Carbamazepine effects on pain management and serum IL-6, IL-10 evaluation in addicted patients undergoing surgery

Salimi, Alireza; Sabetkasaei, Masoumeh; Raisi, H; Labibi, Farzaneh; Ameli, Haleh; Khazaei-Poul, Yalda; Zarei, Malek; Mottaghi, Kamran; Safari, Fatemeh; Nazem-Bokaei, Ali; Mohajerani, Seyed-Amir; Moini-Zanjani, Taraneh

doi:10.1016/j.ejphar.2017.07.011

Cited by 9 publications

(8 citation statements)

References 43 publications

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“…Perioperative pain may play an important role in modulating cytokines ( 25 ). For example, postoperative analgesic modalities after laparoscopic colorectal surgery attenuated the cytokine response as IL-6 expression ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

et al. 2021

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Background: Tissue damage caused by major surgery, such as cesarean section, may lead to a poor host immune response and excessive release of cytokines. These responses may increase the risk of infection, cause postoperative pain, and exert damaging effects on various body organs. Objectives: Anesthesia methods may affect cytokine production after surgery. This study aimed to compare the serum levels of cytokines in general and spinal anesthesia among women undergoing cesarean section. Methods: Thirty parturients (ASA class I and II) undergoing cesarean section were randomly assigned into two equal groups of spinal anesthesia and general anesthesia. Blood samples were taken for measuring the levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) before induction of anesthesia and 30 minutes after entering the recovery room. Results: In the general anesthesia group, the postoperative serum levels of IL-6 and TNF-α were significantly higher than the corresponding preoperative levels. Significant differences were found between the two groups in the preoperative and postoperative levels of TNF-α. Changes in the IL-6 and TNF-α concentrations were significantly higher in the general anesthesia group as compared to the spinal anesthesia group. However, there was no significant difference in the IL-6:IL-10 and TNF-α: IL-10 ratios between the two groups. Conclusions: General anesthesia, as compared to spinal anesthesia, significantly increased the IL-6 and TNF-α levels after cesarean section. Therefore, the spinal anesthesia technique may be a better option for patients undergoing cesarean section.

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Section: Discussionmentioning

confidence: 99%

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

et al. 2021

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“…A randomised, double-blind experimental study conducted by Salimi et al sought to evaluate the use of pre-operative CBZ as a mitigating agent on post-operative analgesia in patients who had an addiction to opioids. 15 The primary outcome was to study the effect of pre-emptive CBZ use on pain behaviour, as well as to measure serum interleukin (IL) IL-6 and IL-10 levels. These inflammatory cytokines are routinely elevated in CBZ effectively decreased pain and modulated pain behaviour in patients with an addiction to opioids.…”

Section: Resultsmentioning

confidence: 99%

“…Though significant heterogeneity exists with regard to dosing regimens, patient populations, and markers of effectiveness, both CBZ and OXC are likely underutilised for this indication. 12,15 One method by which adjunctive analgesics are evaluated for their efficacy is the reduction in concomitant opioid doses. In a retrospective cohort analysis of 309 patients, Yang et al attempted to discover whether or not surgical intervention for trigeminal neuralgia led to less opioid usage.…”

Section: Discussionmentioning

confidence: 99%

“…While the findings of this report do little to supersede the low quality of evidence identified in a previously‐published Cochrane review, they do support the need for continued future investigation. Though significant heterogeneity exists with regard to dosing regimens, patient populations, and markers of effectiveness, both CBZ and OXC are likely underutilised for this indication 12,15 …”

Section: Discussionmentioning

confidence: 99%

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Carbamazepine, oxcarbazepine, and lacosamide as adjunctive analgesics: a review of the literature

Reinert

Nuon

Veronin

2021

Pharmacy Practice and Res

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The pursuit of ideal multi-modal analgesic strategies remains ongoing, though the use of select antiepileptic drugs as adjunctive analgesics to opioids has been previously studied and postulated to have varying degrees of success. The objective of this review was to determine the efficacy and safety of select antiepileptic drugs as adjunctive analgesics in an update to a previously published Cochrane review on the subject in 2013. A comprehensive literature review was conducted using PubMed, MEDLINE, Scopus, and Web of Science between January 2013-August 2020 using: "carbamazepine" OR "oxcarbazepine" OR "lacosamide" AND "analgesia". The use of one of the study drugs as an adjunctive analgesic to opioids was included. Thirty-five articles were identified through database inquiries, though only two reports met inclusion criteria, with one focusing on carbamazepine and one focusing on oxcarbazepine. No articles detailing lacosamide in accordance with the scope of this review were identified. Both carbamazepine and oxcarbazepine demonstrated safety and efficacy as adjunctive analgesics across numerous indications, including postoperative neuropathies and neuropathies associated with spinal cord injuries. While the search for a universal or definitive multi-modal pain management regimen remains elusive, carbamazepine and oxcarbazepine have demonstrated clinical utility in pain syndromes beyond their historic relegation to trigeminal neuralgia. Limited evaluation and data has been derived regarding the use of carbamazepine, oxcarbazepine, and lacosamide since the previous Cochrane review in 2013. The results of this review solidify the need for continued future investigation. Additional data is necessary to define the role of lacosamide for this indication.

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“…Relevantly, many drugs routinely used for chronic pain management have been shown to decrease IL-6 levels, especially lidocaine IV, cannabinoids, and (indirectly) anticonvulsants. [17][18][19][20][21][22][23][24][25][26] According to the 2017 National Health Survey in Spain, [27] low back pain and osteoarthritis are the second and third most common health problems in Spain, affecting 18.5% and 17.5%, respectively, of the population. Given this high prevalence, the potential effects of drugs used to treat these and other comorbidities in patients with COVID-19 may be particularly relevant for individuals receiving medical treatment for chronic pain, which include NSAIDs, paracetamol, metamizole, corticosteroids, opioids, anticonvulsants, antidepressants, lidocaine, ketamine, cannabinoids, and naltrexone.…”

Section: Introductionmentioning

confidence: 99%

Association between chronic pain medications and the severity and mortality of COVID-19

et al. 2021

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Carbamazepine effects on pain management and serum IL-6, IL-10 evaluation in addicted patients undergoing surgery

Cited by 9 publications

References 43 publications

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial

Carbamazepine, oxcarbazepine, and lacosamide as adjunctive analgesics: a review of the literature

Association between chronic pain medications and the severity and mortality of COVID-19

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