BSA and RBCs to improve the physiological stability, biocompatibility and blood-circulation time, but the lack of targeting capabilities still results in unsatisfactory tumor accumulation. Therefore, cancer-specific units, such as folic acid (FA), hyaluronic acid (HA) and arginine-glycine-aspartic acid (RGD) peptide, should be functionalized on the next-generation Fe-based nanoagents [ 77 , 78 , 79 ]. Even though the development of biodegradable and clearable Fe-based nanoagents is encouraging, additional research is still needed to fully investigate the short- and long-term safety of these promising nanoagents.…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

et al. 2022

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Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability to stop growth and metastasis or prevent relapse. Thus, synergistic strategies that combine different therapeutic modalities to improve performance have become the new research trend. In this regard, the integration of photothermal therapy (PTT) with chemodynamic therapy (CDT), especially PTT/CDT in the second near-infrared (NIR-II) biowindow, has been demonstrated to be a highly efficient and relatively safe concept. With the rapid development of nanotechnology, nanoparticles can be designed from specific elements, such as Fe, that are equipped with both PTT and CDT therapeutic functions. In this review, we provide an update on the recent advances in Fe-based nanoplatforms for combined PTT/CDT. The perspectives on further improvement of the curative efficiency are described, highlighting the important scientific obstacles that require resolution in order to reach greater heights of clinical success. We hope this review will inspire the interest of researchers in developing novel Fe-based nanomedicines for multifunctional theranostics.

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Carambola-like Bi₂Te₃ superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the second near-infrared biowindow

Abstract: Photothermal therapy (PTT) stimulated by the lights in the second near-infrared (NIR-II) biowindow shows great superiorities in penetration ability of tissue and maximum permissible exposure (MPE). Exploring new photothermal agents...

Cited by 13 publications

References 37 publications

Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy

Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy

Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

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Carambola-like Bi2Te3 superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the second near-infrared biowindow

Abstract: Photothermal therapy (PTT) stimulated by the lights in the second near-infrared (NIR-II) biowindow shows great superiorities in penetration ability of tissue and maximum permissible exposure (MPE). Exploring new photothermal agents...

Cited by 13 publications

References 37 publications

Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy

Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy

Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

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Carambola-like Bi₂Te₃ superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the second near-infrared biowindow