Carbamazepine Induced Red Blood Cell Aplasia A case Report

Özkaya, Halit; Aydemir, Gokhan; Akcan, Abdullah Barış; Kul, Mustafa; Karademır, Ferhan; Aydınöz, Seçil; Süleymanoğlu, Selami

doi:10.5505/tjh.2012.52296

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…It has been stated that the hematological side effects of AEDs may range from thrombocytopenia to neutropenia, anemia, red cell aplasia, and bone marrow failure. [5,6] In some studies, it has been reported that old-generation AEDs such as CBZ, PHT, phenobarbital, VPA induce frequent hematological changes when compared with new-generation AEDs (such as PGB, GBP, LEV, LTG, OXC, TPM, ZA), comparable to our results. [5] The causes of hematological side effects of AEDs have not been fully understood, yet.…”

Section: Discussionsupporting

confidence: 90%

Eski ve Yeni Kuşak Antiepileptik İlaçların Hemogram Parametrelerine Etkileri Farklı Mı?

KÖMÜRCÜ

Sarıçam

Anlar

2022

Journal of Contemporary Medicine

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Introduction: There are different comments related to hematological side effects caused by antiepileptic drugs (AEDs). In our study, we investigated the effects of AEDs on hemogram parameters. Material and Method: Hemogram values of 293 patients including 156 women, who used AEDs for at least six months, were compared with the values of 36 healthy control participants group who did not. In addition, the hemogram values of the patients using oldgeneration AEDs such as phenytoin (PHT), carbamazepine (CBZ), valproic acid were compared with those using new-generation AEDs as levetiracetam, oxcarbazepine, pregabalin (PGB), gabapentin and two AEDs in combination. Results: Comparison of the patients using AEDs with the control group revealed that white blood cell (WBC) values of only PHT users were lower than the control group (p=0.045). Red cell distribution width (RDW) values were found to be higher in healthy controls than those using AEDs (p<0.001). When the groups using AEDs were compared among themselves, it was found that the WBC values of the users of old-generation AEDs as PHT and CBZ were significantly lower than those using PGB (p=0.006; P=0.005, respectively). Conclusions: As hematological side effects, AEDs may decrease WBC counts. The WBC decreasing effects of PHT and CBZ, which are older generation antiepileptics, are more pronounced than pregabalin, which is a new-generation AED. The effects of AEDs on hemogram parameters of the patients should be taken into consideration while choosing appropriate AEDs and also while following the patient.

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Section: Discussionsupporting

confidence: 90%

Eski ve Yeni Kuşak Antiepileptik İlaçların Hemogram Parametrelerine Etkileri Farklı Mı?

KÖMÜRCÜ

Sarıçam

Anlar

2022

Journal of Contemporary Medicine

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“…Antiepileptics such as diphenylhydantoin, sodium valproate, and carbamazepine were previously reported to be associated with PRCA. [3][4][5] Drugs can be responsible for various red blood cell-related syndromes, including hemolytic anemia, methemoglobinemia, PRCA, sideroblastic anemia, megaloblastic anemia, and polycythemia.…”

Section: Discussionmentioning

confidence: 99%

“…It resolved following discontinuation of carbamazepine. 4 Few more cases of carbamazepineinduced PRCA were reported previously in the literature. [6][7][8][9] We present this case to make the readers aware of an extremely rare complication related to carbamazepine, which is reversible with discontinuation of the drug.…”

Section: Discussionmentioning

confidence: 99%

Carbamazepine-Induced Pure Red Cell Aplasia

Mansoor

Priya²

2018

International Journal of Epilepsy

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).Antiepileptic therapy is associated with various hematologic disorders. Pure red cell aplasia (PRCA) is a rare disease that may be congenital or acquired. Severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow should raise the suspicion of PRCA. A 32-year-old unmarried woman was admitted with fatigue for 4 months. She had been on carbamazepine therapy for 4 years (200 mg twice daily) for seizure disorder. On evaluation, she was diagnosed to have PRCA secondary to carbamazepine. We describe a patient with carbamazepine-induced PRCA that improved after discontinuation of the drug. AbstractKeywords ► antiepileptic therapy ► carbamazepine ► pure red cell aplasia Int

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“…In contrast to these findings some scientists opined that AEDs do not have any effect on the biochemical and hematological parameters of epileptic patients [26]. Some of the AEDs implicated in pure red blood cell (RBC) aplasia include diphenylhydantoin, sodium valproate and CBZ [27]. Aliyu et al [23] reported a decrease in RBC count and neutrophilia following the administration of CBZ and PHT; a non-significant decrease in RBC counts with co-administration of CBZ and PHT and lymphocytosis with CBZ administration.…”

Section: Side Effectsmentioning

confidence: 99%