Carbamazepine: Out with the old, in with the new?

Lawthom, Charlotte

doi:10.1016/j.seizure.2020.10.026

Cited by 4 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VPA for example, induce ROS formation and apoptosis and inhibit histone deacetylase (HDAC) (Tomson et al, 2016). CBZ, is a potent enzyme inducer acting through 1A2, 2B6, 2C9, 2C19, and 3A4/5 CYP targets acting directly on endogenous metabolic pathways and also has been documented that enhances adipogenesis inhibiting Wnt/β-Catenin expression (Brodie et al, 2013;Lawthom, 2020). PHT, inhibit non-NMDA glutamate receptors with greater affinity to the Ca 2+ -impermeable AMPA receptors (Dron et al, 2021) and additionally inhibit the cardiac calcium release channels ryanodine receptor 2 (RyR2; Ashna et al, 2020).…”

Section: Sodium Channelsmentioning

confidence: 99%

Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets

Castro

Pinto-Borguero²,

Yévenes³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

The main strategy for the treatment of epilepsy is the use of pharmacological agents known as antiseizure medication (ASM). These drugs control the seizure onset and improves the life expectancy and quality of life of patients. Several ASMs are contraindicated during pregnancy, due to a potential teratogen risk. For this reason, the pharmacological treatments of the pregnant Women with Epilepsy (WWE) need comprehensive analyses to reduce fetal risk during the first trimester of pregnancy. The mechanisms by which ASM are teratogens are still under study and scientists in the field, propose different hypotheses. One of them, which will be addressed in this review, corresponds to the potential alteration of ASM on ion channels and proteins involved in relevant signaling and cellular responses (i.e., migration, differentiation) during embryonic development. The actual information related to the action of ASM and its possible targets it is poorly understood. In this review, we will focus on describing the eventual presence of some ion channels and synaptic proteins of the neurotransmitter signaling pathways present during early neural development, which could potentially interacting as targets of ASM. This information leads to elucidate whether these drugs would have the ability to affect critical signaling during periods of neural development that in turn could explain the fetal malformations observed by the use of ASM during pregnancy.

show abstract

Section: Sodium Channelsmentioning

confidence: 99%

Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets

Castro

Pinto-Borguero²,

Yévenes³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Food for thought: Opinions on the past, present and future of carbamazepine

Reuber

2020

Seizure

View full text Add to dashboard Cite

Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms

Lou

Cui

2022

CMC

View full text Add to dashboard Cite

: Epilepsy is a chronic brain disorder caused by abnormal firing of neurons. Up to now, using antiepileptic drugs is the main method of epilepsy treatment. The development of antiepileptic drugs lasted for centuries. In general, most agents entering clinical practice act on the balance mechanisms of brain “excitability-inhibition”. More specifically, they target voltage-gated ion channels, GABAergic transmission and glutamatergic transmission. In recent years, some novel drugs representing new mechanisms of action have been discovered. Although there are about 30 available drugs in the market, it is still in urgent need of discovering more effective and safer drugs. The development of new antiepileptic drugs is into a new era: from serendipitous discovery to evolutionary mechanism-based design. This article presents an overview of drug treatment of epilepsy, including a series of traditional and novel drugs.

show abstract

Carbamazepine: Out with the old, in with the new?

Cited by 4 publications

References 45 publications

Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets

Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets

Food for thought: Opinions on the past, present and future of carbamazepine

Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms

Contact Info

Product

Resources

About